Article
Nutrition & Dietetics
Yu Wang, Meizhi Du, Jillian Vallis, Matin Shariati, Patrick S. Parfrey, John R. Mclaughlin, Peizhong Peter Wang, Yun Zhu
Summary: Polymorphic variants in MTRR and MTHFR genes may be associated with survival in patients with CRC, and this gene-CRC outcome association seems to be modulated by alcohol drinking and fruit intake.
Article
Nutrition & Dietetics
Jingyuan Zhang, Chang Zeng, Xia Huang, Qiao Liao, Hengshu Chen, Fan Liu, Dongren Sun, Shihang Luo, Yeqing Xiao, Weiye Xu, Danfeng Zeng, Mingyu Song, Fafa Tian
Summary: This study found that MTHFR rs1801133 gene and Hcy were associated with PSD. MTHFR rs1801133 gene may exert an effect on PSD by mediating Hcy level.
FRONTIERS IN NUTRITION
(2022)
Article
Nutrition & Dietetics
Can Sun, Ding Ding, Zhouyu Wen, Chengmei Zhang, Juan Kong
Summary: There is a dose-response relationship between plasma zinc (Zn) and risk of Hyperhomocysteinemia (HHcy) in patients in Northeast China, with a threshold level of 83.89 mu mol/L for reducing HHcy risk. Therefore, individuals in this region, especially those with the MTHFR 677TT polymorphism, should pay attention to their plasma Zn and homocysteine levels.
Article
Endocrinology & Metabolism
Wanqin Feng, Yan Zhang, Yuan Pan, Yi Zhang, Minjuan Liu, Yuxin Huang, Yuanling Xiao, Wenyu Mo, Junjie Jiao, Xiaoyang Wang, Dan Tian, Lixia Yang, Ying Ma
Summary: The study found a significant dose-dependent association between MTHFR A1298C and PCOS, with MTRR A66G showing nominal association. Mutations in both MTHFR A1298C and MTRR A66G were significantly associated with the homocysteine level. Mediation analysis suggested that the effect of MTHFR A1298C on PCOS is mediated by homocysteine.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2021)
Article
Medicine, Research & Experimental
Tarciana Guedes, Aline A. Santos, Felipe H. Vieira-Neto, Bianca Bianco, Caio P. Barbosa, Denise M. Christofolini
Summary: This study aimed to investigate the correlation between genetic variants, homocysteine levels, and assisted reproduction results. It was found that patients with endometriosis had specific genetic markers, lower levels of homocysteine, and a tendency towards better clinical pregnancy outcomes.
BIOMARKERS IN MEDICINE
(2022)
Article
Clinical Neurology
Dong Guan, Yichun Ji, Xiaoyun Lu, Weiyi Feng, Wenbing Ma
Summary: Genetic variation in the MTHFR gene may contribute to the development of cerebral infarction. This study aimed to analyze the effect of MTHFR gene polymorphism on serum lipid and homocysteine levels among Chinese Han population with cerebral infarction. Results showed that the TT genotype and T allele frequencies were significantly higher among CI patients, and CT/TT carriers had higher homocysteine levels and lower HDL-C and ApoA-I levels.
FRONTIERS IN NEUROLOGY
(2023)
Article
Engineering, Biomedical
Minmin Jiang, Shengwen Huang, Jun Yuan, Xingwen Ma, Xiaoli Wu, Zhaozhen Zhuo, Lingyan Ren, Qian Jin
Summary: The study investigated the association between /WHR C677T, MTHFR A1298C, and MTRR A66G polymorphisms and birth defects in the southern Chinese population. Genotyping was conducted and association analysis revealed that these polymorphisms were not significant risk factors for predicting birth defects. Despite differences in genotype distribution and effects on folic acid and homocysteine levels, the polymorphisms did not play a critical role in predicting birth defects in this study.
JOURNAL OF HARD TISSUE BIOLOGY
(2021)
Article
Medicine, General & Internal
Fawzia A. Saafan, Ayman Z. Elsamanoudy, Dalia Shaalan, Nanees Zeidan, Mohammad A. Gaballah
Summary: This study found that patients with AGA have higher levels of SH, and the C677T polymorphism of MTHFR is associated with an increased risk of CHD. The mutant T allele is correlated with hyperhomocysteinemia and an increased risk of CHD in AGA patients, highlighting the importance of cardiac evaluation and follow-up in this population.
