Article
Cell Biology
Junnan Liang, Tongtong Liu, Jingyu Liao, Lu Zhang, Mi Zhou, Weiqi Xu, Yi He, Guangzhen Cai, Guannan Jin, Jia Song, Ganxun Li, Huifang Liang, Zeyang Ding, Bixiang Zhang
Summary: The study identified a CIMP-related methylation signature specific for CCA (CMSC) that can classify patients into different risk groups and predict patient outcomes. Additionally, a subset of patients with an unfavorable prognosis correlated with CIMP-H was identified. Gene enrichment analysis suggested a potential mechanism of CIMP as a promoter of carcinogenesis by regulating proliferation.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Oncology
Jaqueline Loaeza-Loaeza, Berenice Illades-Aguiar, Oscar del Moral-Hernandez, Yaneth Castro-Coronel, Marco A. Leyva-Vazquez, Roberto Dircio-Maldonado, Julio Ortiz-Ortiz, Daniel Hernandez-Sotelo
Summary: This study analyzed the methylation of 8 genes involved in maintaining cell normality and found that high CIMP is significantly associated with the risk of HSIL and CC.
CLINICAL EPIGENETICS
(2022)
Article
Biochemical Research Methods
Pratik Goswami, Martin Bartas, Matej Lexa, Natalia Bohalova, Adriana Volna, Jiri Cerven, Veronika Cervenova, Petr Pecinka, Vladimir Spunda, Miroslav Fojta, Vaclav Brazda
Summary: By analyzing high-frequency mutations of SARS-CoV-2 and their overlay with IR and CpG island loci, this study found that hot-spot mutations of the virus are significantly enriched within these regions. The hypothesis is that hypermethylation of CpG islands may decrease the transcription of viral ORFs and therefore limit the progression of the disease.
BRIEFINGS IN BIOINFORMATICS
(2021)
Article
Biotechnology & Applied Microbiology
Alex de Mendoza, Trung Viet Nguyen, Ethan Ford, Daniel Poppe, Sam Buckberry, Jahnvi Pflueger, Matthew R. Grimmer, Sabine Stolzenburg, Ozren Bogdanovic, Alicia Oshlack, Peggy J. Farnham, Pilar Blancafort, Ryan Lister
Summary: Researchers used epigenome engineering techniques to directly test the effect of induced DNA methylation on endogenous promoters. They found that the transcriptional responses to DNA methylation were highly context-specific, and some regulatory networks could override DNA methylation. The study also demonstrated that induced DNA methylation could exist simultaneously with active histone modifications or DNA bound by RNA polymerase II.
Review
Biochemistry & Molecular Biology
Amirhossein Davoodvandi, Banafsheh Nikfar, Russel J. Reiter, Zatollah Asemi
Summary: Melatonin plays important roles in mammals, regulating circadian rhythms, enhancing immunity, and inhibiting cancer. Epigenetic drugs have gained attention for their potential in cancer treatment. This report summarizes the effects of melatonin on DNA methylation in cancer cells and discusses the impact of artificial light on melatonin secretion and cancer cell DNA methylation.
CELLULAR & MOLECULAR BIOLOGY LETTERS
(2022)
Review
Oncology
Ahmad Ozair, Vivek Bhat, Reid S. Alisch, Atulya A. Khosla, Rupesh R. Kotecha, Yazmin Odia, Michael W. McDermott, Manmeet S. Ahluwalia
Summary: Brain tumors, particularly gliomas, are a diverse group of tumors, with low-grade gliomas being less invasive and having better survival rates compared to high-grade gliomas. This state-of-the-art review summarizes the current understanding of the role of epigenetics, specifically DNA methylation and histone modification, in the pathogenesis, clinical behavior, and outcomes of low-grade gliomas. The review also highlights potential therapeutic targets in associated cellular biomolecules, structures, and processes.
