Article
Medicine, General & Internal
Hideto Yamada, Masashi Deguchi, Shigeru Saito, Toshiyuki Takeshita, Mari Mitsui, Tsuyoshi Saito, Takeshi Nagamatsu, Koichi Takakuwa, Mikiya Nakatsuka, Satoshi Yoneda, Katsuko Egashira, Masahito Tachibana, Keiichi Matsubara, Ritsuo Honda, Atsushi Fukui, Kanji Tanaka, Kazuo Sengoku, Toshiaki Endo, Hiroaki Yata
Summary: This study investigated whether treatment with a high dose of intravenous immunoglobulin (IVIG) in early pregnancy can improve pregnancy outcomes in women with unexplained recurrent pregnancy loss (RPL). The results showed that IVIG treatment significantly increased the ongoing pregnancy rate and live birth rate in women with unexplained RPL, suggesting that IVIG may be an effective treatment option for this condition.
Article
Immunology
Hideto Yamada, Masashi Deguchi, Shigeru Saito, Toshiyuki Takeshita, Mari Mitsui, Tsuyoshi Saito, Takeshi Nagamatsu, Koichi Takakuwa, Mikiya Nakatsuka, Satoshi Yoneda, Katsuko Egashira, Masahito Tachibana, Keiichi Matsubara, Ritsuo Honda, Atsushi Fukui, Kanji Tanaka, Kazuo Sengoku, Toshiaki Endo, Hiroaki Yata
Summary: The study aimed to evaluate the involvement of natural killer (NK) cells and regulatory T (Treg) cells in the beneficial effects of high dose intravenous immunoglobulin (IVIG) on recurrent pregnancy losses (RPL) of unexplained etiology. The results showed that IVIG increased Treg cell percentages and suppressed NK cell activity very early in pregnancy, and these changes were associated with subsequent live birth. Stimulation of Treg cells and suppression of NK cell activity may be a mechanism of the pharmacological effects of high dose IVIG.
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2023)
Article
Obstetrics & Gynecology
Haley G. Genovese, Dana B. Mcqueen
Summary: This manuscript reports on the prevalence of early pregnancy loss and discusses the impact of improved pregnancy diagnosis, as well as the influence of increased age and body mass index at first birth.
FERTILITY AND STERILITY
(2023)
Article
Immunology
Xi Chen, Lu Gao, Zhen Zhen, Ying Wang, Jia Na, Wen Yu, Xinyuan Chu, Yue Yuan, Suyun Qian
Summary: The purpose of this study was to explore the risk factors and develop predictive models for intravenous immunoglobulin (IVIG) resistance in children with recurrent KD. The study found that age and IVIG resistance at the first episode, as well as some laboratory variables, may be risk factors for IVIG resistance. Two predictive models for IVIG resistance with excellent performance were established.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Medicine, General & Internal
Pia Egerup, Henriette Svarre Nielsen, Anders Nyboe Andersen, Ole Bjarne Christiansen
Summary: Pregnancy loss after IVF is as common as after spontaneous conception, and recurrent pregnancy loss may have an immunological background. This study investigated the effect of immunotherapy on women with RPL after IVF. The results showed that immunotherapy led to a higher live birth rate of 34%. This study indicates that immunotherapy may be a promising intervention for women with RPL after IVF.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Obstetrics & Gynecology
Pedro Melo, Rima Dhillon-Smith, Md Asiful Islam, Adam Devall, Arri Coomarasamy
Summary: Approximately 80% of miscarriages occur within the first 12 weeks of gestation, with more than half resulting from genetic defects. Recent use of big data has led to the discovery of specific gene mutations that may be implicated in sporadic and recurrent miscarriages.
FERTILITY AND STERILITY
(2023)
Article
Immunology
Shorooq Banjar, Einav Kadour, Rabea Khoudja, Shaonie Ton-leclerc, Coralie Beauchamp, Marc Beltempo, Michael H. Dahan, Phil Gold, Isaac Jacques Kadoch, Wael Jamal, Carl Laskin, Neal Mahutte, Shauna Leigh Reinblatt, Camille Sylvestre, William Buckett, Genevieve Genest
Summary: Recurrent pregnancy loss (RPL) affects a significant percentage of couples attempting to conceive. Immune-mediated RPL may be suspected, and treatments like intravenous immunoglobulin (IVIg) have been used but remain controversial. This study evaluated the outcomes of IVIg use in RPL and developed a framework for its use.
