Journal
FERTILITY AND STERILITY
Volume 96, Issue 5, Pages 1170-1174Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.fertnstert.2011.08.028
Keywords
Primary ovarian insufficiency; FMR1; CGG repeat; premutation allele
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Funding
- Ministry of Health, Labor, and Welfare of Japan [H22-126]
- Ministry of Education, Culture, Sports, Science, and Technology of Japan [21592116]
- Grants-in-Aid for Scientific Research [21592116, 22227002] Funding Source: KAKEN
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Objective: To define the number of CGG repeats in the FMR1 gene of Japanese patients with primary ovarian insufficiency (POI) and normal controls. Design: Retrospective, controlled cohort study. Setting: Outpatient department of an academic tertiary center. Patient(s): One hundred twenty-eight consecutive Japanese patients with sporadic, nonsyndromic POI and 98 controls with normal menstruation. Intervention(s): Deoxyribonucleic acid was obtained from the plasma of each subject. Main Outcome Measure(s): Differences in the distribution of CGG repeat numbers between patients with POI and controls. Result(s): Six alleles in the intermediate range and two in the premutation range were found in five and two patients with POI, respectively, but none were identified in normal controls. The prevalence of FMR1 premutation among Japanese POI patients was 1.56% (2 of 128). The prevalence of having >36 CGG repeats in the FMR1 gene was significantly higher in patients with POI than in controls, and age at the onset of amenorrhea was significantly lower in patients with >38 repeats. Conclusion(s): More than 36 CGG repeats in the FMR1 might intensify the etiology of POI, at least up to the premutation range. (Fertil Steril (R) 2011; 96: 1170-4. (C) 2011 by American Society for Reproductive Medicine.)
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