Article
Urology & Nephrology
Nahid Punjani, Ryan Flannigan, Caroline Kang, Francesca Khani, Peter N. Schlegel
Summary: The study aimed to determine the association between testicular histopathological heterogeneity and sperm retrieval rates (SRRs) in men with nonobstructive azoospermia (NOA) undergoing microdissection testicular sperm extraction (mTESE). The findings revealed that increasing testicular histopathological heterogeneity is correlated with higher SRRs in men with NOA, driven by the identification of focal areas of spermatogenesis. These results highlight the importance of histology in potentially predicting the chance of sperm retrieval in future mTESE procedures.
JOURNAL OF UROLOGY
(2021)
Article
Obstetrics & Gynecology
A. H. Hansen, L. Priskorn, L. S. Hansen, E. Carlsen, U. N. Joensen, F. M. Jacobsen, C. F. S. Jensen, N. Jorgensen
Summary: This study aimed to investigate whether prior testicular torsion is associated with testicular function in young men from the general population. The results showed no differences in semen parameters between men who had experienced testicular torsion and controls. However, subtle alterations in reproductive hormones were observed, with higher FSH and lower inhibin B levels in men with prior testicular torsion. Follow-up studies are needed to assess any long-term consequences for fertility.
HUMAN REPRODUCTION
(2023)
Article
Obstetrics & Gynecology
Ahmad Aboukhshaba, Nahid Punjani, Sofia Doukakis, Nikica Zaninovic, Gianpiero Palermo, Peter N. Schlegel
Summary: The study aimed to evaluate the impact of sperm characteristics on intracytoplasmic sperm injection (ICSI) outcomes in men with nonobstructive azoospermia (NOA) following microdissection testicular sperm extraction (mTESE). The results showed that specific sperm defects did not completely preclude the chance of clinical pregnancy. This study is the first comprehensive evaluation of the importance of these characteristics in ICSI outcomes.
FERTILITY AND STERILITY
(2022)
Article
Urology & Nephrology
Christian Fuglesang S. Jensen, Dana A. Ohl, Mikkel Fode, Niels Jorgensen, Aleksander Giwercman, Niels Henrik Bruun, Angel Elenkov, Anna Klajnbard, Claus Y. Andersen, Lise Aksglaede, Marie Louise Grondahl, Mette C. Bekker, Jens Sonksen
Summary: This study compared mTESE and multiple needle-pass TESA in men with NOA, and found that mTESE had a higher sperm retrieval rate than multiple needle-pass TESA.
Review
Medicine, General & Internal
Evangelia Billa, George A. Kanakis, Dimitrios G. Goulis
Summary: Testicular sperm extraction (TESE) is an effective surgical procedure for treating infertility due to non-obstructive azoospermia, but it may cause testicular damage and lead to hypogonadism. Patients with Klinefelter syndrome are more likely to experience profound and longer-lasting hypogonadism compared to other causes of NOA.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Health Care Sciences & Services
Aris Kaltsas, Eleftheria Markou, Athanasios Zachariou, Fotios Dimitriadis, Evangelos N. Symeonidis, Athanasios Zikopoulos, Charalampos Mamoulakis, Dung Mai Ba Tien, Atsushi Takenaka, Nikolaos Sofikitis
Summary: This study aimed to assess the efficacy of diagnostic testicular biopsy (DTB) in predicting sperm retrieval success via therapeutic testicular biopsy (TTB) and to understand the role of systemic inflammation in microdissection testicular sperm extraction (mTESE) outcomes. The findings question the necessity of an initial DTB and suggest a possible link between systemic inflammation and reduced sperm retrieval during mTESE. The study emphasizes the need for further research to refine diagnostic approaches and deepen the understanding of factors influencing sperm retrieval in NOA patients, ultimately enhancing their prospects of biological parenthood.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Obstetrics & Gynecology
Georgios E. Papadakis, Benedicte de Kalbermatten, Alexandre Dormoy, Sylvie Salenave, Severine Trabado, Oceana Vieira-Pinto, Carine Richa, Peter Kamenicky, Philippe Chanson, Luigi Maione, Nelly Pitteloud, Jacques Young
Summary: Cushing's syndrome (CS) affects the gonadotrope axis and testicular functions differently depending on the intensity of hypercortisolism and underlying etiology. Excess cortisol caused by CS leads to varying degrees of hypogonadotropic hypogonadism (HH), with more severe impairment in men with intense hypercortisolism associated with paraneoplastic/ectopic adrenocorticotrophic hormone (ACTH) secretion (EAS).