Article
Agriculture, Dairy & Animal Science
Shijie Sun, Zhenhua Shen, Suyu Jin, Lin Huang, Yucai Zheng
Summary: The molecular mechanism of male sterility in yak hybrids was explored based on HAT1 and HDAC1. The mRNA and protein expression levels of HAT1 were significantly lower in cattle-yaks compared to yaks, while the protein expression levels of HDAC1 were significantly higher. Additionally, the acetylation levels of H3K9 in cattle-yak testes were significantly lower than in yaks. These findings suggest that the decreased level of HAT1 and increased level of HDAC1 may contribute to the decreased acetylation levels in cattle-yak testes and their sterility.
Article
Microbiology
Miao Liu, Lingyao Du, Xing Cheng, Man Yuan, Jin Shang, Ying Shi, Hailing Yang, Hong Tang
Summary: This study revealed that the expression of SOCS-1 is decreased in HCV-HCC tissues, and that higher HCV viral load is associated with lower SOCS-1 expression. It was also found that HCV infection can upregulate the methylation of the SOCS-1 gene, which may contribute to the downregulation of SOCS-1 in HCV-infected tissues and cell lines. These findings provide insights into the mechanism of HCV-induced hepatocellular carcinoma.
FRONTIERS IN MICROBIOLOGY
(2022)
Review
Oncology
Xiaofei Zhang, Wenjun Zhang, Pingan Cao
Summary: As the population ages in China, the incidence of colorectal cancer is on the rise, with CpG island methylator phenotype (CIMP) playing an important role in its development. Recent studies have shown a close relationship between CIMP and specific clinicopathological phenotypes and multiple molecular phenotypes in colorectal cancer. This paper introduces the latest progress on CIMP colorectal cancer in terms of chemotherapeutic drugs, targeted agents, and small molecular methylation inhibitors, aiming to provide potential clinical treatment strategies for personalized and precise treatment of colorectal cancer patients.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemical Research Methods
Josephine Yates, Valentina Boeva
Summary: This study utilized a pan-cancer approach to define and explore CpG island methylator phenotype (CIMP) in 26 cancer types. The results confirmed the existence of CIMP in 19 cancers, showed its association with survival differences in eight cancer types, and identified potential drivers of CIMP. The study also found that CIMP was strongly correlated with tumor microenvironment characteristics.
BRIEFINGS IN BIOINFORMATICS
(2022)
Review
Food Science & Technology
Nadir Mustafa Qadir Nanakali, Parisa Maleki Dana, Fatemeh Sadoughi, Zatollah Asemi, Mehran Sharifi, Reza Asemi, Bahman Yousefi
Summary: Natural products such as curcumin, quercetin, and resveratrol have antitumor effects and can affect cancer-related mechanisms, including DNA methylation. These compounds have the potential to be used as cancer treatments by targeting DNA methylation and modifying the expression of tumor suppressor genes.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Gastroenterology & Hepatology
Rossella Tricarico, Jozef Madzo, Gabrielle Scher, Maya Cohen, Jaroslav Jelinek, Shinji Maegawa, Rajeswari Nagarathinam, Carly Scher, Wen-Chi Chang, Emmanuelle Nicolas, Michael Slifker, Yan Zhou, Karthik Devarajan, Kathy Q. Cai, Tim Kwok, Pamela Nakajima, Jinfei Xu, Pietro Mancuso, Valentina Doneddu, Luigi Bagella, Riley Williams, Siddharth Balachandran, Nicholas Maskalenko, Kerry Campbell, Xueying Ma, Israel Canadas, Julen Viana-Errasti, Victor Moreno, Laura Valle, Sergei Grivennikov, Iuliia Peshkova, Natalia Kurilenko, Aleksandra Mazitova, Ekaterina Koltsova, Hayan Lee, Martin Walsh, Reuben Duttweiler, Johnathan R. Whetstine, Timothy J. Yen, Jean-Pierre Issa, Alfonso Bellacosa
Summary: Aberrant DNA methylation is common in colorectal cancer (CRC), but the underlying mechanisms and pathological consequences are not well understood. In this study, disruption of the Tet1 and/or Tdg genes in mice resulted in increased size and invasive features of colonic adenomas. Furthermore, Tet1 and Tdg mutations led to global DNA hypomethylation and CpG island hypermethylation in colonic adenomas. The mutations also upregulated inflammatory, immune, and interferon response genes.