AMERICAN JOURNAL OF THE MEDICAL SCIENCES
(2021)
Article
Obstetrics & Gynecology
Luting Chen, Huixi Chen, Xiaojin Wang, Bing Wei, Zhengmu Wu, Songchang Chen, Bingshun Wang, Hefeng Huang, Li Jin
Summary: The study reveals that there is a significant negative association between total serum Hcy concentration and clinical pregnancy and implantation rate; after adjusting for various factors, it was found that women with higher levels of Hcy also had a higher risk of unsuccessful pregnancy.
REPRODUCTIVE BIOMEDICINE ONLINE
(2021)
Article
Cell Biology
Yaling Jiang, Xuewen Xiao, Yafei Wen, Meidan Wan, Lu Zhou, Xixi Liu, Xin Wang, Lina Guo, Hui Liu, Yafang Zhou, Junling Wang, Xinxin Liao, Lu Shen, Bin Jiao
Summary: The study found that the C677T and A1298C polymorphisms are associated with AD in the Chinese population. Patients with the C677T polymorphism are more likely to have an earlier onset, higher homocysteine levels, and more severe white matter lesions.
Article
Geriatrics & Gerontology
C. Y. T. Kwok, Y. K. P. Poon, P. Chook, D. S. Guo, C. Q. Lin, Y. H. Yin, D. S. Celermajer, K. S. Woo
Summary: This study in China investigated the impact of high homocysteine levels and PM2.5 air pollution on atherosclerosis. The results showed that high homocysteine levels were associated with increased carotid intima-media thickness in areas with high PM2.5 pollution. This finding has important implications for atherosclerosis prevention strategies in China.
JOURNAL OF NUTRITION HEALTH & AGING
(2023)
Article
Oncology
Linjing Zhang, Lili Sun, Tao Wei
Summary: This study investigated the association between MTHFR gene polymorphisms and homocysteine levels in pregnancy-induced hypertension. Results showed that patients with pregnancy-induced hypertension had higher Hcy levels and increased proportion of TT genotype at the MTHFR gene C677T locus, which correlated with higher incidence of abnormal pregnancy outcomes.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Lyazzat Kaldygulova, Talshyn Ukybassova, Gulzhanat Aimagambetova, Andrey Gaiday, Akylbek Tussupkaliyev
Summary: The rationale and importance of folic acid supplementation during pregnancy for preventing fetal congenital defects are widely accepted. Adequate folate levels can reduce the risk of spontaneous abortions and support normal placental blood flow, promoting appropriate fetal growth. Additionally, there is emerging evidence that long-term folic acid supplementation can effectively prevent preeclampsia, a complication unique to humans during pregnancy that contributes to worldwide maternal and perinatal mortality. Folate supplementation helps to decrease elevated levels of homocysteine, which is associated with the risk of preeclampsia.
Article
Pharmacology & Pharmacy
H. -M Hou, X. -J Qin, H. -Y Zhao
Summary: This study investigated the relationship between homocysteine levels and MTHFR C677T polymorphisms with acute ischemic vascular events and focused on the differential effects of the MTHFR C677T polymorphisms on the burden and location of AMI and ACI. The results showed that homocysteine levels were associated with MTHFR C677T polymorphisms and acute ischemic vascular events, but did not differentially affect the burden and location of AMI and ACI.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2023)
Article
Public, Environmental & Occupational Health
Derrick A. Bennett, Sarah Parish, Iona Y. Millwood, Yu Guo, Yiping Chen, Iain Turnbull, Ling Yang, Jun Lv, Canqing Yu, George Davey Smith, Yongjun Wang, Yilong Wang, Richard Peto, Rory Collins, Robin G. Walters, Liming Li, Zhengming Chen, Robert Clarke
Summary: In Chinese adults, the MTHFR C677T polymorphism is associated with an increased risk of stroke, highlighting the importance of further trials involving folic acid and mandatory folic acid fortification programs for stroke prevention in low-folate populations.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Developmental Biology
Sylvie Jaillard, Kenneth McElreavy, Gorjana Robevska, Linda Akloul, Farah Ghieh, Rajini Sreenivasan, Marion Beaumont, Anu Bashamboo, Joelle Bignon-Topalovic, Anne-Sophie Neyroud, Katrina Bell, Elisabeth Veron-Gastard, Erika Launay, Jocelyn van den Bergen, Benedicte Nouyou, Francois Vialard, Marc-Antoine Belaud-Rotureau, Katie L. Ayers, Sylvie Odent, Celia Ravel, Elena J. Tucker, Andrew H. Sinclair
MOLECULAR HUMAN REPRODUCTION
(2020)
Article
Medicine, General & Internal
Emmanuelle Mathieu d'Argent, Celia Ravel, Alexandra Rousseau, Karine Morcel, Nathalie Massin, Julie Sussfeld, Tabassome Simon, Jean-Marie Antoine, Jacqueline Mandelbaume, Emile Darai, Kamila Kolanska
Summary: High-dose folic acid supplementation in men with male infertility undergoing IVF-ICSI has been shown to increase the biochemical pregnancy rate, reduce DNA fragmentation, and potentially improve the clinical pregnancy rate. Despite no observed changes in sperm characteristics, folic acid supplementation appears to have a positive impact on IVF-ICSI outcomes for male infertility patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Urology & Nephrology
L. Freton, Z-E Khene, C. Richard, R. Mathieu, Q. Alimi, E. Duval, L. Vassal, N. Bertheuil, S. Aillet, F. Bonnet, C. Ravel, A. Guenego, D. Travers, N. Morel-Journel, J. Hascoet, B. Peyronnet
Summary: Healthcare professionals in a French university hospital lack comfort in managing trans people, mainly due to a lack of knowledge and training in this area, rather than disagreement with the need for transgender healthcare.
