Article
Immunology
Yue Li, Si-Ting Chen, Yu-Ying He, Bo Li, Chen Yang, Zhen-Shan Yang, Zeng-Ming Yang
Summary: In this study, the involvement of secreted HMGB1 in early mouse pregnancy was investigated. It was found that HMGB1 can be detected in the uterine lumen fluid and its secretion is influenced by the presence of blastocysts. The presence of trypsin in blastocysts and its ability to stimulate HB-EGF production was also demonstrated. Furthermore, the role of PAR2-HMGB1-ADAM17-HB-EGF signaling pathway in decidualization was identified.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Obstetrics & Gynecology
Aikaterini Berdiaki, Sophia Zafeiropoulou, Fanourios Makrygiannakis, Panagiotis Drakopoulos, Timur Gurgan, Antonios Makrigiannakis
Summary: Ageing has an impact on the function and gene expression of endometrial stromal cells, which is important for understanding the causes of infertility.
REPRODUCTIVE BIOMEDICINE ONLINE
(2022)
Article
Oncology
Ann H. Rosendahl, Sofie Bjorner, Maria Ygland Rodstrom, Karin Jirstrom, Signe Borgquist, Christian Ingvar, Michael N. Pollak, Helena Jernstrom
Summary: The study found that circulating levels of IGF-I and IGFBP-3 in breast cancer patients are significantly associated with recurrence-risk, while the correlation with IGFBP-7 levels is weaker. There is a significant interaction between IGFBP-7 levels and recurrence-risk in patients with IGF-IRm positivity.
FRONTIERS IN ONCOLOGY
(2021)
Review
Cell Biology
Vineet K. Maurya, Francesco J. DeMayo, John P. Lydon
Summary: The synchrony between progesterone-driven endometrial receptivity and the arrival of a euploid blastocyst is crucial for successful embryo implantation and establishment of pregnancy. Aberrant progesterone molecular responses can lead to infertility, early embryo miscarriage, gestational complications, and endometrial pathologies. Further identification and functional analysis of key molecular mediators and modifiers of the endometrial response to progesterone may provide insight into early endometrial changes and lead to more effective diagnostics and therapies for female infertility and gynecological morbidities.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Chow-Seng Kong, Alexandra Almansa Ordonez, Sarah Turner, Tina Tremaine, Joanne Muter, Emma S. Lucas, Emma Salisbury, Rita Vassena, Gustavo Tiscornia, Ali A. Fouladi-Nashta, Geraldine Hartshorne, Jan J. Brosens, Paul J. Brighton
Summary: The study found that uterine natural killer cells play a crucial role in embryo biosensing and implantation process, highlighting their importance in selectively eliminating senescent decidual cells.
Article
Medicine, General & Internal
Yun Sun, Linlin Cui, Yao Lu, Jichun Tan, Xi Dong, Tianxiang Ni, Junhao Yan, Yichun Guan, Guimin Hao, Jia-Yin Liu, Bo Zhang, Daimin Wei, Yan Hong, Yaqiong He, Jia Qi, Bing Xu, Juanjuan Lu, Qian Zhang, Shanshan Zhao, Xiaowei Ji, Xiaofang Du, Jie Zhang, Jinyong Liu, Jing Wang, Yingqin Huang, Dongmei Huang, Yanzhi Du, Hugo Vankelecom, Heping Zhang, Zi-jiang Chen
Summary: Prednisone treatment does not improve live birth rate in patients with recurrent implantation failure compared to placebo. The use of prednisone may increase the risk of preterm delivery and biochemical pregnancy loss. These findings challenge the value of prednisone use in clinical practice for the treatment of recurrent implantation failure.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Review
Multidisciplinary Sciences
Mengqi Liu, Yuan Yuan, Yan Qiao, Yuzhu Tang, Xi Sui, Ping Yin, Dongzi Yang
Summary: This meta-analysis examined the effects of immunomodulatory therapies on the clinical pregnancy outcomes of patients with repeated implantation failure. The findings suggest that peripheral blood mononuclear cells, platelet-rich plasma, and subcutaneous granulocyte colony-stimulating factor can significantly improve the clinical pregnancy rate. Platelet-rich plasma also showed superior live birth rate and implantation rate compared to other treatments.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Esayas Tekle, Yemataw Gelaw, Mulat Dagnew, Aschalew Gelaw, Markos Negash, Eyuel Kassa, Segenet Bizuneh, Dessalew Wudineh, Fikir Asrie
Summary: This study assessed the value of basic coagulation parameters and factors associated with disease severity in risk stratification and prognosis among COVID-19 patients. The findings revealed that prolonged prothrombin time (PT) was associated with severe COVID-19 and poorer prognosis.