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2023)
Article
Obstetrics & Gynecology
Jade E. Bilardi, Meredith Temple-Smith
Summary: Miscarriage and recurrent miscarriage have profound and prolonged psychological impacts, yet support for miscarriage remains inadequate. Acknowledgment and validation of grief, provision of information, and addressing the discrepancy between bereavement care offered and desired are important steps to ameliorate the impact. Collecting national miscarriage data and establishing national research funding priorities would allow for a better understanding of the socioeconomic cost and burden of miscarriage and enable targeted research for public health benefit.
FERTILITY AND STERILITY
(2023)
Review
Medicine, General & Internal
Akbayan Turesheva, Gulzhanat Aimagambetova, Talshyn Ukybassova, Aizada Marat, Perizat Kanabekova, Lyazzat Kaldygulova, Ainur Amanzholkyzy, Svetlana Ryzhkova, Anastassiya Nogay, Zaituna Khamidullina, Aktoty Ilmaliyeva, Wassim Y. Almawi, Kuralay Atageldiyeva
Summary: Recurrent pregnancy loss is a complex health challenge with no universally accepted definition. The true incidence is difficult to estimate due to inconsistency in definitions and criteria applied by international guidelines. The exact etiology remains questionable and up to 75% of cases are unexplained. This review aimed to summarize accumulated knowledge on etiology, risk factors, diagnostic options, and management approach to recurrent pregnancy loss.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Environmental Sciences
Yingying Zhang, Xi Yan, Jianhua Tan, Jifan Tan, Chunsheng Liu, Pan Yang, Yanping Xian, Qiong Wang
Summary: Exposure to heavy metals can have toxic effects on female reproduction and embryo development. This study found that calcium and selenium exposure were negatively associated with miscarriage, while lead exposure was positively associated with miscarriage. Additionally, the correlations among exposures to different metals differed slightly between the control group and the uRM group.
Review
Immunology
Wael Saab, Srividya Seshadri, Changsheng Huang, Lujain Alsubki, Nayoung Sung, Joanne Kwak-Kim
Summary: In recent years, advancements in reproductive technologies and genetic testing have led to improved embryo quality and higher pregnancy rates. However, some patients still face challenges with recurrent implantation failures and recurrent pregnancy losses, which could be attributed to immune dysregulations. Maintaining an anti-inflammatory environment before conception may yield superior results, and intravenous immunoglobulin G treatment has been shown to enhance reproductive outcomes in patients with immune dysregulations leading to RIFs and RPLs.
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2021)
Article
Clinical Neurology
Xue Gong, Rong Luo, Jie Liu, Kundian Guo, Aiqing Li, Xu Liu, Yue Liu, Dong Zhou, Zhen Hong
Summary: This study compared the effectiveness and safety of different treatment strategies as initial therapy for anti-NMDAR encephalitis. The results showed that combined treatment with IVIg and IVMP had a higher response rate, improved Rankin Scale scores, and lower recurrence rate compared to either IVIg or IVMP monotherapy.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Medicine, General & Internal
Anne-Sophie Braun, Kilian Vomstein, Elisabeth Reiser, Susanne Tollinger, Christiana Kyvelidou, Katharina Feil, Bettina Toth
Summary: RPL and RIF are challenges in reproductive medicine. The immune system plays a pivotal role in endometrial receptivity, successful implantation, and pregnancy complications. Understanding immune dysregulation especially in NK and T cell subtypes may lead to better diagnostic concepts and treatments. Tailored immunotherapy based on endometrial immunophenotyping might be an option for RPL and RIF patients, but further research is needed.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Shijian Lv, Mei Liu, Lizhen Xu, Cong Zhang
Summary: This study reveals that downregulation of SKP2 in patients with recurrent miscarriage leads to impaired decidualization, making individuals more susceptible to recurrent miscarriage.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2021)
Article
Immunology
Jiayu Wang, Jinli Ding, Sainan Zhang, Xin Chen, Sisi Yan, Yan Zhang, Tailang Yin
Summary: USP2a plays a crucial role in regulating trophoblast invasion and abnormal expression of USP2a may contribute to recurrent miscarriage by affecting trophoblast invasion. Interestingly, TGF-beta secreted by M2 macrophages can induce trophoblast migration and invasion, highlighting the complex interplay of various factors in the pathogenesis of RM.
FRONTIERS IN IMMUNOLOGY
(2021)