PROGRES EN UROLOGIE
(2021)
Article
Andrology
Florence Eustache, Veronique Drouineaud, Nicolas Mendes, Beatrice Delepine, Charlotte Dupont, Sophie Mirallie, Aline Papaxanthos, Catherine Metzler-Guillemain, Aurelie Rives-Feraille, Fanny Magnan, Cecile Greze, Sylviane Hennebicq, Isabelle Koscinski, Hortense Drapier, Cynthia Frapsauce, Anne Mayeur, Marie-Ange Carlotti, Joffrey Mons, Francoise Schmitt, Pascale May-Panloup, Oxana Blagosklonov, Florence Brugnon, Stephanie Mestres, Rosalie Cabry, Patricia Fauque, Vanessa Loup-Cabaniols, Celia Ravel, Rachel Levy, Catherine Patrat, Emmanuelle Thibault, Nelly Frydman, Louis Bujan, Catherine Moriniere, Berengere Ducrocq, Nathalie Rives
Summary: The study evaluated the distribution of care on the French territory concerning fertility preservation and sperm donation in transgender individuals. Results showed that these assisted reproductive technologies are present throughout France, with significant growth in both fertility preservation and sperm donation for transgender individuals, and improvement in patient care year after year.
Review
Cell Biology
Marina G. Yefimova, Celia Ravel, Antoine D. Rolland, Nicolas Bourmeyster, Bernard Jegou
Summary: Efficient elimination of apoptotic substrates is crucial for tissue homeostasis in the retina, testis, and ovaries, and is achieved by phagocytic cells like RPE, Sertoli cells, and GC. Disruption of this process can lead to functional ablation and vision loss in the retina, and compromised fertility in males and females. Cooperation between TAM RTKs, autophagy-related proteins, LAP, and TLR plays a pivotal role in maintaining tissue homeostasis and preventing functional ablation of these tissues.
Review
Pharmacology & Pharmacy
Amanda K. A. Silva, Marie Morille, Max Piffoux, Surendar Arumugam, Phlippe Mauduit, Jerome Larghero, Arnaud Bianchi, Kelly Aubertin, Olivier Blanc-Brude, Daniele Noel, Emilie Velot, Celia Ravel, Celine Elie-Caille, Anna Sebbagh, Chantal Boulanger, Claire Wilhelm, Gabriel Rahmi, Isabelle Raymond-Letron, Kondareddy Cherukula, Tristan Montier, Christophe Martinaud, Jean-Marie Bach, Olivier Favre-Bulle, Jolanda Spadavecchia, Christian Jorgensen, Philippe Menasche, Clotilde Aussel, Joel Chopineau, Mathilde Mosser, Matti Ullah, Nicolas Sailliet, Nathalie Luciani, Noelle Mathieu, Pierre-Emmanuel Rautou, Sophie Brouard, Wilfrid Boireau, Sebastien Jauliac, Marianne Dedier, Jean-Hugues Trouvin, Florence Gazeau, Marina Trouillas, Juliette Peltzer, Antoine Monsel, Sebastien Banzet
Summary: The translation of EV research into medicinal products presents an exciting and challenging perspective, requiring fulfillment of quality, safety, and efficacy criteria. Active contributions from regulatory agencies, expert networks, and the newly established EVOLVE group in France play important roles in this translation process.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Article
Biochemistry & Molecular Biology
Marina G. Yefimova, Emile Bere, Anne Cantereau-Becq, Annie-Claire Meunier-Balandre, Bruno Merceron, Agnes Burel, Karine Merienne, Celia Ravel, Frederic Becq, Nicolas Bourmeyster
Summary: The study focused on the ultrastructure of the pathological retina in HD R6/1 mice and discovered the presence of myelinosomes, abnormal organelles enriched with mutant Huntingtin protein, which may contribute to the spread of HD in the retina. Exploring the presence of myelinosomes in ocular fluids could potentially serve as an additional biomarker for HD diagnostics.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Andrology
Anne-Sophie Neyroud, Regina Chiechio, Marina Yefimova, Maria Jose Lo Faro, Nathalie Dejucq-Rainsford, Sylvie Jaillard, Pascale Even-Hernandez, Valerie Marchi, Celia Ravel
Summary: Extracellular Vesicles (EVs) are membrane-limited particles secreted by healthy and cancerous cells, containing proteins, lipids, metabolites and nucleic acids, mediating various biological functions. In the male genital tract, three subtypes of EV have been described, differing in secretion location such as the testis, prostate or epididymis. EVs can fuse together, deliver information to recipient cells like spermatozoa, and potentially modulate transmitted information to the next generation through epigenetic changes.
