Article
Oncology
Xia Chen, Qianwen Zheng, Li Ji, Yanyan Zhuang, Hao Yu, Xinmeng Cheng, Yun Han, Jinxing Lv, Bo Zheng, Yanli Zheng, Jun Yu
Summary: This study identified molecular signaling pathways related to missed abortion (MA) using a quantitative proteomics approach. They found that COX6C played a critical role in MA and its down-regulated expression may contribute to the pathophysiology of MA. The study helps to understand the pathophysiological mechanisms of MA.
EXPERIMENTAL CELL RESEARCH
(2022)
Article
Immunology
Muqiu Zhang, Dong Cui, Huixia Yang
Summary: The study found increased distribution of M2 macrophages in the chorionic villi of pregnant women with uncontrolled T2DM, while the subsets of M2 macrophages in the placental decidua were similar between uncontrolled T2DM pregnant women and normal groups.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Nadine Abu-Ghazaleh, Shaun Brennecke, Padma Murthi, Vijaya Karanam
Summary: Recurrent miscarriage (RM) refers to the occurrence of two or more consecutive miscarriages before 20 weeks' gestation. Vascular endothelial growth factors (VEGFs) are found to be lower in the endometrium of RM cases compared to controls. However, there are inconsistencies in the findings regarding VEGFs levels in decidua, fetoplacental tissues, and serum. Future studies should aim to use consistent definitions, sample collection methods, and laboratory analyses to clarify the association between VEGF and RM.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Rong Ma, Ni Jin, Hui Lei, Jie Dong, Yujing Xiong, Chenxi Qian, Shuqiang Chen, Xiaohong Wang
Summary: Ovarian stimulation is associated with abnormal placentation and a decrease in uterine natural killer (uNK) cell density. In this study, two mouse models were constructed and the results showed that ovarian stimulation resulted in reduced uNK cell density, fetal weight reduction, abnormal placental morphology, and decreased placental vascular density. Aberrant estrogen signaling may contribute to the disorder of uNK cells caused by ovarian stimulation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Maria Teresa Bruno, Salvatore Caruso, Guido Scalia, Maria Costanzo, Salvatore Di Pasqua, Sara Boemi, Marco Marzio Panella, Marco Palumbo
Summary: This study conducted a prospective, controlled investigation to evaluate the potential association between HPV infection and miscarriage. The results showed that the presence of HPV alone is not enough to cause spontaneous abortion, but a high viral load in early pregnancy may increase the risk of negative outcomes.
Article
Cell Biology
Paz de la Torre, Miguel Fernandez-de la Torre, Ana I. Flores
Summary: The study investigates the effects of MPA on decidual stromal cells, showing that MPA leads to decreased proliferation and viability of the cells. Molecular pathways impacted by MPA include reduction in pre-rRNA synthesis and disruption of the nucleolus, ultimately resulting in irreversible growth arrest of decidual cells.
JOURNAL OF BIOMEDICAL SCIENCE
(2021)
Article
Immunology
Shafat Ali, Sabhiya Majid, Md. Niamat Ali, Shahnaz Taing, Muneeb U. Rehman, Azher Arafah
Summary: Recurrent pregnancy loss (RPL) is a reproductive disease that involves two or more successive spontaneous abortions, with causes often related to dysfunction of endometrial cytokines and dysregulation of decidual cytokines. Cytokine modulatory therapies are considered promising for preventing RPL.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Immunology
Minyan Yang, Guanyou Huang, Hua Qian, Jun Wang, Shuyun Zhao, Shixiang Li, Yan Yuan
Summary: Research suggests that progesterone may be involved in the regulation of immune tolerance by negatively regulating the expression of IDO1 in the chorionic villi and decidua in early pregnancy.
Review
Endocrinology & Metabolism
Meenakshi Rana, Sidhant Jain, Pooja Choubey
Summary: Prolactin, besides its well-known functions in mammary gland development and lactation, participates in various physiological and biochemical processes across different species. It is not only secreted by lactotroph cells in the pituitary gland, but also by other cells and organs, exerting regulatory roles in the body. The placenta, one of the major organs secreting prolactin, has not been comprehensively studied in terms of its role in placental biology.
HORMONES-INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM
(2022)
Article
Immunology
Xian-Li Sun, Jing Zhao, Zhe Leng, Hui Lin, Yu Huang
Summary: The study found that serum CXCL12 levels were significantly lower in women who have miscarried compared to healthy early pregnancy women and normal non-pregnant women. Additionally, the expression levels of CXCR4 and CXCR7 proteins in decidua tissues were significantly lower in women who have miscarried compared to early pregnancy women.
