Article
Pediatrics
Paul Wiegandt, Thomas Jack, Alexander von Gise, Kathrin Seidemann, Martin Boehne, Harald Koeditz, Philipp Beerbaum, Michael Sasse, Torsten Kaussen
Summary: The survey reveals inconsistent acceptance of definitions and guidelines among pediatric intensivists in Germany regarding IAH and ACS. The awareness and knowledge of valid definitions of ACS have improved, but a significant number of physicians still have not diagnosed IAH/ACS and have never measured intra-abdominal pressure (IAP).
Article
Multidisciplinary Sciences
Rui Antunes Pereira, Andre F. Esteves, Filipe S. Cardoso, Rui Perdigoto, Paulo Marcelino, Faouzi Saliba
Summary: This study aimed to characterize abdominal perfusion pressure (APP) in critically ill cirrhotic patients and analyze the prevalence and risk factors of abdominal hypoperfusion (AhP) and outcomes. The results showed a high prevalence of AhP in critical cirrhotic patients, which was independently associated with higher ACLF grade and baseline paracentesis. Overall, the prevention and treatment of AhP in high-risk cirrhotic patients are crucial.
SCIENTIFIC REPORTS
(2023)
Article
Medicine, General & Internal
Andrea C. Marin, Sharon Hechter, Ankita Prasad, Dina Alnabwani, Charles Lwoodsky, Pramil Cheriyath
Summary: Normal intra-abdominal pressure ranges from 0 to 5 mmHg, but abdominal compartment syndrome (ACS) occurs when the sustained pressure exceeds 20 mmHg, leading to organ dysfunction. ACS primarily affects critically ill patients and can result from various conditions or injuries in the abdomen or pelvic area. If not promptly recognized, ACS can lead to severe complications and high mortality rates.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2023)
Article
Multidisciplinary Sciences
Rui Pereira, Maria Buglevski, Rui Perdigoto, Paulo Marcelino, Faouzi Saliba, Stijn Blot, Joel Starkopf
Summary: This study found a high prevalence of intra-abdominal hypertension and abdominal compartment syndrome in critically ill cirrhotic patients, with risk factors such as alcoholic cirrhosis and infection. Early diagnosis and treatment of these conditions may improve outcomes.
Article
Endocrinology & Metabolism
Ali Abbara, Bijal Patel, Isha Parekh, Akanksha Garg, Channa N. N. Jayasena, Alexander N. N. Comninos, Waljit S. Dhillo
Summary: This study aimed to assess the rate of Ovarian Hyperstimulation Syndrome (OHSS) requiring ICU admission between 1996-2020 and found that the rate has decreased with the introduction of safer IVF practices.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Yi Wen, Wen-qing Zhuo, Hong -yin Liang, Zhu Huang, Long Cheng, Fu-zhou Tian, Tao Wang, Li -jun Tang, Zhu-lin Luo
Summary: In patients with severe acute pancreatitis (SAP) complicated with intra-abdominal hypertension (IAH), the application of abdominal paracentesis drainage (APD) can effectively attenuate inflammation injury, avoid further interventions, and reduce multiple organ failure.
AMERICAN JOURNAL OF THE MEDICAL SCIENCES
(2023)
Review
Endocrinology & Metabolism
Bhavna Sharma, Kanyada Koysombat, Alexander N. Comninos, Waljit S. Dhillo, Ali Abbara
Summary: Infertility is a global health issue causing psychological distress. In vitro fertilisation (IVF) involves stimulating ovaries with hormones to retrieve multiple eggs. Excessive stimulation can lead to complications like OHSS and multiple pregnancies. The choice of trigger for egg maturation can affect IVF efficacy and safety. Kisspeptin, a regulator of the HPG axis, is being explored as a potential trigger for egg maturation.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Genetics & Heredity
Diane M. Tober, Kevin Richter, Dougie Zubizarreta, Said Daneshmand
Summary: This study aimed to evaluate self-reported survey data from US oocyte donors on their experiences with ovarian hyperstimulation syndrome (OHSS) and investigate possible correlations between OHSS severity and number of oocytes retrieved, trigger type, and prior OHSS history. An 85-question retrospective survey was conducted online, and the results showed that donors who received GnRH agonist triggers reported milder OHSS compared to those who received hCG or dual triggers. Among donors undergoing multiple retrieval cycles, the severity of OHSS in the second cycle was strongly associated with the severity in the first cycle.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2023)
Article
Endocrinology & Metabolism
Kai Huang, Ying Shi, Gezi Chen, Hao Shi, Jun Zhai
Summary: This study evaluated potential predictors for recovery time in pregnant patients with moderate to severe ovarian hyperstimulation syndrome (OHSS). The results showed that polycystic ovary syndrome (PCOS) and hypoalbuminemia were associated with a significantly longer recovery time. Meanwhile, high levels of hemoglobin, platelets, and fibrinogen (Fib) were also related to longer recovery time.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Abraham Fessehaye, Wondimu Gudu
Summary: A 32-year-old primigravida Ethiopian woman developed ovarian hyperstimulation syndrome at 15 weeks gestation following in vitro fertilization, highlighting the importance of frequent follow-up to detect early signs and prevent complications. Early recognition and management can avoid the need for intensive care unit care.
