Article
Medicine, General & Internal
Yusuf Beebeejaun, Timothy Copeland, Lukasz Polanski, Tarek El Toukhy
Summary: The likelihood of a live birth after single fresh embryo transfer can be predicted based on the number of cryopreserved supernumerary blastocysts, and this relationship is nonlinear and varies based on age group.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Obstetrics & Gynecology
Giovanni Coticchio, Kenji Ezoe, Cristina Lagalla, Kiyoe Shimazaki, Kazuki Ohata, Maya Ninomiya, Natsuki Wakabayashi, Tadashi Okimura, Kazuo Uchiyama, Keiichi Kato, Andrea Borini
Summary: The study showed that the exclusion and extrusion of cells during blastocyst formation have a significant impact on the embryo development and clinical outcomes, especially with negative effects on pregnancy and live birth rates.
HUMAN REPRODUCTION
(2021)
Article
Obstetrics & Gynecology
Sidse Hoyer, Ulrik Schioler Kesmodel, Jorn Aagaard
Summary: The study investigated live birth rates (LBR) and cumulative live birth rates (CLBR) for consecutive fresh and frozen-thawed IVF cycles, as well as CLBR after using blastocyst transfer only in an entire IVF programme. Results showed a considerable increase in IVF success rate when using blastocyst transfer only.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2021)
Article
Obstetrics & Gynecology
Laura Emilie Vexo, Sacha Stormlund, Selma Kloeve Landersoe, Henrik Lovendahl Jorgensen, Peter Humaidan, Christina Bergh, Anne Lis Mikkelsen Englund, Anna Klajnbard, Jeanette Wulff Bogstad, Nina la Cour Freiesleben, Anne Zedeler, Lisbeth Praetorius, Anders Nyboe Andersen, Kristine Lossl, Anja Pinborg, Henriette Svarre Nielsen
Summary: Low-grade inflammation, detected by CRP, is associated with the outcome of IVF, including blastocyst quality and pregnancy outcome. Higher baseline CRP concentrations are negatively associated with live birth rate and are associated with pregnancy loss. However, there is no association between CRP concentrations and the number of good-quality blastocysts. More studies are needed to investigate the impact of low-grade inflammation.
REPRODUCTIVE BIOMEDICINE ONLINE
(2023)
Article
Obstetrics & Gynecology
Maria Carme Pons, Beatriz Carrasco, Natalia Rives, Arantza Delgado, Alvaro Martinez-Moro, Luis Martinez-Granados, Ignacio Rodriguez, Olga Cairo, Irene Cuevas-Saiz, SIG Embryol ASEBIR
Summary: Research question: Can day-5 blastocysts be ranked according to their likelihood of live birth using an objective and user-friendly grading system? Design: A retrospective multicenter study was conducted to assess the morphological and morphometric characteristics of 1044 day-5 blastocysts. The study found that the trophectoderm grade had the highest predictive value for live birth, followed by the blastocyst expansion degree. This new method allows for objective blastocyst assessment, enabling standardization and exportation to other laboratories worldwide.
REPRODUCTIVE BIOMEDICINE ONLINE
(2023)
Article
Obstetrics & Gynecology
Neal Mahutte, Michael Hartman, Lynn Meng, Andrea Lanes, Zhong-Cheng Luo, Kimberly E. Liu
Summary: The thickness of the endometrium has a significant impact on live birth rates in fresh and frozen-thaw embryo transfer cycles. In fresh cycles, increasing endometrial thickness can improve live birth rates until it reaches 10-12 mm, while in frozen cycles, live birth rates plateau after the endometrium measures 7-10 mm. Endometrial thickness below 6 mm is clearly associated with a dramatic reduction in live birth rates.
FERTILITY AND STERILITY
(2022)
Article
Obstetrics & Gynecology
Zoha Saket, Karin Kallen, Kersti Lundin, Asa Magnusson, Christina Bergh
Summary: The study shows that cumulative live birth rate per oocyte aspiration has significantly increased over an 11-year period, from 27.0% to 36.3%, in parallel with an increase in blastocyst transfer and vitrification. The findings suggest that blastocyst transfer, especially in frozen embryo transfer cycles using vitrification, is a key factor contributing to the improved live birth rates over time.
HUMAN REPRODUCTION OPEN
(2021)
Article
Multidisciplinary Sciences
I Erlich, A. Ben-Meir, I Har-Vardi, J. Grifo, F. Wang, C. Mccaffrey, D. McCulloh, Y. Or, L. Wolf
Summary: This study proposes a novel method that trains a classifier conditioned on the time since fertilization, improving the predictive accuracy of embryo development potential. The results show superiority over previously reported methods, including commercial systems and professional decisions.
