Article
Obstetrics & Gynecology
Jennifer J. Yland, Yu-Han Chiu, Paolo Rinaudo, John Hsu, Miguel A. Hernan, Sonia Hernandez-Diaz
Summary: For women with PCOS, letrozole was associated with higher risks of pregnancy, livebirth, and neonatal outcomes compared to clomiphene. In women with unexplained infertility, the two treatments resulted in comparable outcomes.
HUMAN REPRODUCTION
(2022)
Article
Obstetrics & Gynecology
Shavina Bansal, Manu Goyal, Charu Sharma, Shashank Shekhar
Summary: In women with polycystic ovarian syndrome, letrozole may be a better option for ovulation induction compared to clomiphene citrate, as it results in higher pregnancy rates, shorter time to pregnancy, and lower chances of multiple pregnancies due to higher monofollicular development.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2021)
Article
Public, Environmental & Occupational Health
Pattraporn Chera-aree, Sirikul Tanpong, Isarin Thanaboonyawat, Pitak Laokirkkiat
Summary: This study aimed to compare the efficacy of the combination of clomiphene citrate (CC) and letrozole with CC alone in inducing ovulation in infertile women with ovulatory dysfunction. The results showed no significant difference between the two treatment groups in terms of ovulation rate and other observed outcomes in one cycle. Further studies are needed to validate and extend these findings.
Article
Obstetrics & Gynecology
Ying Liang, Qing Guo, Xiao-Hua Wu, Li-Nan Zhang, Jun Ge, Mei-Ling Xu, Zheng-Li Feng, Xiao-Qian Wu
Summary: Adding CC/LE to IVF ovulation induction has certain efficacy in terms of low cost and low OHSS incidence. CC/LE deserves more recommendations as a responsible strategy in high responders for advantageous pregnancy outcomes, while the strategy needs to be considered with more comprehensive factors in normal responders.
BMC PREGNANCY AND CHILDBIRTH
(2021)
Article
Obstetrics & Gynecology
Soumya Ranjan Panda, Vijayan Sharmila, Vinoth Kumar Kalidoss, Smrutismita Hota
Summary: The study evaluated the efficacy of combining letrozole and clomiphene citrate in inducing ovulation in infertile women with polycystic ovary syndrome. The combination treatment showed a higher ovulation rate compared to letrozole alone.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Medicine, General & Internal
Mehnaz Khakwani, Rashida Parveen, Shazia Yousaf, Ayesha Uzaima Tareen
Summary: This study compared the efficacy of LTZ and CC for ovulation induction in patients with PCOS and found that LTZ had significantly better efficacy than CC, and it could significantly improve endometrial thickness.
PAKISTAN JOURNAL OF MEDICAL SCIENCES
(2022)
Review
Obstetrics & Gynecology
Ahmed Abu-Zaid, Abdulrahim Gari, Hussein Sabban, Majed Saeed Alshahrani, Khalid Khadawardi, Ehab Badghish, Rayan Alsghan, Ibtihal Abdulaziz Bukhari, Abdullah Alyousef, Mohammed Abuzaid, Saud Abdullah Alsharif, Osama Alomar, Aliyah Hadi Alamery, Saeed Baradwan
Summary: A systematic review and meta-analysis showed that letrozole has a positive effect on pregnancy outcomes in patients with polycystic ovary syndrome, including increased endometrial thickness, monofollicular development, and ovulation and pregnancy rates, compared to clomiphene citrate.
