Article
Medicine, General & Internal
Yunliao Luo, Huajuan Shen, Hongjing Li, Zongjian Tan, Chaojun Chen, Weiming Chen, Jun He
Summary: This article reports a rare case of ovarian hyperstimulation syndrome (OHSS) combined with ruptured corpus luteum during twin pregnancy. Through dynamic ultrasound monitoring and observation of vital signs, surgical exploration was avoided and the twin pregnancy was successfully preserved.
Article
Genetics & Heredity
Diane M. Tober, Kevin Richter, Dougie Zubizarreta, Said Daneshmand
Summary: This study aimed to evaluate self-reported survey data from US oocyte donors on their experiences with ovarian hyperstimulation syndrome (OHSS) and investigate possible correlations between OHSS severity and number of oocytes retrieved, trigger type, and prior OHSS history. An 85-question retrospective survey was conducted online, and the results showed that donors who received GnRH agonist triggers reported milder OHSS compared to those who received hCG or dual triggers. Among donors undergoing multiple retrieval cycles, the severity of OHSS in the second cycle was strongly associated with the severity in the first cycle.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2023)
Article
Biochemistry & Molecular Biology
Franz Felix Konen, Malte Johannes Hannich, Philipp Schwenkenbecher, Matthias Grothe, Konrad Gag, Konstantin Fritz Jendretzky, Stefan Gingele, Kurt-Wolfram Suhs, Torsten Witte, Thomas Skripuletz, Marie Suesse
Summary: This study investigated the cerebrospinal fluid analysis and immune response in patients with early and late onset multiple sclerosis. The results showed that there was no difference in the frequency of cerebrospinal fluid-specific oligoclonal bands between early and late onset multiple sclerosis patients. However, the sensitivity of positive cerebrospinal fluid free light chains kappa fraction was lower in late onset progressive multiple sclerosis patients. The MRZ reaction had the same frequency of positivity in both early and late onset multiple sclerosis patients.
Article
Medicine, General & Internal
Jordan Nunnelee, Francesca Cottini, Qiuhong Zhao, Muhammad Salman Faisal, Patrick Elder, Ashley Rosko, Naresh Bumma, Abdullah Khan, Elvira Umyarova, Srinivas Devarakonda, Don M. Benson, Yvonne A. Efebera, Nidhi Sharma
Summary: This study retrospectively evaluated maintenance therapy in 340 multiple myeloma patients who underwent ASCT and found that continuing maintenance treatment significantly prolonged progression-free and overall survival. Adverse events were the main reason for early discontinuation, while disease progression was the main reason for late discontinuation.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Clinical Neurology
Ermelinda De Meo, Massimo Filippi, Maria Trojano, Giancarlo Comi, Francasco Patti, Vincenzo Brescia Morra, Giuseppe Salemi, Marco Onofrj, Giacomo Lus, Eleonora Cocco, Mattia Fonderico, Valentina Torri Clerici, Giorgia Teresa Maniscalco, Paola Valentino, Antonio Bertolotto, Alessandra Lugaresi, Roberto Bergamaschi, Marco Rovaris, Patrizia Sola, Gioacchino Tedeschi, Ilaria Pesci, Umberto Aguglia, Paola Cavalla, Davide Maimone, Franco Granella, Marika Vianello, Marta Simone, Emilio Portaccio, Maria Pia Amato
Summary: This study aimed to describe and compare the disease course and prognosis of early and late onset pediatric multiple sclerosis. The results showed differences in clinical characteristics between the two groups, with early onset patients exhibiting more severe symptoms and longer disease progression.