HUMAN REPRODUCTION
(2023)
Article
Obstetrics & Gynecology
Ryan Lee, Luke Witherspoon, Meghan Robinson, Jeong Hyun Lee, Simon P. Duffy, Ryan Flannigan, Hongshen Ma
Summary: A machine learning algorithm was developed to detect rare human sperm in semen and microsurgical testicular sperm extraction (microTESE) samples using bright-field (BF) microscopy for nonobstructive azoospermia patients. The algorithm achieved high precision and sensitivity in both validation and testing stages.
FERTILITY AND STERILITY
(2022)
Article
Urology & Nephrology
Aaron Brant, Nahid Punjani, Nikica Zaninovic, Gianpiero D. Palermo, Zev Rosenwaks, Peter N. Schlegel
Summary: Cancer treatments such as chemotherapy and radiation may result in male infertility, but chemotherapy alone may have better outcomes for fertility preservation compared to combined chemotherapy and radiation. Pelvic radiation therapy is associated with the worst prognosis for successful treatment with microsurgical sperm retrieval and in vitro fertilization.
JOURNAL OF UROLOGY
(2022)
Article
Andrology
Daniel J. Wu, Odgerel Badamjav, Vikrant V. Reddy, Michael Eisenberg, Barry Behr
Summary: The computer-aided sperm analysis (CASA) system developed utilizing deep learning technology showed near human-level performance in identifying sperm in testicular biopsy samples. This technology has the potential to significantly improve the efficiency of finding sperm in such samples.
ASIAN JOURNAL OF ANDROLOGY
(2021)
Article
Genetics & Heredity
Aurelie Dewaele, Emilie Dujardin, Marjolaine Andre, Audrey Albina, Helene Jammes, Frank Giton, Eli Sellem, Genevieve Jolivet, Eric Pailhoux, Maelle Pannetier
Summary: This study investigates the role of estrogens in male reproductive system using a rabbit model. The findings suggest that testicular estrogens may be involved in sperm development and acquisition of motility.
Article
Oncology
Donovan Chan, Kathleen Oros Klein, Antoni Riera-Escamilla, Csilla Krausz, Cristian O'Flaherty, Peter Chan, Bernard Robaire, Jacquetta M. Trasler
Summary: This study aims to determine the impact of HD and TC and their treatments on sperm DNA methylation. The results show that imprinted gene methylation is not affected in sperm before or after treatment. However, sperm epigenetic defects are still evident in some cancer survivors up to 2 years post-treatment.
CLINICAL EPIGENETICS
(2023)
Article
Genetics & Heredity
Jing-Ping Li, Cong-Qi Du, Zu-Bo Liu, Feng-Bin Zhang, Le-Jun Li, Jing-Gen Wu, Yong-Hong Tian, Zhong-Yan Liang, Chong Chen, Fan Jin
Summary: This study developed an integrated predictive model to assist azoospermic men in making better decisions before undergoing testicular sperm aspiration (TESA). The model incorporates multiple factors for prediction and demonstrates good accuracy and calibration.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2022)
Article
Urology & Nephrology
Mohammad H. Alkandari, Joseph Moryousef, Simon Phillips, Armand Zini
Summary: In men with severe oligozoospermia, TESA and micro-TESE are equally successful sperm retrieval techniques, while in men with cryptozoospermia, sperm retrieval rates are significantly higher with micro-TESE than TESA.
