☆ 4.7 Letter

Focus on the importance of soluble human leukocyte antigen G as a marker for embryo selection in assisted reproductive technology

FERTILITY AND STERILITY (2013)

Journal

FERTILITY AND STERILITY

Volume 100, Issue 6, Pages E43-E43

Publisher

ELSEVIER SCIENCE INC

DOI: 10.1016/j.fertnstert.2013.10.013

Keywords

-

Categories

Obstetrics & Gynecology Reproductive Biology

Ask authors/readers for more resources

Protocol

Community support

Reagent

Community support

Authors

I am an author on this paper

Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.7

Not enough ratings

Secondary Ratings

Novelty

-

Significance

-

Scientific rigor

-

Rate this paper

Recommended

Review Immunology

Association of parental HLA-G polymorphisms with soluble HLA-G expressions and their roles on recurrent implantation failure: A systematic review and meta-analysis

Lian Hu, Dongmei He, Hong Zeng

Summary: HLA-G plays a central role in immune tolerance at the maternal-fetal interface and its polymorphism is associated with sHLA-G expression and the risk of recurrent implantation failure (RIF). However, the association of HLA-G polymorphisms with RIF in the general population is unclear and may vary among different ethnic backgrounds. Future studies should consider a combined genetic effect to confirm the association of HLA-G polymorphisms and sHLA-G expressions in relation to RIF.

FRONTIERS IN IMMUNOLOGY (2022)

Add to Collection

Article Multidisciplinary Sciences

Soluble HLA-G (sHLA-G) measurement might be useful as an early diagnostic biomarker and screening test for gastric cancer

Lidy Vannessa Mejia-Guarnizo, Paula Stefanny Monroy-Camacho, Daniel Esteban Rincon-Rodriguez, Andres Rincon-Riveros, Daniel Augusto Martinez-Vargas, Carlos Alexander Huertas-Caro, Ricardo Oliveros-Wilches, Ricardo Sanchez-Pedraza, Marcela Nunez-Lemus, Carlos Felipe Cristancho-Lievano, Adriana Milena Castellanos-Moreno, Lina Maria Martinez-Correa, Josefa Antonia Rodriguez-Garcia

Summary: Gastric cancer (GC) is a commonly occurring malignancy with high mortality due to late diagnosis. Overexpression of the HLA-G molecule in cancer is associated with immune evasion, metastasis, poor prognosis, and lower overall survival. Our study evaluated the plasma levels of soluble HLA-G in patients with GC and benign gastric pathologies, finding higher sHLA-G concentration in GC patients compared to benign pathologies, higher levels in women with GC than men, and significant differences between the benign gastric pathologies assessed. Although sHLA-G is not an adequate marker for staging GC, it has diagnostic potential. Additionally, our study revealed the presence of HLA-G molecules in exosomes, highlighting the need for further research to explore their functional implications and potential non-invasive diagnostic applications.

SCIENTIFIC REPORTS (2023)

Add to Collection

Review Biochemistry & Molecular Biology

Oxidative Stress in Assisted Reproductive Techniques, with a Focus on an Underestimated Risk Factor

Peter Mauchart, Reka Anna Vass, Bernadett Nagy, Endre Sulyok, Jozsef Bodis, Kalman Kovacs

Summary: Based on current findings, this review provides a comprehensive overview of the impact of oxidative stress on the quality of gametes and embryos during assisted reproductive techniques (ART). It discusses the origins of reactive oxygen species (ROS), mechanisms of oxidative stress-induced damage, and the underestimated hazard of light exposure-related photo-oxidation. The review also emphasizes the role and significance of antioxidants and light protection in the development of gametes and embryos in vivo and in vitro.

CURRENT ISSUES IN MOLECULAR BIOLOGY (2023)

Add to Collection

Review Agriculture, Dairy & Animal Science

Review: Reproductive physiology of bison and application of assisted reproductive technologies to their conservation

Carolina Acevedo, Jennifer P. Barfield

Summary: To conserve the important species of bison in Europe and North America, conservation efforts have focused on establishing sustainable herds through the use of assisted reproductive technologies (ARTs). These technologies facilitate the transfer of genetics and offer protection against future losses of genetic diversity. Research on ART for bison has made progress, but there are still opportunities for improvement and expanding their impact on bison conservation.

ANIMAL (2023)

Add to Collection

Review Agriculture, Dairy & Animal Science

Review: Reproductive physiology of bison and application of assisted reproductive technologies to their conservation

Carolina Acevedo, Jennifer P. Barfield

Summary: Bison are important species ecologically and culturally, and conservation efforts are focused on building sustainable herds using assisted reproductive technologies. This review discusses the current state of ART in American bison and European bison, highlighting the potential for genetic conservation and the need for further improvement and expansion of these technologies.