Article
Endocrinology & Metabolism
Anna Sophie L. Kjaer, Rikke Beck Jensen, Jorgen H. Petersen, Allan Linneberg, Line Lund Karhus, Louise Scheutz Henriksen, Trine Holm Johannsen, Katharina M. Main, Andrew R. Hoffman, Anders Juul
Summary: This study found that the levels of IGF-I and IGFBP-3 remain stable throughout an individual's lifetime, thus a single measurement of IGF-I can reliably reflect lifetime exposure. GH therapy has only a slight effect on lifetime exposure to IGF-I and remains below the average exposure in the reference population.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Cardiac & Cardiovascular Systems
Christos Charalambous, James C. Moon, Jeff M. P. Holly, Nishi Chaturvedi, Alun D. Hughes, Gabriella Captur
Summary: The study found that decreasing levels and bioavailability of IGF-I are associated with prolongation of the QTc interval in older individuals.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cell & Tissue Engineering
Maria Diniz-da-Costa, Chow-Seng Kong, Katherine J. Fishwick, Thomas Rawlings, Paul J. Brighton, Amelia Hawkes, Joshua Odendaal, Siobhan Quenby, Sascha Ott, Emma S. Lucas, Pavle Vrljicak, Jan J. Brosens
Summary: The study identifies a highly proliferative population of mesenchymal cells (hPMC) in midluteal human endometrium, potentially serving as novel decidual precursors; hPMC differ from endometrial stromal cells in the expression of genes for prolactin and other decidual transcription factors, and show signs of differentiation into a decidual subpopulation discovered in early pregnancy; recurrent pregnancy loss is associated with depletion of hPMC.
Article
Endocrinology & Metabolism
Zhihong Niu, Mingjuan Zhou, Lan Xia, Shen Zhao, Aijun Zhang
Summary: This study aimed to investigate the effects of LMWH on uterine inflammatory cytokine profiles and pregnancy outcomes in patients with repeated implantation failure (RIF) but without thrombophilia. The results showed that uterine cytokine profiles after LMWH administration were associated with pregnancy outcomes, suggesting that LMWH may be beneficial for patients with three implantation failures who do not have coagulation disorders.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Cell Biology
Yi Yang, Qiu-Yang Zhu, Ji-Long Liu
Summary: This study utilized single-cell RNA sequencing to investigate uterine receptivity in mice, revealing 19 distinct cell clusters and identifying global gene expression changes associated with uterine receptivity in each cell type. The data provide a valuable resource for understanding the molecular mechanisms underlying uterine receptivity.
CELL PROLIFERATION
(2021)
Article
Endocrinology & Metabolism
Emmie N. Upners, Marie Lindhardt Ljubicic, Alexander S. Busch, Margit Bistrup Fischer, Kristian Almstrup, Jorgen H. Petersen, Rikke Beck Jensen, Casper P. Hagen, Anders Juul
Summary: This study evaluated the rapid changes in weight and length, as well as the determinants, in healthy infants and established reference curves for IGF-I and IGFBP-3 in children aged 0 to 1 years. The findings showed a significant association between IGF-I and infant weight gain in girls, but not with longitudinal growth.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Charlott Hoerenz, Mandy Vogel, Kerstin Wirkner, Uta Ceglarek, Joachim Thiery, Roland Pfaeffle, Wieland Kiess, Juergen Kratzsch
Summary: This study examines the effects of BMI, contraceptive drugs, and hormone replacement therapy on serum levels of IGF-I and IGFBP-3. The results indicate that obesity and contraceptive drugs can influence the levels of IGF-I and IGFBP-3 in different age groups.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)