Review
Endocrinology & Metabolism
Veronika Guenther, Soeren V. Otte, Damaris Freytag, Nicolai Maass, Ibrahim Alkatout
Summary: Recurrent Implantation Failure (RIF) is the failure to achieve a clinical pregnancy after transfer of at least four good quality embryos in a minimum of three fresh or frozen cycles in women under the age of 40. It is a complex problem with multiple etiologies and treatment options depending on individual cases.
GYNECOLOGICAL ENDOCRINOLOGY
(2021)
Review
Chemistry, Multidisciplinary
Sean Saramago, Joana Magalhaes, Marina Pinheiro
Summary: Tuberculosis remains a global health challenge, with only one licensed vaccine available. Progress has been made in the development of new TB vaccines, particularly in the field of nanovaccines. Nanovaccines show potential for improving delivery, efficacy, cost, and storage conditions of existing TB vaccines. Further research is needed for the development of novel TB vaccines.
APPLIED SCIENCES-BASEL
(2021)
Article
Obstetrics & Gynecology
Samuel Ojosnegros, Anna Seriola, Amelie L. Godeau, Anna Veiga
Summary: This review explores experimental options proposed in the literature to study human embryo implantation, categorizing them based on the embryo/cell pairs employed. In vitro models offer efficient screening of molecules controlling implantation and endometrial receptivity, but the selection of available systems complicates decision-making. Further advances using stem cells and bioengineering methods hold promise for extending understanding of the implantation process.
HUMAN REPRODUCTION UPDATE
(2021)
Article
Medicine, Research & Experimental
Jack P. Antel, Timothy E. Kennedy, Tanja Kuhlmann
Summary: In this study, the authors investigate the potential of targeting the neuron-oligodendrocyte potassium shuttling as a neuroprotective strategy in multiple sclerosis. They examine disease models, evaluate the impact of pharmacologic intervention, and assess the status in tissues from MS patients. These findings serve as a template for defining a potential protective pathway.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Obstetrics & Gynecology
Amruta D. S. Pathare, Indira Hinduja
Summary: Recurrent implantation failure (RIF) is a major obstacle in IVF treatment. A study was conducted to analyze gene expression in non-pregnant RIF patients vs fertile women under controlled ovarian stimulation (COS), revealing significant downregulation of cell adhesion function and confirming downregulation of six out of eight related genes in RIF patients. These findings suggest the importance of these genes in the endometrial receptivity (ER) mechanism under COS. Additional analysis in larger cohorts is needed to validate the study findings in RIF patients undergoing IVF.
REPRODUCTIVE SCIENCES
(2022)
Article
Obstetrics & Gynecology
Micah J. Hill
Summary: Recurrent implantation failure presents a challenging clinical dilemma with no consensus diagnostic criteria. Current evidence provides some guidance for clinical investigation and treatment, but further research is needed to establish a consensus diagnosis.
FERTILITY AND STERILITY
(2021)
Article
Obstetrics & Gynecology
Genia Rozen, Peter Rogers, Wan Tinn Teh, Catharyn J. Stern, Alex Polyakov
Summary: RIF is a disorder with an imprecise definition lacking robust scientific basis, presenting significant challenges in diagnosis and treatment. The concept of 'Theoretical Cumulative Implantation Rate' is proposed to determine RIF diagnosis based on objective data. An updated and standardized definition is needed for patient counseling and research planning.
HUMAN REPRODUCTION
(2021)
Review
Oncology
Ann Neiheisel, Manpreet Kaur, Nancy Ma, Patty Havard, Anitha K. Shenoy
Summary: The Wnt signaling pathway plays a crucial role in the initiation and progression of various cancers, serving as reliable biomarkers and potential therapeutic targets. The canonical pathway is involved in cell survival and proliferation, while the noncanonical pathway regulates cell polarity and migration. In addition to its biological functions in development and homeostasis, the Wnt pathway is implicated in a range of pathological disorders, particularly cancer.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Obstetrics & Gynecology
Audrey S. Garneau, Steven L. Young
Summary: Recurrent implantation failure (RIF) is a clinical scenario where patients fail to achieve pregnancy after multiple embryo transfers. Studying RIF is challenging due to the diverse causes and definitions of implantation failure, but recent research suggests a personalized approach may be beneficial.
FERTILITY AND STERILITY
(2021)
Editorial Material
Genetics & Heredity
Ghazal Aghagoli, Alexey Fedulov, Julia K. Shinnick
Summary: This article explores the epigenetic changes in uroepithelial cells induced by uropathogenic E. coli, which contribute to recurrent UTIs and have the potential to inform novel therapeutic strategies.
Article
Obstetrics & Gynecology
Paul Pirtea, Marcelle I. Cedars, Kate Devine, Baris Ata, Jason Franasiak, Catherine Racowsky, Jim Toner, Richard T. Scott, Dominique de Ziegler, Kurt T. Barnhart
Summary: To date, there is no clear definition and function impairment of recurrent implantation failure (RIF). Therefore, the term RIF is currently used somewhat haphazardly based on clinicians' judgment. International experts in reproductive medicine met in Lugano, Switzerland, in July 2022 to review RIF and determine its diagnosis and management. Rating: 8/10
FERTILITY AND STERILITY
(2023)
Review
Biochemistry & Molecular Biology
Aleksandra E. Mrozikiewicz, Marcin Ozarowski, Piotr Jedrzejczak
Summary: Infertility affects 8-12% of reproductive age couples worldwide, with a significant impact on women experiencing recurrent implantation failure (RIF). RIF is a complex condition involving various physiological and molecular mechanisms, with studies suggesting associations with hormone level imbalances, disturbances of angiogenic and immunomodulatory factors, certain genetic polymorphisms, and ethnicity-related inconsistencies. This review highlights the importance of factors contributing to RIF development, potentially paving the way for new diagnostic and therapeutic solutions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Medicine, General & Internal
Martina Catalano, Giandomenico Roviello, Ilaria Camilla Galli, Raffaella Santi, Gabriella Nesi
Summary: This review summarizes the current knowledge of immune checkpoint inhibitors (ICIs)-induced nephrotoxicity, emphasizing the underestimated difficulty in diagnosis and discussing the treatment options and future research directions.
FRONTIERS IN MEDICINE
(2022)
Review
Biotechnology & Applied Microbiology
Estela Pineda, Marta Domenech, Ainhoa Hernandez, Silvia Comas, Carmen Balana
Summary: Treating glioblastomas is challenging and there are currently no effective alternative treatments. The main difficulties in treatment arise from the low incidence of the disease, age and neurological symptoms of patients, and issues related to the drugs themselves.
ONCOTARGETS AND THERAPY
(2023)
Review
Gastroenterology & Hepatology
Daniel S. Strand, Ryan J. Law, Dennis Yang, B. Joseph Elmunzer
Summary: The purpose of this study is to provide practical and evidence-based guidance on the role of endoscopy in recurrent acute and chronic pancreatitis, and ensure its accuracy and reliability through peer review.