ANNALS OF NEUROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Aleksandra Stupak, Tomasz Geca, Anna Kwasniewska, Radoslaw Mlak, Pawel Piwowarczyk, Robert Nawrot, Anna Gozdzicka-Jozefiak, Wojciech Kwasniewski
Summary: A comparative analysis was conducted to assess the impact of bacteria on placental development and function in pregnancies with late fetal growth restriction (FGR). The presence of microorganisms in various components of the pregnancy disproves the theory of the sterile uterus. Bacterial infections have been linked to maternal overproduction of pro-inflammatory cytokines and can cause both short- and long-term problems.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
Neus Falgas, Isabel E. Allen, Salvatore Spina, Harli Grant, Stefanie D. Pina Escudero, Jennifer Merrilees, Rosalie Gearhart, Howard J. Rosen, Joel H. Kramer, William W. Seeley, Thomas C. Neylan, Bruce L. Miller, Gil D. Rabinovici, Lea T. Grinberg, Christine M. Walsh
Summary: In a cohort with biomarker/postmortem-confirmed diagnoses, neuropsychiatric symptoms are more severe in early-onset Alzheimer's disease (EOAD) compared to late-onset Alzheimer's disease (LOAD), with anxiety, night-time behaviors, and motor disturbances being more prominent in EOAD. There are no differences between amnestic/non-amnestic diagnoses, but co-pathologies such as argyrophilic grain disease in LOAD may contribute to increased neuropsychiatric symptoms.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Astronomy & Astrophysics
A. L. B. Ribeiro, R. S. Nascimento, D. F. Morell, P. A. A. Lopes, C. C. Dantas, M. H. S. Fonseca
Summary: We examine the variation in concentration index, radius, and color gradient of 936 early-type galaxies (ETGs) in 48 low-z regular galaxy clusters. Our analysis reveals that the behavior of concentration index and color gradient changes significantly for ETGs with stellar mass around 2x10^11 M. Objects with lower mass showed slight growth in concentration index and constant color gradients, while objects with higher mass showed slight decrease in concentration index and less negative color gradients. In addition, we found that objects with higher mass have smaller R-90 for a given R-50, indicating smaller external growth or even shrinkage possibly due to tidal stripping. Ancient satellites were found to have the highest dark matter fractions, approximately 65%.
MONTHLY NOTICES OF THE ROYAL ASTRONOMICAL SOCIETY
(2023)
Article
Astronomy & Astrophysics
E. -D. Paspaliaris, E. M. Xilouris, A. Nersesian, S. Bianchi, I. Georgantopoulos, V. A. Masoura, G. E. Magdis, M. Plionis
Summary: The aim of this study is to question the general rule that late-type galaxies undergo intense star-formation while early-type galaxies are mostly inactive. The researchers investigated the existence of star-forming early-type and quiescent late-type galaxies in the local Universe and analyzed their physical and structural properties. The results show that a substantial fraction of E/S0 galaxies show ongoing star-formation activity, while a small percentage of late-type galaxies are quiescent.
ASTRONOMY & ASTROPHYSICS
(2022)
Article
Astronomy & Astrophysics
Taniya Parikh, Daniel Thomas, Claudia Maraston, Kyle B. Westfall, Brett H. Andrews, Nicholas Fraser Boardman, Niv Drory, Grecco Oyarzun
Summary: By studying a large sample of galaxies, differences in age, metallicity, and various element abundances between ETGs and LTGs were identified. The age gradients in LTGs were found to be negatively correlated with galaxy mass, while internal processes regulated metallicity in ETGs rather than age. Different galaxy types exhibit distinct gradient characteristics.
