Journal
FERTILITY AND STERILITY
Volume 98, Issue 4, Pages 965-+Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.fertnstert.2012.05.048
Keywords
FSH receptor; estrogen receptor; polymorphism; premature ovarian failure; infertility
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Funding
- Swiss National Science Foundation (SNF) [320000-113517/1]
- Repronatal Foundation, Basel, Switzerland
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Objective: To study the distribution of a set of polymorphic alleles of genes encoding key regulators of the menstrual cycle in cohorts of women with different levels of fertility. Design: Prospective cohort study. Setting: University hospital. Patient(s): Two hundred fertile women, who reported to have conceived within 3 months, 348 women with ongoing menstrual cycles suffering of infertility, and 48 infertile women diagnosed with infertility and premature ovarian failure (POF). Intervention(s): Eleven polymorphisms of genes with known associations with surrogate parameters of female ovarian function were analyzed. Main Outcome Measure(s): The prevalence of polymorphic alleles in the three distinct cohorts after adjustment for age. Result(s): The distributions of the allelic variants were compared with the fertility status of the recruited women. Using age-adjusted logistic regression analysis and the Bonferroni correction for multiple corrections, the CC-allele of the PvuII polymorphic variant in intron 1 of the ESR1 gene was twice as prevalent among women suffering from infertility. None of the other polymorphisms were distributed differently among the three cohorts. Conclusion(s): The ESR1-PvuII polymorphism emerges as a potential candidate for the early prediction of infertility due to premature ovarian aging. (Fertil Steril (R) 2012;98:965-72. (C)2012 by American Society for Reproductive Medicine.)
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