SCIENTIFIC REPORTS
(2022)
Article
Medicine, Research & Experimental
Yuan Fang, Ye He, Wanlu Wang, Zhiguo Zhang, Ping Zhou, Yunxia Cao, Xiaojin He, Yuping Xu, Zhaolian Wei
Summary: The controversy remains on whether only low-grade blastocysts should undergo freeze-thaw transfer during the in vitro fertilization/intracytoplasmic sperm injection cycle, as high-quality embryos cannot be obtained from some patients. The study aimed to identify factors that may affect the live birth outcome.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2023)
Article
Obstetrics & Gynecology
Naama Steiner, Naama Al Mamari, Keren Rotshenker-Olshinka, Suhaib Khayat, Nabigah Alzawawi, Weon-Young Son, Michael H. Dahan
Summary: Among patients who conceived through IVF cycles with single fresh Gardner's scored blastocyst transfers, blastocyst morphology did not have a significant impact on day16 beta-hCG serum levels or pregnancy outcomes. Both blastocyst grade and stage were found to be not associated with live births after controlling for confounding effects.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2021)
Article
Obstetrics & Gynecology
David J. McLernon, Edwin-Amalraj Raja, James P. Toner, Valerie L. Baker, Kevin J. Doody, David B. Seifer, Amy E. Sparks, Ethan Wantman, Paul C. Lin, Siladitya Bhattacharya, Bradley J. Van Voorhis
Summary: This study aims to develop in vitro fertilization (IVF) prediction models to estimate individualized chances of cumulative live birth, providing guidance for IVF treatment at different time points.
FERTILITY AND STERILITY
(2022)
Article
Endocrinology & Metabolism
Mingze Du, Junwei Zhang, Zhancai Wei, Li Li, Xinmi Liu, Manman Liu, Xingling Wang, Yichun Guan
Summary: A retrospective cohort study found no evidence that season and temperature on oocyte retrieval day affect the cumulative live birth rate and time to live birth.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Obstetrics & Gynecology
Beatriz Carrasco, Maria Carme Pons, Monica Parriego, Montserrat Boada, Sandra Garcia, Nikolaos P. Polyzos, Anna Veiga
Summary: There is an imbalance in the sex ratio at the blastocyst stage of human embryos, with a higher proportion of male embryos. Male embryos also exhibit a higher rate of aneuploidy, but the ability to implant and lead to a live birth is similar between the sexes.
REPRODUCTIVE BIOMEDICINE ONLINE
(2022)
Article
Reproductive Biology
Mungunshagai Baatarsuren, Davaakhuu Sengebaljir, Chinzorig Ganbaatar, Tserendolgor Tserendorj, Belguune Erdenekhuyag, Lkhagvasuren Baljinnyam, Enkhdemberel Radnaa, Amarjargal Dorjpurev, Gereltsetseg Ganbat, Tsogzolmaa Boris, Azjargal Khangarid, Jambaldorj Jamiyansuren
Summary: The selection of the best blastocyst is crucial in single blastocyst transfer cycles, and it is based on blastocyst morphological parameters such as inner cell mass (ICM), trophectoderm (TE), and its inner diameter. This study aimed to investigate the relationship between morphological parameters and sex ratio after single vitrified-warmed blastocyst transfer (SVBT). The results showed that TE morphology, female age, and blastocyst day were highly correlated with clinical pregnancy rate (CPR) and live birth rate (LBR). A grade ICM was significantly associated with higher CPR compared to C grade. Moreover, the probability of male gender was 2.8 times higher in singleton live births with A grade trophectoderm than C grade. ICM morphology, LBR, and sex ratio were not related to trophoectoderm grade. Higher grade TE, younger age of the patient, and selection of day 5 blastocysts were associated with higher frequency of CPR and LBR. Therefore, considering these parameters is a better method for selecting the best embryo. On the other hand, selecting blastocysts for transfer based on quality and morphological parameters may unintentionally bias the secondary sex ratio (SSR) in favor of female births.
REPRODUCTIVE BIOLOGY
(2022)
Article
Obstetrics & Gynecology
Jie Wang, Zhenyu Diao, Junshun Fang, Lihua Zhu, Zhipeng Xu, Fei Lin, Ningyuan Zhang, Linjun Chen
Summary: This retrospective study suggests that the day 3 embryo cell number has an influence on the clinical pregnancy and live birth rates of day 5 single blastocyst transfer in frozen embryo transfer (FET) cycles. As the day 3 embryo cell number increases, the clinical pregnancy and live birth rates also increase, especially when fair- and poor-quality blastocysts are transferred.
BMC PREGNANCY AND CHILDBIRTH
(2022)