ANIMAL (2023)

Add to Collection

Article Obstetrics & Gynecology

International Committee for Monitoring Assisted Reproductive Technologies world report: assisted reproductive technology, 2014

Georgina M. Chambers, Silke Dyer, Fernando Zegers-Hochschild, Jacques de Mouzon, Osamu Ishihara, Manish Banker, Ragaa Mansour, Markus S. Kupka, G. David Adamson

Summary: In 2014, 1.93 million ART cycles were performed in 76 countries, with trends showing increased success rates, frozen embryo transfer cycles, single embryo transfer, and preimplantation genetic testing. Utilization rates and effectiveness of ART continue to improve globally.

HUMAN REPRODUCTION (2021)

Add to Collection

Review Immunology

HLA-G and the MHC Cusp Theory

Bruna Miglioranza Scavuzzi, Vincent van Drongelen, Joseph Holoshitz

Summary: Human leukocyte antigens (HLA) are important genetic risk factors in many diseases, but the mechanisms underlying their associations remain unclear. The MHC Cusp theory posits that in addition to antigen presentation, MHC codes for allele-specific molecules that can trigger MHC-associated diseases through interactions with receptors. Empirical evidence has supported this theory in several HLA-Class II-associated autoimmune diseases.

FRONTIERS IN IMMUNOLOGY (2022)

Add to Collection

Article Cardiac & Cardiovascular Systems

Maternal Risk of Cardiovascular Disease After Use of Assisted Reproductive Technologies

Maria C. Magnus, Abigail Fraser, Siri E. Haberg, Kristiina Rono, Liv Bente Romundstad, Christina Bergh, Anne Laerke Spangmose, Anja Pinborg, Mika Gissler, Ulla-Britt Wennerholm, Bjorn Olav Asvold, Deborah A. Lawlor, Signe Opdahl

Summary: This study examines the associations between different combinations of aerobic and muscle strengthening activity with mortality rates. The findings suggest that balanced levels of aerobic activity and muscle strengthening may reduce the risk of mortality.

JAMA CARDIOLOGY (2023)

Add to Collection

Article Cardiac & Cardiovascular Systems

Maternal Risk of Cardiovascular Disease After Use of Assisted Reproductive Technologies

Maria C. Magnus, Abigail Fraser, Siri E. Haberg, Kristiina Rono, Liv Bente Romundstad, Christina Bergh, Anne Laerke Spangmose, Anja Pinborg, Mika Gissler, Ulla-Britt Wennerholm, Bjorn Olav Asvold, Deborah A. Lawlor, Signe Opdahl

Summary: A study using nationwide data from Denmark, Finland, Norway, and Sweden found that women who gave birth after assisted reproductive technologies (ART) did not have an increased risk of cardiovascular disease (CVD) compared to those who conceived without ART during a median follow-up of 11 years. Longer-term studies are needed to further investigate the association between ART and higher risk of CVD.

JAMA CARDIOLOGY (2023)

Add to Collection

Article Multidisciplinary Sciences

Involvement of circulating soluble HLA-G after liver transplantation in the low immunogenicity of hepatic allograft

Bastien Le Floc'h, Nathalie Costet, Nicolas Vu, Penelope Bernabeu-Gentey, Charlotte Pronier, Pauline Houssel-Debry, Karim Boudjema, Virginie Renac, Michel Samson, Laurence Amiot

Summary: Graft rejection is a critical risk in solid-organ transplantation. However, liver transplantation may have lower rejection risk due to early elevated levels of HLA-G, leading to a decrease in anti-HLA antibodies.

PLOS ONE (2023)

Add to Collection

Article Reproductive Biology

Development of assisted reproductive technologies for Mus spretus

Ayumi Hasegawa, Keiji Mochida, Shogo Matoba, Kimiko Inoue, Daiki Hama, Masayo Kadota, Noriko Hiraiwa, Atsushi Yoshiki, Atsuo Ogura

Summary: This study developed assisted reproductive technologies for wild-derived Mus spretus mice, enabling efficient production of embryos and successful interspecies embryo transfer into laboratory mice, demonstrating the potential for safe preservation and utilization of strains in research settings.