IMMUNOLOGICAL INVESTIGATIONS
(2022)
Article
Immunology
Linlin Wang, Zhimin Deng, Jing Yang, Yulin Zhao, Linyan Zhou, Lianghui Diao, Longfei Li, Yanxiang Cheng
Summary: By combining bioinformatics and multi-omics analysis, differentially expressed genes (DE-genes) in villus and decidua of RM patients were identified, suggesting potential roles in cell growth, development, nutrient transport, immune response, extracellular matrix remodeling, and angiogenesis.
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2022)
Article
Nutrition & Dietetics
Perla Pizzi Argentato, Jorge Augusto Petroli Marchesi, Naiara Naiana Dejani, Patricia Yury Nakandakare, Laisla de Franca da Silva Teles, Livia Patricia Rodrigues Batista, Maria Paula Carvalho Leitao, Liania Alves Luzia, Ester Silveira Ramos, Patricia Helen Rondo
Summary: This study demonstrates for the first time the associations between imprinted genes variations at the maternal-fetal interface of the placenta and in cord blood with fetal body composition, supporting the involvement of epigenetic mechanisms in offspring growth and body composition.
FRONTIERS IN NUTRITION
(2023)
Review
Immunology
Nupur Mukherjee, Richa Sharma, Deepak Modi
Summary: Recurrent implantation failure (RIF) can be caused by uterine factors, male factors, or embryo factors. It is associated with disrupted endometrial receptivity, altered gene expression, immunologic disturbances, and epigenetic alterations. RIF is a heterogeneous condition with varied immune responses, and personalized therapies based on the patient's immune status are being tested.
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Wafaa S. Khalaf, Mohammad R. A. Mahmoud, Walid F. Elkhatib, Hany R. Hashem, Wafaa E. Soliman
Summary: The study found that DPNKT-like cell subset, IL-2, and IFN-gamma levels are significantly elevated in URM patients, and these parameters are also increased after pregnancy, serving as markers to predict the risk of miscarriage.
Article
Multidisciplinary Sciences
Rosete Maria Amorim Novais Nogueira Cardoso, Pedro Luis Novais Nogueira Cardoso, Ana Paula Azevedo, Jesus Siles Cadilla, Maria Graca Ribeiro Oliveira Rodrigues Amorim, Marcos Emanuel Rocha Gomes, Jorge Manuel Nunes Correia Pinto
Summary: Histopathological classification of first-trimester miscarriage is essential for determining the cause of pregnancy loss and guiding patient management. The study showed good concordance in pathological criteria, especially in categories related to embryo anomaly and gestational trophoblastic disease. A comprehensive histopathological classification may improve the accuracy of diagnosis for early spontaneous miscarriage.
Article
Endocrinology & Metabolism
D. Gentilini, M. Muzza, T. de Filippis, M. C. Vigone, G. Weber, L. Calzari, A. Cassio, M. Di Frenna, M. Bartolucci, E. S. Grassi, E. Carbone, A. Olivieri, L. Persani
Summary: Epigenetic modifications may play a role in the pathogenesis of congenital hypothyroidism (CH) and explain the discordance among monozygotic twins. The study found different methylation status of certain genes that may explain the CH discordance in a monozygotic twin couple. In addition, the median number of hypo-methylated Stochastic Epigenetic Mutations (SEMs) was significantly increased in CH cases compared to controls, suggesting the potential importance of epigenetic modifications in CH pathogenesis.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2023)
Article
Endocrinology & Metabolism
Claudio Giacomozzi, Ayelen Martin, Maria Celia Fernandez, Mariana Gutierrez, Maria Iascone, Horacio M. Domene, Fernando P. Dominici, Ignacio Bergada, Biagio Cangiano, Luca Persani, Patricia A. Pennisi
Summary: This study describes a 12.6-year-old girl with severe short stature and insulin resistance, but with normal hearing and neurological development. Whole exome sequencing revealed a novel IGF1 mutation, leading to low immunoreactive IGF1 levels in serum and significantly reduced bioactivity. The absence of significant hearing and neurodevelopmental involvement in this case is unusual and broadens the clinical spectrum of IGF1 mutations.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Review
Endocrinology & Metabolism
F. Moro, I Scavello, E. Maseroli, G. Rastrelli, C. Baima Poma, C. Bonin, F. Dassie, S. Federici, S. Fiengo, L. Guccione, M. Villani, A. Gambineri, R. Mioni, P. Moghetti, C. Moretti, L. Persani, G. Scambia, F. Giorgino, L. Vignozzi
