Review
Biochemistry & Molecular Biology
Fabrice Jardin
Summary: The tumor cells in classical Hodgkin lymphoma (cHL) have unique features, such as their rarity compared to the reactive microenvironment, the loss of B-cell phenotype markers, immune escape capacity, and activation of key biological pathways. Targeting these pathways remains a challenging but potentially impactful therapeutic strategy.
Article
Biochemistry & Molecular Biology
Shihong Zheng, Peichang Cao, Zequn Yin, Xuerui Wang, Yuanli Chen, Maoyun Yu, Baocai Xu, Chenzhong Liao, Yajun Duan, Shuang Zhang, Jihong Han, Xiaoxiao Yang
Summary: Apigenin can improve cholestasis induced by DDC by reducing inflammation and oxidative damage, and improving bile acid metabolism, indicating its potential application for cholestasis treatment.
Article
Biochemistry & Molecular Biology
Zhuoqun Meng, Beiwei Zhu, Min Gao, Guang Wang, Hongjiang Zhou, Jing Lu, Shuang Guan
Summary: Apigenin can alleviate palmitic acid-induced pyroptosis by activating autophagy and regulating the NLRP3 inflammasome, providing a new idea and target for alleviating liver injury.
Article
Food Science & Technology
Jiangqiong Yu, Qingqing Jiang, Ning Liu, Daming Fan, Mingfu Wang, Yueliang Zhao
Summary: Exposure to acrolein, an environmental and dietary pollutant, aggravates inflammation in Human umbilical vein endothelial cells (HUVEC). This aggravation is caused by induction of oxidative stress, activation of the NLRP3 inflammasome and HMGB1/MYD88/NF-xB signaling pathway. Apigenin and apigenin-7, 4'-O-dioctanoate can attenuate acrolein-enhanced inflammation by targeting these signaling pathways.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Horticulture
Kazuo Ichimura, Tomoko Niki, Masami Matoh, Masayoshi Nakayama
Summary: Research found that anthocyanin accumulation in snapdragon petals is suppressed at high temperatures under low light intensity, accompanied by decreased transcript levels of anthocyanin biosynthetic genes. The study also revealed that sugar content may play a role in this process.
SCIENTIA HORTICULTURAE
(2021)
Review
Food Science & Technology
Zhuoxi Li, Jinfeng Zhou, Lianru Ji, Yingye Liang, Shaoqu Xie
Summary: Natural drug research is an important area of focus for the discovery and development of new drugs. This paper reviews the pharmacological effects of apigenin, a naturally occurring flavonoid, including its anti-inflammatory, anti-tumor, anti-oxidation, anti-radiation, antidepressant, cardiovascular protective, glucose and lipid metabolism regulating, kidney protecting, neuroprotective, and antibacterial properties. The paper also discusses the interaction between apigenin and drugs, and summarizes the pharmacological actions of apigenin derivatives and complexes. This research provides valuable insights for the rational development and utilization of apigenin.
FOOD REVIEWS INTERNATIONAL
(2023)
Article
Chemistry, Multidisciplinary
Daniel K. Isika, Fatma Nur Ozkomec, Mustafa Cesme, Omowunmi A. Sadik
Summary: This study reports the synthesis and characterization of a novel class of flavonoid acetamide derivatives which improve the bioavailability and ADMET toxicity properties of flavonoids while decreasing their antioxidant activity.
Article
Engineering, Chemical
Rui Wang, Nan Ni, Qi-xian Zhang, Xu-lin Duan, Qiang He, Yuan-long Chi
Summary: Flavonoid aglycones and flavonol aglycones, such as apigenin and kaempferol, were successfully separated using a Zr(IV) immobilized collagen fiber (ZCF). The adsorption capacity of ZCF for kaempferol was higher than apigenin, and efficient separation of flavonol aglycones from flavonoid aglycones was achieved through ZCF column chromatography.