Article
Andrology
Mohammad H. Alkandari, David Bouhadana, Armand Zini
Summary: The study found that men with severe oligozoospermia are unlikely to require a bilateral testicular exploration during micro-TESE. Most men with cryptozoospermia can have successful sperm retrieval through micro-TESE, with the majority only needing a unilateral exploration. On the other hand, over 50% of men with nonobstructive azoospermia will require a bilateral micro-TESE.
Article
Andrology
Sandro C. Esteves, Francesco Lombardo, Nicolas Garrido, Juan Alvarez, Armand Zini, Giovanni M. Colpi, Jackson Kirkman-Brown, Sheena E. M. Lewis, Lars Bjorndahl, Ahmad Majzoub, Chak-Lam Cho, Pedro Vendeira, Jorge Hallak, Edouard Amar, Marcello Cocuzza, Fabiola C. Bento, Rita C. Figueira, Romualdo Sciorio, Rita J. Laursen, Ahmad M. Metwalley, Sunil K. Jindal, Sijo Parekattil, Ranjith Ramasamy, Carlo Alviggi, Peter Humaidan, John L. Yovich, Ashok Agarwal
Summary: Delaying non-urgent gamete cryopreservation services may be detrimental for subgroups of male infertility patients, and it is suggested to modify the current recommendations and provide a permissive approach similar to that for cancer patients. Postponing diagnostic semen analysis and sperm banking for specific patients may compromise their prospects of biological parenthood.
Article
Obstetrics & Gynecology
Mauro Cozzolino, Irene Hervas, Rocio Rivera-Egea, Antonio Pellicer, Nicolas Garrido
Summary: The study found that using donor spermatozoa after the first failed oocyte donation cycle can improve IVF outcomes. The cumulative live birth rate (CLBR) curves for using autologous or donor spermatozoa can be used to determine the cumulative chances of live birth and provide guidance on when to replace spermatozoa.
REPRODUCTIVE BIOMEDICINE ONLINE
(2021)
Article
Health Care Sciences & Services
Miriam Cervan-Martin, Lara Bossini-Castillo, Rocio Rivera-Egea, Nicolas Garrido, Saturnino Lujan, Gema Romeu, Samuel Santos-Ribeiro, Jose A. Castilla, M. Carmen Gonzalvo, Ana Clavero, F. Javier Vicente, Andrea Guzman-Jimenez, Claudia Costa, Ines Llinares-Burguet, Chiranan Khantham, Miguel Burgos, Francisco J. Barrionuevo, Rafael Jimenez, Josvany Sanchez-Curbelo, Olga Lopez-Rodrigo, M. Fernanda Peraza, Iris Pereira-Caetano, Patricia I. Marques, Filipa Carvalho, Alberto Barros, Lluis Bassas, Susana Seixas, Joao Goncalves, Sara Larriba, Alexandra M. Lopes, Rogelio J. Palomino-Morales, F. David Carmona
Summary: The study identified a significant difference in allele frequencies of USP8-rs7174015 between the NOA group, the control group, and the SO group, suggesting a possible association of this gene with male infertility. Other genetic associations were found for EPSTI1-rs12870438 and PSAT1-rs7867029 with SO, as well as TUSC1-rs10966811 with TESE success in the context of non-obstructive azoospermia.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Marta Gianzo, Itziar Urizar-Arenaza, Iraia Munoa-Hoyos, Zaloa Larreategui, Nicolas Garrido, Jon Irazusta, Nerea Subiran
Summary: The study confirmed the presence of (pro)renin receptor in human sperm and found that semen samples with higher percentages of PRR-positive spermatozoa are associated with poor sperm motility and embryo development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Obstetrics & Gynecology
Mauro Cozzolino, Juan Antonio Garcia-Velasco, Marcos Meseguer, Antonio Pellicer, Jose Bellver
Summary: The study found that obese women have a higher risk of miscarriage after euploid embryo transfer compared to women with normal weight, suggesting that factors other than chromosomal abnormalities may be responsible for this outcome.