Summary: The aim of this study was to standardize the definition of normal ovarian ultrasound parameters. Through summarizing and meta-analyzing the evidence from English articles, the study provides valuable information for the interpretation and diagnostic accuracy of ovarian ultrasound parameters in different physiological and pathological conditions.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2023)
Review
Endocrinology & Metabolism
Valeria Vezzoli, Faris Hrvat, Giovanni Goggi, Silvia Federici, Biagio Cangiano, Richard Quinton, Luca Persani, Marco Bonomi
Summary: Distinguishing between self-limited delayed puberty (SLDP) and congenital hypogonadotropic hypogonadism (CHH) can be challenging due to their similar clinical and biochemical characteristics. However, SLDP is typically transient while CHH is a lifelong condition. Differentiating between these two conditions is important because their natural history and long-term outcomes differ significantly. Genetic analysis using next-generation sequencing technology (NGS) has the potential to aid in the differential diagnosis between SLDP and CHH, providing an updated overview of their genetic architecture.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Medicine, Research & Experimental
Ludovica Cotellessa, Federica Marelli, Paolo Duminuco, Michela Adamo, Georgios E. . Papadakis, Lucia Bartoloni, Naoko Sato, Mariarosaria Lang-Muritano, Amineh Troendle, Waljit S. . Dhillo, Annamaria Morelli, Giulia Guarnieri, Nelly Pitteloud, Luca Persani, Marco Bonomi, Paolo Giacobini, Valeria Vezzoli
Summary: Fertility in vertebrate species is controlled by GnRH neurons, which arise outside the central nervous system and migrate into the forebrain during development. Genetic disorders associated with infertility, such as CHH and Kallmann syndrome, are characterized by defects in GnRH neuron migration. The study found that Jag1/Notch signaling is involved in the development of GnRH neurons, and JAG1 insufficiency may contribute to the pathogenesis of CHH in humans.
Article
Endocrinology & Metabolism
Giulia Rodari, Silvia Federici, Tommaso Todisco, Graziamaria Ubertini, Alessandro Cattoni, Marta Pagano, Federico Giacchetti, Eriselda Profka, Valeria Citterio, Dario Messetti, Valentina Collini, Davide Soranna, Erika Carbone, Maura Arosio, Giovanna Mantovani, Luca Persani, Marco Cappa, Marco Bonomi, Claudia Giavoli
Summary: This study aims to investigate the effects of pubertal induction on the reproductive system in hypogonadal girls. The findings suggest that an appropriate dosage of estrogen can promote breast and uterine development, while a proper dosage of progestin can limit further changes in uterine volume. Therefore, the selection of estrogen and progestin should be based on the patient's clinical response and appropriate dosage.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Simona Servida, Elena Panzeri, Laura Tomaino, Giovanni Marfia, Emanuele Garzia, Giuseppe Ciniglio Appiani, Gianluca Moroncini, Vito De Gennaro Colonna, Carlo La Vecchia, Luisella Vigna
Summary: This article discusses a case study of a helicopter pilot who experienced transient loss of consciousness during a low-altitude flight under curcumin and piperine treatment. Further investigation revealed the presence of previously asymptomatic insulinoma. The researchers hypothesize that the combined effects of curcumin and piperine may have caused severe hypoglycemia and subsequent loss of consciousness. Thus, more studies are needed to evaluate the safety of curcumin and piperine supplementation in individuals with impaired glucose metabolism and insulin secretion.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Ilaria Gentile, Valeria Vezzoli, Sara Martone, Maria Grazia Totaro, Marco Bonomi, Luca Persani, Federica Marelli
Summary: In this study, we investigated the effects of BaP on the HPG axis in zebrafish embryos. The results showed that BaP compromised the neuronal architecture of the GnRH3 network and upregulated antioxidant activity, oxidative DNA damage, and apoptosis pathways. These findings suggest that short-term exposure to BaP can adversely affect GnRH3 development in zebrafish embryos through a neurotoxic mechanism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Endocrinology & Metabolism
Federica Sileo, Joris A. J. Osinga, W. Edward Visser, Toyah A. Jansen, Wichor M. Bramer, Arash Derakhshan, Valeria Citterio, Henning Tiemeier, Luca Persani, Tim I. M. Korevaar