REPRODUCTIVE SCIENCES
(2023)
Article
Endocrinology & Metabolism
Li Wang, Shulan Lv, Fen Li, E. Bai, Xiaofeng Yang
Summary: This study compared endometrial receptivity during implantation windows among letrozole, clomiphene citrate, and natural cycle in polycystic ovary syndrome (PCOS) patients. The results showed that letrozole had superior endometrial receptivity compared to clomiphene citrate, leading to higher clinical pregnancy and ongoing pregnancy rates. Endometrial flow index during the implantation window was found to have the highest predictive value for pregnancy.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Medicine, General & Internal
Sebastian Franik, Quang-Khoi Le, Jan Am Kremer, Ludwig Kiesel, Cindy Farquhar
Summary: For infertile women with anovulatory PCOS, letrozole appears to improve live birth rates and pregnancy rates compared to SERMs when used for ovulation induction followed by intercourse. There is high-certainty evidence that OHSS rates are similar between letrozole and SERMs, with no difference in miscarriage rate and multiple pregnancy rate. It is uncertain if letrozole increases live birth rates compared to LOD. Updated with high-quality trials and removal of those with data validity concerns, the evidence base has been strengthened.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2022)
Article
Obstetrics & Gynecology
Lu Zhou, Jing Fu, Dong Liu, Qiuyi Wang, Hengxi Chen, Shiyuan Yang, Wei Huang
Summary: For infertile women with minimal to mild endometriosis, ovulation induction with letrozole or clomiphene citrate after laparoscopy significantly increases ovulation rate, which are comparable between them; but does not demonstrate a significant advantage on improving pregnancy rate and live-birth rate when compared to laparoscopy alone. Further research may focus on prolonging cycles of ovulation induction or choosing alternative ovarian stimulation protocols, and more RCTs are needed to compare the efficacy of letrozole with CC in ovulation induction.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2022)
Article
Obstetrics & Gynecology
E. M. Bordewijk, T. Jannink, N. S. Weiss, T. de Vries, M. Nahuis, A. Hoek, M. Goddijn, B. W. Mol, M. van Wely, M-Ovin Study Grp
Summary: This study aimed to investigate the long-term outcomes of using gonadotrophins versus clomiphene citrate (CC) in women with normogonadotropic anovulation and clomiphene failure. The results showed that about four in five women were able to have a live birth after experiencing clomiphene failure, with no significant difference in pregnancy outcomes among the allocated groups.
HUMAN REPRODUCTION
(2023)
Article
Endocrinology & Metabolism
Hsin-Ta Lin, Meng-Hsing Wu, Li-Chung Tsai, Ta-Sheng Chen, Huang-Tz Ou
Summary: This retrospective study found that the co-administration of clomiphene citrate and letrozole in mild ovarian stimulation may increase the ratio of high-quality oocytes and yield comparable fertilization rate and pregnancy outcomes for POSEIDON Group 4 patients.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Lucie Huyghe, Camille Robin, Agathe Dumont, Christine Decanter, Maeva Kyheng, Didier Dewailly, Sophie Catteau-Jonard, Geoffroy Robin
Summary: The objective of this study was to identify clinical, biological, and ultrasound factors that may predict resistance to 50 mg/day of CC in the first cycle of treatment for women with anovulatory PCOS. The study found that higher levels of AMH and lower levels of SHBG were significantly associated with resistance to 50 mg/day of CC. However, no satisfactory thresholds have been established for predicting resistance to 50 mg CC.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Health Care Sciences & Services
Ahmed E. Altyar, Marian S. Boshra, Ahmed Essam Abou Warda, Sherwet M. Shawkey, Sara Abdallah Mohamed Salem, Rania M. Sarhan, Neven Sarhan
Summary: This study found that oral estradiol combined with clomiphene citrate can improve endometrial thickness and clinical pregnancy rates, especially in patients with unexplained infertility for less than two years. However, the use of sildenafil had a poorer effect. Sildenafil commonly causes mild headaches.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Obstetrics & Gynecology
L. O. Kettner, N. B. Matthiesen, C. H. Ramlau-Hansen, U. S. Kesmodel, T. B. Henriksen
Summary: The study suggests that fertility treatment with clomiphene citrate may be associated with a small increased risk of childhood idiopathic generalized epilepsy and focal epilepsy.