Article
Biochemistry & Molecular Biology
Tarek K. Motawi, Shohda A. El-Maraghy, Dina Sabry, Omina M. Nady, Mahmoud A. Senousy
Summary: The study found that cromolyn chitosan nanoparticles (CSNPs) may have the potential as an epigenetic drug by inhibiting ERK1/2 phosphorylation and DNA methylation. In in vitro and in vivo experiments, cromolyn CSNPs showed significant anticancer effects and influenced the expression of DNMT1 and METTL3, impacting DNA and RNA methylation.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Ecology
Marco Gerdol, Claudia La Vecchia, Maria Strazzullo, Pasquale De Luca, Stefania Gorbi, Francesco Regoli, Alberto Pallavicini, Enrico D'Aniello
Summary: DNA methylation is a crucial epigenetic mechanism that regulates gene expression in all organisms. In metazoans, the pattern of DNA methylation changes during embryogenesis and adulthood, leading to the development of a stable and unique methylation pattern in differentiated cells. The study sheds light on DNA methylation regulators in Mytilus galloprovincialis, providing insights into the role of this mechanism in bivalve genome regulation.
FRONTIERS IN ECOLOGY AND EVOLUTION
(2021)
Article
Chemistry, Multidisciplinary
Yi Zeng, Yujia Mao, Yanjun Chen, Yuhong Wang, Shoujun Xu
Summary: Super-resolution force spectroscopy reveals that single cytosine methylation increases DNA mechanical stability and induces significant chiral selectivity in drug binding. This finding is important for drug design.
CHEMICAL COMMUNICATIONS
(2023)
Article
Engineering, Aerospace
Xingyu Zhou, Tong Qin, Mingjiang Ji, Dong Qiao
Summary: This paper proposes a novel framework for efficiently solving continuously maneuvering spacecraft orbit determination (OD) problems. It combines the Long Short-Term Memory (LSTM) neural network and filter algorithms. The LSTM is trained to detect unknown maneuvers and estimate coefficients of a polynomial representation for a more accurate estimation. The framework is successfully applied to solve Low-Earth-orbit and Middle-Earth-orbit OD problems, accurately tracking maneuvering targets and estimating unknown maneuvers. Numerical simulations show the LSTM can be applied to scenarios with common features to the training dataset.
Article
Chemistry, Medicinal
Tong Qin, Xuefeng Gao, Lei Lei, Wenxuan Zhang, Jing Feng, Xing Wang, Zhufang Shen, Zhenming Liu, Yi Huan, Song Wu, Jie Xia, Liangren Zhang
Summary: In this study, 52 derivatives were designed and synthesized to evaluate their FXR transactivation activity. Twelve FXR agonists showed superior or comparable activity to XJ034, and two compounds had over 9-fold activity and were as potent as OCA. The lead compound, adamantan-1-yl(4-(2-amino-5-chlorophenyl)piperazin-1-yl)methanone (10a, EC50: 1.05 mu M), exhibited better efficacy in improving NAFLD in a mouse model compared to XJ034.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Engineering, Electrical & Electronic
Xiaonan Li, Wenxu Zhang, Hong Wang, Xiping Ma, Hongliang Zhang, Kangle Li, Tong Qin, Kai Liu, Yan Yang, Guangning Wu
Summary: This paper investigates the effect of partial discharge on oil-impregnated Nomex paper in high-frequency transformers. The study analyzes the surface morphology and damage mechanism, finding that the damage degree of oil-paper insulation under high-frequency stress is higher due to the destruction of the benzene ring.