Summary: Postpartum depression (PPD) has a significant impact on maternal and offspring well-being. This study found no association between thyroid function/TPOAb positivity and PPD through a population-based prospective cohort study, systematic literature review, and meta-analysis.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Vittoria Favero, Cristina Eller-Vainicher, Valentina Morelli, Elisa Cairoli, Antonio Stefano Salcuni, Alfredo Scillitani, Sabrina Corbetta, Silvia Della Casa, Giovanna Muscogiuri, Luca Persani, Iacopo Chiodini
Summary: This study evaluated the prevalence and incidence of vertebral fractures in patients with adrenal incidentalomas and mild autonomous cortisol secretion. The results showed that patients with adrenal incidentalomas and mild autonomous cortisol secretion are at higher risk of vertebral fractures.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Review
Obstetrics & Gynecology
Federico Mecacci, Eleonora Romani, Sara Clemenza, Sara Zullino, Laura Avagliano, Felice Petraglia
Summary: Early onset fetal growth restriction (FGR) is often associated with poor neonatal outcomes. It is still unclear whether pregnancies complicated by early FGR plus hypertensive disorders of pregnancy (FGR-HDP) and those complicated by early onset FGR without HDP (normotensive-FGR (n-FGR)) show different prenatal and postnatal outcomes. Recent data suggest that the presence of preeclampsia may increase the risk of poor neonatal outcomes in pregnancy affected by early onset FGR-HDP compared to pregnancy affected by early onset n-FGR. This review aims to compare the clinical characteristics, perinatal outcomes, and potential long-term sequelae of early onset FGR-HDP and early onset n-FGR.
REPRODUCTIVE SCIENCES
(2023)
Article
Endocrinology & Metabolism
C. Cacciatore, B. Cangiano, E. Carbone, S. Spagnoli, M. P. Cid Ramirez, N. Polli, M. Bonomi, L. Persani
Summary: This study investigated factors influencing functional hypothalamic amenorrhea in patients with anorexia nervosa. The findings suggest that amenorrhea is not strictly correlated with body weight variations and has a multifactorial origin. Higher FT3 levels identify patients who continue having menses at extremely low BMI. Patients with persistent amenorrhea should consider using estroprogestins after significant weight recovery to prevent prolonged tissue hypoestrogenism.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2023)
Article
Pediatrics
Stefania Triunfo, Silvia Perossini, Esther Burdin, Elena Claudia De Angeli, Maria Francesi, Alessandra Garolfi, Jessica Moretti, Ilenia Paruscio, Miriam Tassielli, Marta Tremolada, Simona Gemelli, Deborah Pedrina, Anna Maria Marconi
Summary: This study investigated the impact of an additional lesson on vaccination during pregnancy in childbirth education classes. The results showed that pregnant women who attended the extra lesson on vaccination had lower anxiety levels and higher levels of well-being compared to those who did not receive the lesson. Additionally, pregnant women who did not receive education on vaccination reported higher levels of perceived stress.
Article
Oncology
Alessandra Dicitore, Germano Gaudenzi, Silvia Carra, Maria Celeste Cantone, Monica Oldani, Davide Saronni, Maria Orietta Borghi, Jacopo Grotteschi, Luca Persani, Giovanni Vitale
Summary: This study investigated the potential antitumor effects of axitinib on lung carcinoid cells using both in vitro and in vivo models. Axitinib demonstrated significant antitumor activity by reducing cell viability, inducing cell cycle arrest, and promoting cell death. It also had a notable impact on tumor-induced angiogenesis and invasiveness.
Article
Multidisciplinary Sciences
Erik Schoenmakers, Federica Marelli, Helle F. Jorgensen, W. Edward Visser, Carla Moran, Stefan Groeneweg, Carolina Avalos, Sean J. Jurgens, Nichola Figg, Alison Finigan, Neha Wali, Maura Agostini, Hannah Wardle-Jones, Greta Lyons, Rosemary Rusk, Deepa Gopalan, Philip Twiss, Jacob J. Visser, Martin Goddard, Samer A. M. Nashef, Robin Heijmen, Paul Clift, Sanjay Sinha, James P. Pirruccello, Patrick T. Ellinor, Elisabeth M. Busch-Nentwich, Ramiro Ramirez-Solis, Michael P. Murphy, Luca Persani, Martin Bennett, Krishna Chatterjee
Summary: This article reports a heritable deficiency disorder of selenoproteins caused by mutations in SECISBP2, which leads to oxidative stress-mediated aortic cell death, predisposing to thoracic aortic aneurysm formation.
NATURE COMMUNICATIONS
(2023)