JOURNAL OF MEDICAL CASE REPORTS
(2021)
Review
Endocrinology & Metabolism
Di Wu, Hao Shi, Yiping Yu, Ting Yu, Jun Zhai
Summary: Calcium, hydroxyethyl starch (HES), and cabergoline can effectively and safely prevent moderate-to-severe OHSS, with calcium being the most effective intervention.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Nikoleta Papanikolaou, Ophelia Millar, Amy Coulden, Nina Parker, Lee Sit, Chris Kelly, Jeremy Cox, Waljit S. Dhillo, Karim Meeran, Maya Al Memar, Richard Anderson, D. Aled Rees, Niki Karavitaki, Channa N. Jayasena
Summary: This study aims to increase awareness and improve diagnosis and management of women with FGA-induced OHSS by presenting the clinical course of FGA-induced OHSS cases identified by some of the largest UK pituitary endocrine tertiary centers. The results show that FGA is a rare cause of spontaneous OHSS and TSS can improve clinical and biochemical features of ovarian hyperstimulation in FGA. Improved awareness of FGA will prevent inappropriate emergency ovarian surgery.
CLINICAL ENDOCRINOLOGY
(2023)
Article
Obstetrics & Gynecology
Ginevra Mills, Michael H. Dahan
Summary: In the study, the use of GnRH antagonists in GnRH agonist cycles was found to reduce the risk of developing moderate and severe OHSS by promoting luteolysis and downregulating VEGF production and receptor response, thereby decreasing vascular permeability.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2022)
Article
Reproductive Biology
Fukiko Kasuga-Yamashita, Tsuyoshi Baba, Sachiko Nagao, Yuya Fujibe, Miyuki Morishita, Yoshika Kuno, Tasuku Mariya, Hiroyuki Honnma, Toshiaki Endo, Tamotsu Kiya, Tsuyoshi Saito
Summary: The study found that Letrozole may promote follicle development by increasing FSHR expression, potentially offering fertility preservation benefits for patients with estrogen-dependent cancers. Further research is needed to investigate Letrozole's direct impact on reducing OHSS.
JOURNAL OF OVARIAN RESEARCH
(2022)
Article
Pediatrics
Raluca-Alina Mocanu, Catalin Cirstoveanu, Mihaela Bizubac, Ionut Fernando Secheli, Nicolae Sebastian Ionescu
Summary: The main goal of surgical treatment for gastroschisis and omphalocele is to reduce the viscera in the abdominal cavity and close the abdomen without increasing intraabdominal pressure. A retrospective study was conducted on patients admitted for these conditions, and the presence of postoperative abdominal compartment syndrome was highlighted. Based on the results, the measurement of intraabdominal pressure was implemented to prevent the development of abdominal compartment syndrome during closure.
Editorial Material
Obstetrics & Gynecology
James H. Segars, Maya Diab
FERTILITY AND STERILITY
(2021)
Article
Obstetrics & Gynecology
Edwina H. Yeung, Pauline Mendola, Rajeshwari Sundaram, Xuehuo Zeng, Weihua Guan, Michael Y. Tsai, Sonia L. Robinson, Judy E. Stern, Akhgar Ghassabian, David Lawrence, Thomas G. O'Connor, James Segars, Robert E. Gore-Langton, Erin M. Bell
Summary: The study found that assisted reproductive technologies (ART) were associated with differences in DNA methylation levels at birth compared to children conceived without fertility treatment, but only one difference at an imprinting region appeared to persist in childhood.