BIOLOGY OF REPRODUCTION (2021)

Add to Collection

Article Obstetrics & Gynecology

International Committee for Monitoring Assisted Reproductive Technologies (ICMART): world report on assisted reproductive technologies, 2013

Manish Banker, Silke Dyer, Georgina M. Chambers, Osamu Ishihara, Markus Kupka, Jacques de Mouzon, Fernando Zegers-Hochschild, G. David Adamson

Summary: The report provides data on the utilization, effectiveness, and safety of assisted reproductive technology (ART) globally in 2013, showing an increase in ART cycles and changes in trends such as a rise in the proportion of older women undergoing non-donor ART. Further efforts are needed to improve the quality and consistency of reporting ART data by registries.

FERTILITY AND STERILITY (2021)

Add to Collection

Review Agriculture, Dairy & Animal Science

Current status of assisted reproductive technologies in buffaloes

Kanokwan Srirattana, Danilda Hufana-Duran, Eufrocina P. Atabay, Peregrino G. Duran, Edwin C. Atabay, Kehuan Lu, Yuanyuan Liang, Thuchadaporn Chaikhun-Marcou, Kasem Theerakittayakorn, Rangsun Parnpai

Summary: Buffalo production is receiving more attention and interest due to its socioeconomic impact and contribution to the livestock industry in developing countries. However, buffalo reproduction faces challenges and concerns, including poor estrus manifestation and low reproductive efficiency compared to cattle. Assisted reproductive technologies (ARTs) play a major role in improving buffalo reproduction.

ANIMAL SCIENCE JOURNAL (2022)

Add to Collection

Review Immunology

Role of HLA-G in Viral Infections

Simon Jasinski-Bergner, Dominik Schmiedel, Ofer Mandelboim, Barbara Seliger

Summary: This review provides a summary of the expression, regulation, function, and impact of HLA-G in the context of different viral infections, including virus-associated cancers. It emphasizes the potential use of HLA-G as a novel diagnostic and prognostic biomarker for viral infections, as well as a therapeutic target.

FRONTIERS IN IMMUNOLOGY (2022)

Add to Collection

Article Immunology

Circulating Placental Vesicles Carry HLA-DR in Pre-Eclampsia: A New Potential Marker of the Syndrome

Chiara Tersigni, Donatella Lucchetti, Rita Franco, Filomena Colella, Caterina Neri, Laura Crispino, Alessandro Sgambato, Antonio Lanzone, Giovanni Scambia, Manu Vatish, Nicoletta Di Simone

Summary: PE is a common pregnancy disorder characterized by hypertension and proteinuria, with aberrant expression of HLA-DR in STBEVs specifically associated with PE. Further studies are needed to define the role of abnormal placental HLA-DR expression in PE pathogenesis and evaluate the potential application of detecting circulating HLA-DR positive STBEVs in diagnosing and predicting PE in early and mid-pregnancy.

FRONTIERS IN IMMUNOLOGY (2021)

Add to Collection

Article Medicine, Research & Experimental

Inhibitory KIR2DL2 receptor and HHV-8 in classic or endemic Kaposi sarcoma

Daria Bortolotti, Monica Corazza, Antonella Rotola, Dario Bencivelli, Giovanna Schiuma, Elisabetta Danese, Sabrina Rizzo, Silvia Beltrami, Roberta Rizzo, Alessandro Borghi

Summary: The results of the study suggest that KIR2DL2 and HHV8 infection may be associated with the development of classical KS, and may act as a co-factor in increasing the risk of developing c-KS in HHV8-positive, immunocompetent individuals. However, the role of KIR2DL2 seems to be less relevant in the pathogenesis of endemic KS.

CLINICAL AND EXPERIMENTAL MEDICINE (2023)

Add to Collection

Article Peripheral Vascular Disease

COVID-19 induced aorto duodenal fistula following evar in the so called negative patient

Luca Traina, Marianna Mucignat, Roberta Rizzo, Roberta Gafa, Daria Bortolotti, Angelina Passaro, Paolo Zamboni

Summary: The SARS-CoV-2 pandemic has posed challenges for the international healthcare system and patient treatment and survival. This article presents a case of a so called Covid-19 negative patient who exhibited an unsuspected vascular clinical onset of the viral infection.

VASCULAR (2023)

Add to Collection

Review Immunology

Factors associated with fertility abnormalities in women with systemic lupus erythematosus: a systematic review and meta-analysis

S. Giambalvo, C. Garaffoni, E. Silvagni, F. Furini, R. Rizzo, M. Govoni, A. Bortoluzzi

Summary: This systematic literature review aimed to explore the factors associated with fertility outcomes in women of childbearing age with systemic lupus erythematosus (SLE). The study found that exposure to cyclophosphamide and its cumulative dose can impair gonadal function in SLE women, leading to amenorrhea and premature ovarian failure (POF). Certain treatments were associated with a lower risk of POF. Hormonal and serological factors did not appear to impact fertility outcomes, but could be used as surrogate markers of fertility.