JOURNAL OF ELECTRONIC MATERIALS
(2023)
Article
Materials Science, Ceramics
Qin Tong, Song Liu, Jichuan Huo, Xingquan Zhang, Yongchang Zhu, Aiming Zhang
Summary: Simulated actinides basaltic glasses were prepared using Nd, Ce and La to simulate Am, Np and U in a Chinese power reactor. The results showed that up to 36 wt.% of simulated actinides can be loaded in the glasses, with excess leading to oxyapatite crystal precipitation. Approximately half of Ce4+ was reduced to Ce3+, and the simulated actinides had no serious effects on Si-O bonds in glass networks. The thermal stability of the glasses initially increased with the content of simulated actinides, but decreased when the content exceeded 25 wt.%. All the samples exhibited good leaching resistance, with Nd, Ce and La leaching rates 4 orders of magnitude lower than Si and Na.
JOURNAL OF NON-CRYSTALLINE SOLIDS
(2023)
Article
Materials Science, Multidisciplinary
Qin Tong, Song Liu, Jichuan Huo, Xingquan Zhang, Haifeng Liu, Kui Zheng, Zhu Cui, Yongchang Zhu
Summary: The Nd3+-basaltic glass was prepared to simulate trivalent actinides. The structure, thermal stability, and leaching characteristics of the glass were investigated by XRD, SEM-EDX, Raman, and DSC. The results showed that up to 30 wt.% of Nd2O3 can be loaded in the glass, and oxy-silicate apatite precipitates when the Nd2O3 content reaches 32 wt.%. The addition of Nd2O3 affects the Si-O-Si bond but has little effect on the glass network structure. The leaching resistance of the glass was evaluated by the ASTM PCT Method and showed good performance, with Na showing the highest mass loss after 28 days.
JOURNAL OF NUCLEAR MATERIALS
(2023)
Article
Chemistry, Medicinal
Tong Qin, Xuefeng Gao, Lei Lei, Jing Feng, Wenxuan Zhang, Yuhua Hu, Zhufang Shen, Zhenming Liu, Yi Huan, Song Wu, Jie Xia, Liangren Zhang
Summary: In this study, a novel potential drug target for nonalcoholic fatty liver disease (NAFLD) named Farnesoid X receptor (FXR) agonist was discovered through the development of a multi-stage computational workflow. The compound identified as the representative showed potent FXR agonistic activity in HEK293T cells and demonstrated positive effects on hypercholesterolemia, hepatic steatosis, hyperglycemia, and insulin resistance (IR) in high-fat-diet induced obese (DIO) mice.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
Qihong Yang, Tong Qin, Tao An, Hongna Wu, Gang Xu, Jin Xiang, Kangfan Lei, Shaohua Zhang, Jie Xia, Guifeng Su, Dan Wang, Minggao Xue, Lingmei Kong, Wenxuan Zhang, Song Wu, Yan Li
Summary: In this study, researchers designed a series of pyridonyl acetamide compounds and discovered a novel PORCN inhibitor WHN-88 with a unique di-iodinated pyridone structural fragment. WHN-88 effectively abolished palmitoylation of Wnt ligands and prevented their secretion and the subsequent Wnt/13-catenin signaling transduction. Furthermore, WHN-88 demonstrated potent efficacy against Wnt-driven cancers and inhibited cancer cell stemness.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Review
Forestry
Tong Qin, Liqin Liu, Haibing Cao, Shuangxi Nie, Bin Lu, Zhengbai Cheng, Hongbin Liu, Xingye An
Summary: This paper discusses and reviews the mechanisms of tissue creping technology, as well as the factors that impact the creping process and tissue properties. It is indicated that the creping process can be significantly enhanced through the concerted efforts of various factors. However, further endeavors are necessary to address the constraints stemming from the pilot experimental equipment and data, as well as modeling simulation, to enable a more comprehensive examination of the creping process and its mechanism.
EUROPEAN JOURNAL OF WOOD AND WOOD PRODUCTS
(2023)
Article
Optics
Lintao Peng, Siyu Xie, Tong Qin, Lu Cao, Liheng Bian
Summary: Recently developed image-free sensing techniques are highly effective in various vision tasks, but they still struggle to obtain comprehensive information about objects. In this study, we introduce a novel image-enabled approach that allows efficient and accurate multi-object detection from a limited number of measurements without the need for complex image reconstruction. By optimizing pattern sampling and using a transformer-based network design, our proposed method achieves superior image-free sensing accuracy and object detection performance. Experimental results on the Voc dataset demonstrate an 82.41% mAP detection accuracy at a 5% sampling rate and 63 f.p.s. refresh rate.