MONTHLY NOTICES OF THE ROYAL ASTRONOMICAL SOCIETY
(2021)
Article
Endocrinology & Metabolism
Bella Martazanova, Nona Mishieva, Irina Vedikhina, Anastasia Kirillova, Irina Korneeva, Tatyana Ivanets, Aydar Abubakirov, Gennady T. Sukhikh
Summary: The use of GnRHa triggering in fresh embryo transfer cycles has limitations due to luteal phase insufficiency. Low-dose hCG supplementation can effectively address this issue and achieve comparable pregnancy rates to full-dose hCG.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Endocrinology & Metabolism
Magdalena Zgliczynska, Magdalena Ostrowska, Iwona Szymusik, Michal Ciebiera, Katarzyna Kosinska-Kaczynska
Summary: This article summarizes the changes and influencing factors of thyroid function in multiple pregnancies. Through systematic searching and screening, a total of 12 relevant studies were included. The results show that thyroid function in multiple pregnancies differs from that in single pregnancies, mainly in the early stages of pregnancy. Separate reference ranges are needed to accurately diagnose thyroid diseases in multiple pregnancies.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Margarete M. Voortman, Anna Damulina, Lukas Pirpamer, Daniela Pinter, Alexander Pichler, Christian Enzinger, Stefan Ropele, Gerhard Bachmaier, Juan-Jose Archelos, Gunther Marsche, Michael Khalil
Summary: The study revealed that decreased CSF AOC in MS patients was associated with increased disability and clinical disease activity. However, no correlations with MRI metrics were found. This suggests a need for further investigation into the role of AOC in the progression of MS.
Article
Clinical Neurology
Marie-Christine Reinert, Brenda Huppke, Hannah Hummel-Abmeier, Wiebke Stark, Jutta Gaertner, Peter Huppke
Summary: The results of this study have important implications: pretreatment sNfL levels are a valuable biomarker for underlying disease activity in pediatric patients with MS; pretreatment sNfL levels in pediatric patients with MS have a predictive value for the response to first-line therapy and the necessity of future therapy escalation; high sNfL levels during a relapse are associated with poor recovery in this age group.
Review
Obstetrics & Gynecology
Amir Aviram, Jon F. R. Barrett, Nir Melamed, Elad Mei-Dan
Summary: The mode of delivery in multiple pregnancies has been a topic of debate, with some questions answered by the Twin Birth Study but others remaining outside its scope. Current evidence supports trial of labor in specific cases, but caesarean delivery also has benefits.
AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY MFM
(2022)
Article
Cell & Tissue Engineering
Yoon Young Kim, Bo Bin Choi, Ji Won Lim, Yong Jin Kim, Sung Yob Kim, Seung-Yup Ku
TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2019)
Article
Engineering, Biomedical
Yoon Young Kim, Kyu-Hyung Park, Yong Jin Kim, Moon Suk Kim, Hung Ching Liu, Zev Rosenwaks, Seung-Yup Ku
ACTA BIOMATERIALIA
(2019)
Article
Biochemistry & Molecular Biology
Yoon Young Kim, Byeong-Cheol Kang, Jun Won Yun, Jae Hun Ahn, Yong Jin Kim, Hoon Kim, Zev Rosenwaks, Seung-Yup Ku
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Cell & Tissue Engineering
Yoon Young Kim, Yong Jin Kim, Hoon Kim, Byeong Cheol Kang, Seung-Yup Ku, Chang Suk Suh
TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2019)
Article
Geriatrics & Gerontology
Ki-Jin Ryu, Hyuntae Park, Yong Jin Kim, Kyong Wook Yi, Jung Ho Shin, Jun Young Hur, Tak Kim
Article
Obstetrics & Gynecology
Ki-Jin Ryu, Min Sun Kim, Hyun Kyun Kim, Yong Jin Kim, Kyong Wook Yi, Jung Ho Shin, Jun Young Hur, Tak Kim, Hyuntae Park
Summary: This study found that PCOS is independently associated with an increased incidence of T2DM in Korean women, regardless of obesity status. Screening for T2DM should be considered for Korean women with PCOS.
