Journal
FERTILITY AND STERILITY
Volume 94, Issue 6, Pages 2417-2420Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.fertnstert.2010.03.053
Keywords
Granulosa cell; cumulus cell; IGF; IGF receptor; IGF binding protein
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The mRNA expression of insulin-like growth factor (IGF) components was investigated in granulosa cells (GCs) and cumulus cells (CCs) sampled from immature and mature follicles in women with and without polycystic ovary syndrome (PCOS). Gene expression for IGF-binding protein (IGFBP) 3 in GCs definitely differed between normal women and women with PCOS, whereas increase in IGF-I and IGF receptor (IGFR) 2 mRNA in mature-follicle GCs, increase in IGF-II, IGFR-1, and IGFBP-4 mRNA in immature-follicle GCs, increase in IGFR-2 and IGFBP-2 mRNA in mature-follicle CCs, and increase IGFBP-6 mRNA in immature-follicle CCs were observed in both normal women and women with PCOS. (Fertil Steril (R) 2010;94:2417-20. (C)2010 by American Society for Reproductive Medicine.)
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