Article
Optics
Liheng Bian, Xin Wang, Xuyang Chang, Zhijie Gao, Tong Qin
Summary: In this Letter, we report an iterative framework for noise-robust phase retrieval with high fidelity. By investigating nonlocal structural sparsity in the complex domain and using low-rank regularization, artifacts caused by noise are effectively suppressed. The joint optimization of sparsity regularization and data fidelity with forward models enables satisfying detail recovery.
Article
Green & Sustainable Science & Technology
Shangwen Liu, Shijie Zhou, Hao Guan, Qian-Ming Zhang, Tong Qin, Jiarong Lin
Summary: This paper provides a comprehensive analysis of the relationship between customers' quality preference for product-service, R&D investment, and product-service price. The results show that an enterprise's absorptive capacity positively influences market demand and profit, while negatively impacting competitors. A higher customers' quality preference coefficient indicates a stronger competitive advantage. Implementing a non-cooperative R&D strategy helps enterprises expand their R&D investment scale and accumulate knowledge and technology, leading to increased sales volume and profits. The paper suggests that enterprises should focus on improving absorptive capacity, diversifying R&D strategy, and considering customers' quality preferences and market demand when making R&D investment decisions.
Article
Chemistry, Analytical
Huihui Shao, Jing Feng, Hanyilan Zhang, Yuanyuan Zhang, Tong Qin, Yuhua Hu, Wenxuan Zhang, Tiesong Wang, Song Wu, Qingyun Yang
Summary: In this study, the development and validation of reliable and selective HPLC and HPLC-MS/MS methods for the quantitative analysis of impurities in the drug IMM were described. Five minor impurities were identified and analyzed using spectroscopic evidence, chemical synthetic methods, and LC-MS/MS. The methods showed satisfactory linearity, precision, and repeatability, and the recommended procedures were applied to the existing active pharmaceutical ingredients of IMM, generating satisfactory results.
JOURNAL OF ANALYTICAL METHODS IN CHEMISTRY
(2023)
Article
Veterinary Sciences
Ying Liu, Yanlong Su, Zhijie Zhou, Jie Zhu, Qianqian Zhu, Peng Xie, Shiquan Qian, Liwei Wang, Tong Qin, Gang Zhou
Summary: The study investigated the immune activity and molecular mechanisms related to the hygiene hypothesis in Meishan pigs raised under normal captivity or free-range conditions. Significant differences in cytokine levels and gene expression profiles were observed between the two groups. The identification of specific genes and metabolites associated with immune-related pathways provides new insight into the regulation of cellular immunity and the hygiene hypothesis.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Chemistry, Organic
Min Zeng, Fuli Huang, Minghui Zhu, Jichao Ding, Tong Qin, Maoting Xu, Wanqing Liu, Jun Lu, Jicheng Wu, Xurong Qin, Qiao Ren
Summary: Despite the availability of chemical feedstocks, developing useful cross-coupling reactions with methyl esters as acyl electrophiles is still challenging due to their chemical inertness. We present a simple nickel-catalyzed intramolecular alkene hydroacylation method for the efficient synthesis of various medicinally active indanone and indazolone derivatives. This approach offers good functional group tolerance, easy post-synthetic modifications, total synthesis, and fluorescent probe synthesis. Preliminary in vitro antioxidant evaluation reveals promising free radical scavenging activities of 2-(4-dimethylaminophenyl)-1-indanone and 2-aryl-3-indazolone derivatives.
ORGANIC CHEMISTRY FRONTIERS
(2023)
Correction
Materials Science, Composites
C. Li, J. Huang, T. Qin, C. Chen, L. Gao, J. Xu
JOURNAL OF COMPOSITE MATERIALS
(2023)