FERTILITY AND STERILITY
(2021)
Editorial Material
Obstetrics & Gynecology
James Segars, Michael A. Thomas
FERTILITY AND STERILITY
(2021)
Editorial Material
Obstetrics & Gynecology
Md Soriful Islam, Most Mauluda Akhtar, James H. Segars
FERTILITY AND STERILITY
(2021)
Editorial Material
Obstetrics & Gynecology
Md Soriful Islam, Most Mauluda Akhtar, James H. Segars
Summary: Activin A plays a role in inducing a fibrotic phenotype in uterine fibroid cells by increasing ECM protein expression through activation of Smad 2/3 and p38 MAPK signaling pathways.
FERTILITY AND STERILITY
(2021)
Article
Obstetrics & Gynecology
Bhuchitra Singh, Holly Sims, Irene Trueheart, Khara Simpson, Karen C. Wang, Kristin Patzkowsky, Thomas Wegman, Jean-Marie Soma, Rosina Dixon, Friederike Jayes, Kristin Voegltine, Gayane Yenokyan, Szu-Chi Su, Phyllis Leppert, James H. Segars
Summary: The study aimed to evaluate the safety and tolerability of collagenase injection directly into uterine fibroids. The results showed no significant adverse events following collagenase injection, and a reduction in collagen content by 39% and density by 21% in treated samples. Subjects reported a decrease in fibroid-related pain post-injection, supporting further clinical investigation of collagenase as a minimally invasive treatment for uterine fibroids.
REPRODUCTIVE SCIENCES
(2021)
Article
Multidisciplinary Sciences
Nicholas W. Bateman, Christopher M. Tarney, Tamara Abulez, Anthony R. Soltis, Ming Zhou, Kelly Conrads, Tracy Litzi, Julie Oliver, Brian Hood, Paul Driggers, Coralie Viollet, Clifton Dalgard, Matthew Wilkerson, William Catherino, Chad A. Hamilton, Kathleen M. Darcy, Yovanni Casablanca, Ayman Al-Hendy, James Segars, Thomas P. Conrads, G. Larry Maxwell
Summary: Pathogenic mutations in fumarate hydratase (FH) drive hereditary leiomyomatosis and renal cell cancer (HLRCC) and increase the risk of developing uterine leiomyomas (ULMs). An integrated proteogenomic analysis of ULMs from HLRCC and non-syndromic patients identified a significantly higher protein:transcript correlation in HLRCC, along with co-altered proteins and transcripts related to oxidative stress response and cellular metabolism signaling. The study also confirmed and defined novel proteogenomic alterations in uterine leiomyoma tissues collected from HLRCC patients, emphasizing conserved molecular alterations correlating with inactivation of the FH tumor suppressor gene.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Nicholas W. Bateman, Christopher M. Tarney, Tamara S. Abulez, Brian L. Hood, Kelly A. Conrads, Ming Zhou, Anthony R. Soltis, Pang-Ning Teng, Amanda Jackson, Chunqiao Tian, Clifton L. Dalgard, Matthew D. Wilkerson, Michael D. Kessler, Zachary Goecker, Jeremy Loffredo, Craig D. Shriver, Hai Hu, Michele Cote, Glendon J. Parker, James Segars, Ayman Al-Hendy, John Risinger, Neil T. Phippen, Yovanni Casablanca, Kathleen M. Darcy, G. Larry Maxwell, Thomas P. Conrads, Timothy D. O'Connor
Summary: Characterization of ancestry-linked peptide variants in disease-relevant patient tissues is important for understanding the relationship between patient ancestry and disease pathogenesis. The study identifies peptide ancestry informative markers (pAIMs) to determine ancestry proportions and their correlation with patient race and genotype. The findings contribute to the understanding of the impact of ancestry on the human proteome and its relevance to uterine neoplasms.