FERTILITY AND STERILITY
(2021)
Article
Obstetrics & Gynecology
Alison Campbell, David K. Gardner, Marcos Meseguer, Kathleen A. Miller, Markus Montag, Gianpiero D. Palermo, Stephanie Cheung, Derek Keating, Philip Xie, Zev Rosenwaks, Laura Rienzi, Federica Innocenti, Danilo Cimadomo, Filippo Maria Ubaldi, Denny Sakkas, Michael J. Tucker, Liesl Nel-Themaat, Carlos Simon
Summary: This article gathers 9 thought leaders and their team members to discuss their ideas about the future of in vitro fertilization and the andrology laboratory. Despite the progress and innovation in the laboratory over the years, there is still important work to be done in technology and processes for future development.
FERTILITY AND STERILITY
(2021)
Editorial Material
Obstetrics & Gynecology
Carlos Simon, Alison Campbell, David K. Gardner, Marcos Meseguer, Kathleen A. Miller, Markus Montag, Gianpiero D. Palermo, Stephanie Cheung, Derek Keating, Philip Xie, Zev Rosenwaks, Laura Rienzi, Federica Innocenti, Danilo Cimadomo, Filippo Maria Ubaldi, Denny Sakkas, Michael J. Tucker, Liesl Nel-Themaat
Summary: The in vitro fertilization and andrology laboratories are at the forefront of assisted reproductive technologies, constantly evolving in techniques, technology, and testing to achieve the best embryo for transfer. The Views and Interviews series aims to gather thought leaders in the field to envision the future of these laboratories in the next 10 years.
FERTILITY AND STERILITY
(2021)
Editorial Material
Obstetrics & Gynecology
M. Angeles Valera, Marcos Meseguer
FERTILITY AND STERILITY
(2021)
Article
Obstetrics & Gynecology
Maria Angeles Valera, Carmela Albert, Julian Marcos, Zaloa Larreategui, Lorena Bori, Marcos Meseguer
Summary: Culturing embryos in a high relative humidity atmosphere using a time-lapse integrated incubator and single-step culture medium can improve clinical outcomes, especially for embryos undergoing preimplantation genetic testing.
HUMAN REPRODUCTION
(2022)
Review
Obstetrics & Gynecology
Pedro Brandao, Nicolas Garrido
Summary: Commercial surrogacy is a common practice despite significant ethical and legal dilemmas. Due to the variation in national legislations, patients often turn to international commercial surrogacy programs.
REVISTA BRASILEIRA DE GINECOLOGIA E OBSTETRICIA
(2022)
Editorial Material
Obstetrics & Gynecology
Carla Gimenez-Rodriguez, Marcos Meseguer
FERTILITY AND STERILITY
(2023)
Article
Urology & Nephrology
Sarah Kimmins, Richard A. Anderson, Christopher L. R. Barratt, Hermann M. Behre, Sarah R. Catford, Christopher J. De Jonge, Geraldine Delbes, Michael L. Eisenberg, Nicolas Garrido, Brendan J. Houston, Niels Jorgensen, Csilla Krausz, Ariane Lismer, Robert I. Mclachlan, Suks Minhas, Tim Moss, Allan Pacey, Laerke Priskorn, Stefan Schlatt, Jacquetta Trasler, Leonardo Trasande, Frank Tuettelmann, Monica Hebe Vazquez-Levin, Joris A. Veltman, Feng Zhang, Moira K. O'Bryan
Summary: Currently, there is a lack of understanding and awareness about the causes of male infertility and the importance of male reproductive health. This leads to standardized treatment strategies using medically assisted reproduction techniques, which overlook the potential co-morbidities and shift the burden to women. To improve male reproductive health, it is essential to establish centers for data and sample collection and study the effects of genetics, epigenetics, and environment on fertility and offspring health. Personalized treatment protocols should be developed and education about infertility should be increased.
NATURE REVIEWS UROLOGY
(2023)
Article
Obstetrics & Gynecology
Lorena Bori, Marcos Meseguer
Summary: IVF techniques are increasingly being automated in the laboratory, reducing the manual tasks of embryologists. This shift towards automation will lead to the emergence of new functions related to data capture and communication with other professionals and patients.
REPRODUCTIVE BIOMEDICINE ONLINE
(2021)