HUMAN REPRODUCTION
(2021)
Article
Obstetrics & Gynecology
Anat Hershko Klement, Nivin Samara, Amir Weintraub, Frederic Mitri, Yaakov Bentov, Paul Chang, Dan Nayot, Robert F. Casper
GYNECOLOGIC AND OBSTETRIC INVESTIGATION
(2018)
Article
Endocrinology & Metabolism
Anat Hershko Klement, Mitri Frederic, Yaakov Bentov, Paul Chang, Dan Nayot, Jigal Haas, Robert F. Casper
GYNECOLOGICAL ENDOCRINOLOGY
(2018)
Article
Genetics & Heredity
Rawad Bassil, Robert Casper, Nivin Samara, Tzu-Bou Hsieh, Eran Barzilay, Raoul Orvieto, Jigal Haas
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2018)
Article
Endocrinology & Metabolism
Jigal Haas, Rawad Bassil, Noa Gonen, Jim Meriano, Andrea Jurisicova, Robert F. Casper
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2018)
Review
Obstetrics & Gynecology
Craig Niederberger, Antonio Pellicer, Jacques Cohen, David K. Gardner, Gianpiero D. Palermo, Claire L. O'Neill, Stephen Chow, Zev Rosenwaks, Ana Cobo, Jason E. Swain, William B. Schoolcraft, Rene Frydman, Lauren A. Bishop, Davora Aharon, Catherine Gordon, Erika New, Alan Decherney, Seang Lin Tan, Richard J. Paulson, James M. Goldfarb, Mats Brannstrom, Jacques Donnez, Sherman Silber, Marie-Madeleine Dolmans, Joe Leigh Simpson, Alan H. Handyside, Santiago Munne, Cristina Eguizabal, Nuria Montserrat, Juan Carlos Izpisua Belmonte, Alan Trounson, Carlos Simon, Togas Tulandi, Linda C. Giudice, Robert J. Norman, Aaron J. Hsueh, Yingpu Sun, Neri Laufer, Ronit Kochman, Talia Eldar-Geva, Bruno Lunenfeld, Diego Ezcurra, Thomas D'Hooghe, Bart C. J. M. Fauser, Basil C. Tarlatzis, David R. Meldrum, Robert F. Casper, Human M. Fatemi, Paul Devroey, Daniela Galliano, Matts Wikland, Mark Sigman, Richard A. Schoor, Marc Goldstein, Larry I. Lipshultz, Peter N. Schlegel, Alayman Hussein, Robert D. Oates, Robert E. Brannigan, Heather E. Ross, Guido Pennings, Susan C. Klock, Simon Brown, Andre Van Steirteghem, Robert W. Rebar, Andrew R. LaBarbera
FERTILITY AND STERILITY
(2018)
Article
Reproductive Biology
Stephanie Yacoub, Kenneth Cadesky, Robert F. Casper
Summary: The study demonstrates that using follitropin delta with an individualized dosing algorithm for ovarian stimulation in PCOS patients can safely yield a high number of high-quality oocytes with low risk of complications.
JOURNAL OF OVARIAN RESEARCH
(2021)
Article
Genetics & Heredity
Robert F. F. Casper
Summary: Preimplantation genetic testing for aneuploidy (PGT-A) is commonly used in IVF cycles, but it has limitations such as artifacts introduced by whole genome amplification and the challenge of interpreting results due to mosaicism in human embryos. Clinical data suggests that PGT-A may be harmful and its hypothesized benefits may be modest at best.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2023)
Meeting Abstract
Obstetrics & Gynecology
J. Haas, R. Bassil, R. Casper
HUMAN REPRODUCTION
(2018)
Letter
Obstetrics & Gynecology
Robert F. Casper, Togas Tulandi
JOURNAL OF OBSTETRICS AND GYNAECOLOGY CANADA
(2018)
Meeting Abstract
Obstetrics & Gynecology
Chaula Mehta, Jigal Haas, Rawad Bassil, Eran Zilberberg, Robert Casper, Ken Cadesky, Dan Nayot
REPRODUCTIVE SCIENCES
(2018)
Meeting Abstract
Obstetrics & Gynecology
Jigal Haas, Rawad Bassil, Andrea Jurisicova, Robert F. Casper
REPRODUCTIVE SCIENCES
(2018)
Meeting Abstract
Obstetrics & Gynecology
Rawad Bassil, Jigal Haas, Ramsey Smith, Chaula Mehta, Eran Zilberberg, Robert F. Casper
REPRODUCTIVE SCIENCES
(2018)
Letter
Obstetrics & Gynecology
B. Anthony Armson, David S. Allan, Robert F. Casper
JOURNAL OF OBSTETRICS AND GYNAECOLOGY CANADA
(2018)
Meeting Abstract
Obstetrics & Gynecology
C. Wu, R. Bassil, J. Haas, E. Barzilay, D. Nayot, R. Casper
HUMAN REPRODUCTION
(2017)
Meeting Abstract
Obstetrics & Gynecology
J. Haas, J. S. Meriano, R. Bassil, R. Casper
FERTILITY AND STERILITY
(2017)