Review
Obstetrics & Gynecology
Abigail Combs, Bhuchitra Singh, Elisabeth Nylander, Md Soriful Islam, Ha Vi Nguyen, Elissa Parra, Ameerah Bello, James Segars
Summary: Vitamin D has emerged as a potential therapy for uterine fibroids based on experimental and clinical evidence. It has been found to decrease proliferation and Wnt/beta-catenin signaling in fibroid cells, and studies have shown its effectiveness in prevention and treatment of fibroids.
REPRODUCTIVE SCIENCES
(2023)
Article
Medicine, General & Internal
Hugh Taylor, Howard J. Li, Sandra Carson, Valerie Flores, Lubna Pal, Jared Robbins, Nanette F. Santoro, James H. Segars, David Seifer, Hao Huang, Steven Young, Heping Zhang
Summary: This is a prospective study on the efficacy of GnRH antagonist pretreatment for women with endometriosis undergoing IVF. The study aims to recruit 814 patients who will be randomly assigned to receive either GnRH antagonist or placebo treatment for 8 weeks before undergoing IVF. The primary outcome is live birth, and secondary outcomes include oocyte number, fertilisation rate, embryo morphology, implantation rates, and endometriosis-related obstetrical outcomes.
Article
Obstetrics & Gynecology
Kathleen E. O'Neill, Jacqueline Y. Maher, Monica M. Laronda, Francesca E. Duncan, Richard D. LeDuc, Marla E. Lujan, Kutluk H. Oktay, Alison M. Pouch, James H. Segars, Elizabeth L. Tsui, Mary B. Zelinski, Lisa M. Halvorson, Veronica Gomez-Lobo
Summary: This article introduces the conceptualization process and outcomes of an effort to standardize ovarian nomenclature and define the organ's features. The goal was to develop a spatially defined and semantically consistent terminology of the ovary to support collaborative, team science-based endeavors aimed at generating reference atlases of the human ovary. The new systems of nomenclature and mapping will better reflect the ovary's heterogeneous composition and function, support the standardization of tissue collection, facilitate functional analyses, and enable clinical and research collaborations.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Review
Obstetrics & Gynecology
Joshua M. Morris, Angela Liang, Katarina Fleckenstein, Bhuchitra Singh, James Segars
Summary: This systematic review analyzed the effectiveness of minimally invasive approaches to treat fibroids and compared their impact on quality of life and symptoms. The results showed that radiofrequency ablation and ultrasound-guided sclerotherapy significantly improved quality of life, while uterine artery embolization and ultrasound-guided high-intensity frequency ultrasound had similar effects as surgical interventions. Minimally invasive approaches were effective alternatives to surgery for improving quality of life and fibroid-associated symptoms.
REPRODUCTIVE SCIENCES
(2023)
Article
Obstetrics & Gynecology
Kamaria C. Cayton Vaught, Dana Hazimeh, Ashlie Sewdass Carter, Kate Devine, Jacqueline Y. Maher, Marcy Maguire, Elizabeth A. McGee, Paul H. Driggers, James H. Segars
Summary: This study found that AKAP13 may function as a scaffolding protein in follicle-stimulating hormone (FSH) signal transduction by interacting with CREB, leading to phosphorylation of CREB.
REPRODUCTIVE SCIENCES
(2023)
Article
Obstetrics & Gynecology
Bhuchitra Singh, Julia Berry, Michelle Volovsky, Yanqing Xu, Ahmed M. Soliman, Carol B. Thompson, James H. Segars
Summary: The objective of this study was to evaluate the utility and impact of the Painful Periods Screening Tool (PPST) to improve healthcare delivery for people with symptoms of pelvic pain. The results showed that most participants reported severe pain during menstruation, and using the PPST helped them discuss their symptoms more easily with healthcare providers.
REPRODUCTIVE SCIENCES
(2023)
Article
Nutrition & Dietetics
Hiba Siblini, Ayman Al-Hendy, James Segars, Frank Gonzalez, Hugh S. Taylor, Bhuchitra Singh, Ainna Flaminia, Valerie A. Flores, Gregory M. Christman, Hao Huang, Jeremy J. Johnson, Heping Zhang
Summary: This is an abstract of preliminary results from a clinical study on the use of EGCG for treating unexplained infertility associated with uterine fibroids. The study found that a daily dose of 800 mg of EGCG alone or in combination with clomiphene citrate or letrozole (for 5 days) is well-tolerated and not associated with liver toxicity or folate deficiency in reproductive-aged women.