SEPARATION AND PURIFICATION TECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Mayada Mohamed Mabrouk Zayed, Heba A. Sahyon, Nemany A. N. Hanafy, Maged A. El-Kemary
Summary: This study successfully loaded Apigenin into chitosan and coated it with albumin-folic acid, improving its solubility and stability. In vitro experiments demonstrated the significant anticancer activity of Ap-CH-BSA-FANPs and its potential in treating HCC through inducing apoptosis and enhancing antioxidant activity.
Review
Biochemistry & Molecular Biology
Jung Yoon Jang, Bokyung Sung, Nam Deuk Kim
Summary: Apigenin, a widely distributed flavonoid, has been extensively studied for its physiological effects, including anti-allergic, antibacterial, antidiabetic, anti-inflammatory, antioxidant, antiviral, and blood-pressure-lowering properties. Its anticancer properties are attributed to apoptosis, autophagy, necroptosis, and ferroptosis. This review aims to discuss the therapeutic potential of apigenin as a chemopreventive agent and the roles of programmed cell death mechanisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Food Science & Technology
Shaofeng Xiong, Shumin Yu, Kun Wang, Xiaowei Xiong, Min Xia, Guohua Zeng, Qiren Huang
Summary: In this study, the effects of AP on glycolipid metabolism, browning, and autophagy were investigated using a mouse obesity model and a preadipocyte induction model in vitro. The results showed that AP treatment alleviated body weight, glycolipid metabolic disorder, and insulin resistance through autophagy inhibition and promotion of fat-browning. These findings suggest that autophagy inhibition promotes browning of white adipocytes and highlight the potential of AP in preventing and treating obesity and associated metabolic disorders.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Sapna Mayuri Borah, Lakhon Kma, Muskan Sonam Darjee, Dikshit Deka, Anisha Lyngdoh, Rajesh N. Sharan, Taranga Jyoti Baruah
Summary: In this study, we found that apigenin can bind with WWP2 protein, promote PTEN protein levels, and induce apoptotic activity in non-small cell lung cancer cells.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Cell Biology
Chun Shi, Changhong Ma, Chunmei Ren, Na Li, Xiaotong Liu, Yahan Zhang, Yulong Wang, Xiaodong Li, Peng Lv, Chuanchun Han, Xiaojie Li
Summary: Apigenin enhances its inhibitory effects on OSCC cells by regulating the degradation of Mcl1 through upregulating LINC00629. KLF10 directly binds to the promoter of LINC00629, facilitating its transcription and contributing to the upregulation of LINC00629 upon apigenin treatment. Therefore, the KLF10-LINC00629-Mcl1 axis plays an important role in the anticancer effects of apigenin.
Article
Microbiology
Lina Castano-Duque, Matthew D. Lebar, Carol Carter-Wientjes, David Ambrogio, Kanniah Rajasekaran
Summary: This study investigated the effects of three flavonoids on fungal proliferation and aflatoxin production in Aspergillus flavus. The results showed that the concentrations of apigenin and luteolin modulated fungal proliferation and aflatoxin production in a dose-dependent manner. Microscopy studies revealed disruptions in the mycelial cell wall and localization of flavonoids in sphere-like structures on the mycelia surface. Low concentrations of flavonoids also lowered the total antioxidant capacity in the environment. These findings suggest that flavonoids may disrupt cell wall integrity and act as potential signaling molecules, leading to reduction of fungal proliferation and aflatoxin production.
Review
Pharmacology & Pharmacy
Xiaozhen Ji, Kai Liu, Qingyue Li, Qun Shen, Fangxuan Han, Qingmei Ye, Caijuan Zheng
Summary: This review examines the progress of apigenin and genistein, two isomers, in treating prostate cancer over the past decade. Although they target the same signaling pathways in prostate cancer cells, they have different mechanisms of action. Genistein appears to be the more promising option, but further validation is needed through clinical trials.
FRONTIERS IN PHARMACOLOGY
(2022)