BASIC AND CLINICAL ANDROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Debbie Montjean, Anne-Sophie Neyroud, Marina G. Yefimova, Moncef Benkhalifa, Rosalie Cabry, Celia Ravel
Summary: EDCs can influence gene expression through epigenetic alterations, leading to transgenerational inheritance of traits. Mechanisms such as DNA methylation, acetylation, histone modification, RNA-mediated effects, and extracellular vesicle effects have been implicated. While limited effects on sperm epigenetics have been described, there has been growing interest in this issue in recent years.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Urology & Nephrology
C. Richard, M. Pourchasse, L. Freton, M. Esvan, C. Ravel, B. Peyronnet, R. Mathieu, S. Chhor
Summary: This research explores women's perceptions of male contraception and finds that the majority of women support men taking responsibility for contraception. However, the proportion decreases after women are informed about existing and developing male contraceptives. The most acceptable method for women is the male pill, but there is a lack of knowledge about male contraception.
PROGRES EN UROLOGIE
(2022)
Article
Obstetrics & Gynecology
L. Bujan, N. Nouri, A. Papaxanthos-Roche, B. Ducrocq, F. Brugnon, C. Ravel, N. Rives, M. Teletin, V Drouineaud, B. Delepine, I Berthaut, C. Metzler-Guillemain, A. Devaux, C. Frapsauce, E. Thibault, O. Blagosklonov, M. A. Clarotti, C. Diligent, V Loup Cabaniols, P. Fauque, M. Benchaib, F. Eustache, M. Daudin
Summary: There are moderate differences between non-parent and parent candidates in terms of motivations for gamete donation and personality characteristics.
HUMAN REPRODUCTION OPEN
(2022)
Meeting Abstract
Obstetrics & Gynecology
A. S. Neyroud, A. Rolland, B. Evrard, N. Alary, N. Dejucq-Rainsford, B. Jegou, L. Bujan, C. Ravel, F. Chalmel
HUMAN REPRODUCTION
(2021)
Review
Medicine, Research & Experimental
Yefimova Marina, Celia Ravel, Neyroud Anne-Sophie, Emile Bere, Nicolas Bourmeyster
M S-MEDECINE SCIENCES
(2020)
Article
Obstetrics & Gynecology
A-S Neyroud, M. Roche, M. Domin, S. Jaillard, C. Ravel
GYNECOLOGIE OBSTETRIQUE FERTILITE & SENOLOGIE
(2020)
Article
Geriatrics & Gerontology
Sylvie Jaillard, Katrina Bell, Linda Akloul, Kelly Walton, Kenneth McElreavy, William A. Stocker, Marion Beaumont, Craig Harrisson, Tiina Jaaskelainen, Jorma J. Palvimo, Gorjana Robevska, Erika Launay, Anne-Pascale Satie, Nurin Listyasari, Claude Bendavid, Rajini Sreenivasan, Solene Duros, Jocelyn van den Bergen, Catherine Henry, Mathilde Domin-Bernhard, Laurence Cornevin, Nathalie Dejucq-Rainsford, Marc-Antoine Belaud-Rotureau, Sylvie Odent, Katie L. Ayers, Celia Ravel, Elena J. Tucker, Andrew H. Sinclair
