Journal
FERTILITY AND STERILITY
Volume 93, Issue 7, Pages 2418-2420Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.fertnstert.2009.08.036
Keywords
GnRH antagonist; GnRH agonist triggering; OHSS; oocyte donation
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In this prospective, follow-up study of 102 high-risk oocyte donors in their luteal phase, we found a complete absence of ovarian hyperstimulation syndrome (no signs of hemoconcentration or ascites) after the donors were triggered with a gonadotropin releasing-hormone (GnRH) agonist. Due to its powerful preventive effect, the GnRH antagonist protocol combined with a GnRH agonist trigger should preferentially be used in egg donors; in conjunction with an effective luteal support or embryo cryopreservation, the protocol could also be applied to high-risk in vitro fertilization patients. (Fertil Steril (R) 2010;93:2418-20. (C) 2010 by American Society for Reproductive Medicine.)
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