AUTOIMMUNITY REVIEWS (2022)

Add to Collection

Article Clinical Neurology

Investigating Serum sHLA-G Cooperation With MRI Activity and Disease-Modifying Treatment Outcome in Relapsing-Remitting Multiple Sclerosis

Roberta Amoriello, Roberta Rizzo, Alice Mariottini, Daria Bortolotti, Valentina Gentili, Elena Bonechi, Alessandra Aldinucci, Alberto Carnasciali, Benedetta Peruzzi, Anna Maria Repice, Luca Massacesi, Enrico Fainardi, Clara Ballerini

Summary: Relapsing-remitting multiple sclerosis (RRMS) is associated with the HLA-G gene, which may play a role in regulating the disease. The study found that serum sHLA-G level is influenced by genotype and has an impact on treatment and MRI activity, but is not correlated with peripheral inflammation.

FRONTIERS IN NEUROLOGY (2022)

Add to Collection

Article Virology

Competition for dominance within replicating quasispecies during prolonged SARS-CoV-2 infection in an immunocompromised host

Francesca Caccuri, Serena Messali, Daria Bortolotti, Dario Di Silvestre, Antonella De Palma, Chiara Cattaneo, Anna Bertelli, Alberto Zani, Maria Milanesi, Marta Giovanetti, Giovanni Campisi, Valentina Gentili, Antonella Bugatti, Federica Filippini, Erika Scaltriti, Stefano Pongolini, Alessandra Tucci, Simona Fiorentini, Pasqualina d'Ursi, Massimo Ciccozzi, Pierluigi Mauri, Roberta Rizzo, Arnaldo Caruso

Summary: A study found that there is a dynamic interplay between major and minor variants of the novel coronavirus in immunocompromised patients, with minor variants gradually replacing the major variant during infection and using different entry mechanisms into host cells. Minor variants may have a faster replication activity and induce specific viral RNA-sensing mechanisms, leading to increased interferon production. This finding may explain the rapid global spread of SARS-CoV-2 variants.

VIRUS EVOLUTION (2022)

Add to Collection

Article Microbiology

Herpesvirus Infections in KIR2DL2-Positive Multiple Sclerosis Patients: Mechanisms Triggering Autoimmunity

Daria Bortolotti, Valentina Gentili, Alessandra Bortoluzzi, Marcello Govoni, Giovanna Schiuma, Silvia Beltrami, Sabrina Rizzo, Eleonora Baldi, Elisabetta Caselli, Maura Pugliatti, Massimiliano Castellazzi, Mercedes Fernandez, Enrico Fainardi, Roberta Rizzo

Summary: In patients with multiple sclerosis, there is an increased susceptibility to human herpesvirus infections, particularly EBV and HHV-6. These viral infections may induce immune activation and trigger autoimmune responses, leading to tissue damage and the development of multiple sclerosis lesions.

MICROORGANISMS (2022)

Add to Collection

Article Microbiology

Innate Immune Response in SARS-CoV-2 Infection

Giovanna Schiuma, Silvia Beltrami, Daria Bortolotti, Sabrina Rizzo, Roberta Rizzo

Summary: A robust innate immune response is crucial for controlling viral infections. Natural Killer (NK) cells, monocytes/macrophages, and neutrophils, which represent the innate immune components, form the first line of defense against the virus. The activation of these components is essential for an effective acquired immune response.

MICROORGANISMS (2022)

Add to Collection

Article Developmental Biology

Effect of SARS-CoV-2 infection in pregnancy on CD147, ACE2 and HLA-G expression

Giovanna Schiuma, Silvia Beltrami, Erica Santi, Gennaro Scutiero, Juana Maria Sanz, Chiara Marina Semprini, Sabrina Rizzo, Mercedes Fernandez, Ines Zidi, Roberta Gafa, Angelina Passaro, Pantaleo Greco, Daria Bortolotti, Roberta Rizzo

Summary: Recent studies have shown differential expression of ACE2 and CD147 in pregnant women with SARS-CoV-2 placental infection. This study aimed to investigate placental SARSCoV-2 infection and its potential effect on protein expression. The results revealed a higher percentage of SARS-CoV-2 NP positive placental samples in the group positive for SARS-CoV-2 at delivery compared to the negative group.