FERTILITY AND STERILITY
(2021)
Article
Biochemistry & Molecular Biology
Youngjae Ryu, Yong Jin Kim, Yoon Young Kim, Jungwoo Kim, Sung Woo Kim, Hoon Kim, Seung Yup Ku
Summary: This study successfully established a PCOS model in mice using STZ, with findings indicating that low doses of STZ can induce PCOS features without causing diabetes features. Different doses of STZ treatment had varying effects on body weight, blood glucose levels, and hormone levels in mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Yong-Jin Kim, Amin Tamadon, Yoon-Young Kim, Byeong-Cheol Kang, Seung-Yup Ku
Summary: This review focuses on the current knowledge of epigenetic regulation of cardiomyocyte proliferation and differentiation from embryonic and induced pluripotent stem cells through histone modification and microRNAs, the maintenance of pluripotency, and its alteration during cardiac lineage differentiation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Yoon-Young Kim, Kwang-Soo Kim, Yong-Jin Kim, Sung-Woo Kim, Hoon Kim, Seung-Yup Ku
Summary: The study extensively investigated premature ovarian insufficiency in females, identifying differentially expressed genes through RNA sequencing and highlighting the crucial role of miRNAs in regulation, especially in different stages of ovarian development impacting key genes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Obstetrics & Gynecology
Ki-Jin Ryu, Kyong Wook Yi, Yong Jin Kim, Jung Ho Shin, Jun Young Hur, Tak Kim, Jong Bae Seo, Kwang-Sig Lee, Hyuntae Park
Summary: The aim of this study is to analyze the determinants of women's vaginal dryness using machine learning. The random forest method was found to be more effective than linear regression and artificial neural networks in predicting vaginal dryness. The major determinants of vaginal dryness were found to be menopause age, age, menopause, height, and thyroid stimulating hormone.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2022)
Review
Obstetrics & Gynecology
Yong Jin Kim
Summary: Research has shown that there is a balance between risk and benefit in the use of glucocorticoids in assisted reproduction, and previous studies have not provided consistent and reliable evidence to support the effects of glucocorticoids on endometrial receptivity during IVF cycles. Therefore, further investigation is needed to validate their efficacy.
CLINICAL AND EXPERIMENTAL REPRODUCTIVE MEDICINE-CERM
(2021)
Article
Medicine, General & Internal
Dayong Lee, Yong Jin Kim
Summary: Oocyte cryopreservation through vitrification has shown similar clinical pregnancy rates and live birth rates compared to fresh oocytes. Preliminary data supports planned oocyte cryopreservation as a feasible modality resulting in fertility preservation and subsequent live births. However, more well-designed studies are needed to improve counseling and decision-making due to a lack of data on standardized live birth rates, number of oocytes to be collected, and long-term effects on children.
JOURNAL OF THE KOREAN MEDICAL ASSOCIATION
(2022)
Article
Medicine, General & Internal
Ki Jin Ryu, Kyong Wook Yi, Yong Jin Kim, Jung Ho Shin, Jun Young Hur, Tak Kim, Jong Bae Seo, Kwang Sig Lee, Hyuntae Park
Summary: Machine learning was used to analyze factors associated with women's vasomotor symptoms (VMS), with random forest outperforming linear regression and artificial neural networks in predicting VMS. Variable importance analysis from the random forest highlighted several key factors linked to VMS. Comprehensive consideration of thyroid function, lipid profile, liver function, inflammation markers, insulin resistance, monocyte count, cancer antigens, and lung function is essential for managing VMS.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2021)
Article
Education, Scientific Disciplines
Ji Han Lee, Yong Jin Kim, Sung Woo Kim, Hoon Kim, Wonshik Han, Seung-Yup Ku
Summary: This retrospective study reviewed records of 164 women who underwent breast cancer surgery, finding that bone mineral density (BMD) in L1-4, femur neck, and femur total was significantly lower at follow-up than at initial visit. The change in BMD was positively correlated with age and endometrial thickness (EMT) change, suggesting that EMT could be an alternative screening marker for BMD decrease in breast cancer survivors during follow-up.
Article
Medicine, General & Internal
Sung Woo Kim, Yong Jin Kim, Jung Ho Shin, Hoon Kim, Seung-Yup Ku, Chang Suk Suh, Seok Hyun Kim, Young Min Choi
YONSEI MEDICAL JOURNAL
(2019)