PLACENTA (2023)

Add to Collection

Article Multidisciplinary Sciences

SARS-CoV-2 viral entry and replication is impaired in Cystic Fibrosis airways due to ACE2 downregulation

Valentino Bezzerri, Valentina Gentili, Martina Api, Alessia Finotti, Chiara Papi, Anna Tamanini, Christian Boni, Elena Baldisseri, Debora Olioso, Martina Duca, Erika Tedesco, Sara Leo, Monica Borgatti, Sonia Volpi, Paolo Pinton, Giulio Cabrini, Roberto Gambari, Francesco Blasi, Giuseppe Lippi, Alessandro Rimessi, Roberta Rizzo, Marco Cipolli

Summary: As an inherited disorder characterized by severe pulmonary disease, cystic fibrosis could be considered a comorbidity for coronavirus disease 2019. However, current clinical evidence suggests that cystic fibrosis may actually protect against SARS-CoV-2 infection. The expression of SARS-CoV-2 receptors in primary airway epithelial cells is regulated by the CFTR channel, and dysfunctional CFTR channels in cystic fibrosis cells result in reduced viral entry and replication.

NATURE COMMUNICATIONS (2023)

Add to Collection

Editorial Material Pharmacology & Pharmacy

Editorial: Cell cycle control as a new therapeutic approach for SARS-CoV-2 infection

Roberta Rizzo, Francesca Caccuri, Giuseppe Valacchi, Giorgio Zauli

FRONTIERS IN PHARMACOLOGY (2023)

Add to Collection

Article Plant Sciences

Characterization of Neochloris oleoabundans under Different Cultivation Modes and First Results on Bioactivity of Its Extracts against HCoV-229E Virus

Costanza Baldisserotto, Valentina Gentili, Roberta Rizzo, Chiara Di Donna, Luna Ardondi, Annalisa Maietti, Simonetta Pancaldi

Summary: Microalgae, specifically Neochloris oleoabundans, cultivated under autotrophic and mixotrophic conditions, were found to produce whole aqueous extracts with antiviral properties against HCoV-229E. The extracts contained bioactive compounds such as lipids, exo-polysaccharides, phenolics, proteins, and pigments. The study suggests that the inhibitory effect of the extracts is mainly attributed to the combination of proteins, pigments, and phenolics in autotrophic cultures, and proteins, acidic exo-polysaccharides, and lipids in mixotrophic cultures.

PLANTS-BASEL (2023)

Add to Collection

Review Immunology

Non-classical HLA class I molecules and their potential role in viral infections

Silvia Beltrami, Sabrina Rizzo, Giovanni Strazzabosco, Valentina Gentili, Andrea Alogna, Marco Narducci, Daria Bortolotti, Giovanna Schiuma, Roberta Rizzo

Summary: Human Leukocyte Antigens (HLA) are classified into three different classes I, II and III, and play important roles in immune responses, self-tolerance development and pathogen recognition. Nonclassical subtypes (HLA-Ib), such as HLA-E and HLA-G, have tolerogenic functions that are often exploited by viruses to evade the host immune responses. This review summarizes the current data on HLA-G and HLA-E in viral infections and their impact on immune response.

HUMAN IMMUNOLOGY (2023)

Add to Collection

Editorial Material Microbiology

SARS-CoV-2 Systemic Effects: New Clues

Silvia Beltrami, Sabrina Rizzo, Francesca Caccuri, Roberta Rizzo, Daria Bortolotti, Giovanna Schiuma

MICROORGANISMS (2023)

Add to Collection

Review Microbiology

Gestational Viral Infections: Role of Host Immune System

Silvia Beltrami, Sabrina Rizzo, Giovanna Schiuma, Giorgia Speltri, Dario Di Luca, Roberta Rizzo, Daria Bortolotti

Summary: Viral infections during pregnancy can have serious consequences for both the mother and the fetus. Depending on the timing and type of infection, different clinical manifestations can occur. The unique immunological status of pregnancy allows viruses to exploit and evade the maternal immune system. Understanding the interaction between these viruses and the host's immune system is crucial for prevention, diagnosis, and treatment. This review focuses on the DNA and RNA viruses associated with gestational infections.

MICROORGANISMS (2023)

Add to Collection

Article Health Care Sciences & Services

Perspectives of Italian Physicians and Patients in the Treatment of Otitis Externa: A Real-Life Study

Matteo Gelardi, Rossana Giancaspro, Massimo Landi, Luigi Santoiemma, Maddalena Balestra, Michele Cassano, Roberta Rizzo

Summary: This study aimed to investigate the patient journey of Italian patients suffering from otitis externa (OE), with a focus on new therapeutic options. The results showed that OE is a common, often relapsing disease with antibiotic resistance becoming a growing problem. New liposomal ozone-based preparations were found to be the most-prescribed treatment.

JOURNAL OF PERSONALIZED MEDICINE (2023)

Add to Collection

No Data Available

© Peeref 2019-2024. All rights reserved.