Article
Obstetrics & Gynecology
Xiaoxia Fu, Mengyun Yao, Chaoshuang Ye, Tao Fang, Ruijin Wu
Summary: Endometriosis, characterized as a tumor-like disease, shows increased levels of OPN in tissues and serum of patients. OPN regulates uPA expression through the PI3K pathway, affecting cell migration capabilities.
REPRODUCTIVE SCIENCES
(2021)
Article
Endocrinology & Metabolism
Jing Zhang, Ying Hou, Lichao Sheng, Zhiyi Wang
Summary: This study reveals the regulatory networks involving miR-223-3p in endometriosis and finds that miR-223-3p inhibitor restrains the progression of ESCs by elevating FBXW7 expression.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2022)
Article
Health Care Sciences & Services
Jinggang Li, Xiaofei Guan, Chongyun Xu, Jingyun Jia, Ling Zhang, Hui Han
Summary: This study found that miR-206 is downregulated in EM and miR-206 mimic inhibits cell proliferation, migration, and invasion while promoting cell apoptosis in EM. Furthermore, miR-206 inhibits tumor growth in vivo. Additionally, MALAT1 is upregulated in EM and is indicated to be a target of miR-206.
JOURNAL OF HEALTHCARE ENGINEERING
(2022)
Article
Cell Biology
Min Wu, Yi Zhang
Summary: The study revealed that miR-182 targets RELA directly and inhibits the NF-kappa B signaling pathway, thereby attenuating the proliferation, migration, invasion, EMT, and inflammatory response of endometrial stromal cells in endometriosis.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Article
Cell Biology
Guojing Li, Yu Lin, Yili Zhang, Nihao Gu, Bingxin Yang, Shan Shan, Na Liu, Jing Ouyang, Yisai Yang, Feng Sun, Hong Xu
Summary: Endometriosis, a chronic disorder characterized by abnormal distribution of tissue, can cause iron overload and oxidative stress. The study found that ferroptosis of endometrial stromal cells can trigger the secretion of cytokines, promoting angiogenesis in adjacent lesions. VEGFA and IL8, important angiogenic factors, are upregulated in ectopic lesions. These findings provide a rationale for clinical practice and drug development for endometriosis.
CELL DEATH DISCOVERY
(2022)
Article
Obstetrics & Gynecology
Yingchen Wu, Hao Wang, Yi Li, Yangzhi Li, Yihua Liang, Guangzheng Zhong, Qingxue Zhang
Summary: The study revealed higher expression of serum and glucocorticoid-regulated kinase 1 (SGK1) in adenomyosis, which promotes cell migration and invasion by regulating downstream molecules and proteins.
REPRODUCTIVE SCIENCES
(2022)
Article
Cell Biology
Shun Zhou, Chengyi Huang, Wei Wang, Juan Liu
Summary: MiR-370-3p plays a crucial role in the progression of endometriosis, influencing the biological functions of hEM15A cells by targeting EDN1. It inhibits proliferation, metastasis, and invasion capacities while promoting apoptosis.
CELL BIOLOGY INTERNATIONAL
(2021)
Article
Developmental Biology
Faying Liu, Zengming Li, Jiubai Guo, Shufen Fang, Jiangyan Zhou, Bianna Cao, Jun Liu, Yulan Yi, Xiaoqun Yuan, Xiaoyun Xu, Ouping Huang, Liqun Wang, Yang Zou
Summary: The study revealed that LASPI plays an important role in the pathogenesis of adenomyosis, with its overexpression enhancing the proliferative, migratory and invasive abilities of EcESCs, potentially related to DNA hypermethylation. Further investigation is needed to explore the detailed molecular mechanisms of LASPI upregulation in promoting cell proliferation, invasion and migration in adenomyosis. LASPI could serve as a prognostic biomarker for adenomyosis.
MOLECULAR HUMAN REPRODUCTION
(2021)
Article
Food Science & Technology
Florencia Chiappini, Leandro Ceballos, Carla Olivares, Juan Ignacio Baston, Noelia Miret, Carolina Pontillo, Lorena Zarate, Jose Javier Singla, Mariana Farina, Gabriela Meresman, Andrea Randi
Summary: This study found that hexachlorobenzene (HCB) exposure can induce changes associated with endometriosis, including increased levels of estrogen receptor α and aromatase protein, decreased progesterone receptor content, and promoted cell migration and invasion. These results reveal the mechanisms by which pesticide exposure may contribute to the development of endometriosis.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Cell Biology
Maidinaimu Abudula, Xiaodan Fan, Jing Zhang, Jiajie Li, Xiaoming Zhou, Yichen Chen
Summary: This study found that exosomal MSN derived from ectopic stromal cells can contribute to endometriosis progression by mediating the construction of a migration-vascularization-inflammation loop in the ectopic environment.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Immunology
Feng Zhou, Fanxuan Zhao, Qianmeng Huang, Xiang Lin, Songying Zhang, Yongdong Dai
Summary: This study suggests that the occurrence of endometriosis may be associated with the interaction between macrophages and endometrial stromal cells, promoting the development of endometriotic lesions by activating the NLRP3 inflammasome.
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2022)
Article
Endocrinology & Metabolism
Zhen Xu, Heng Zhao, Caixin Yue, Lixia Zhang, Muzi Li, Yanbo Du, Na Zhang, Lei Yan
Summary: The STING signaling pathway plays a significant role in the proliferation, invasion, and migration of endometrial stromal cells associated with endometriosis.
GYNECOLOGICAL ENDOCRINOLOGY
(2022)
Article
Cell Biology
Dandan Wang, Yixin Zhang, Liangyi Cui, Qing Yang, Jiao Wang
Summary: LTBP2 plays a critical role in the occurrence and development of endometriosis and could be a potential target for the diagnosis and treatment of the disease.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Lili Dong, Gaiwen Liu, Huiying Xiao
Summary: The DLK1/IGF-2 axis is potentially involved in the pathogenesis of endometriosis, regulating the viability, migration, and adhesion of endometrial stromal cells.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Article
Oncology
Yongjuan Gu, Zhigang Zhou
Summary: The study demonstrated that berberine inhibits proliferation, invasion, and migration of endometriosis cells by downregulating the expression of miR-429, suggesting a potential therapeutic target for the treatment of endometriosis.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Pharmacology & Pharmacy
Jayaraj Ravindran, Hareesh B. Nair, Bokyung Sung, Sandeo Prasad, Rajeshwar R. Tekmal, Bharat B. Aggarwal
BIOCHEMICAL PHARMACOLOGY
(2010)
Review
Pharmacology & Pharmacy
Hareesh B. Nair, Bokyung Sung, Vivek R. Yadav, Ramaswamy Kannappan, Madan M. Chaturvedi, Bharat B. Aggarwal
BIOCHEMICAL PHARMACOLOGY
(2010)
Article
Pharmacology & Pharmacy
Preetha Anand, Hareesh B. Nair, Bokyung Sung, Ajaikumar B. Kunnumakkara, Vivek R. Yadav, Rajeshwar R. Tekmal, Bharat B. Aggarwal
BIOCHEMICAL PHARMACOLOGY
(2010)
Article
Obstetrics & Gynecology
Nicole M. Budrys, Hareesh B. Nair, Ya-Guang Liu, Nameer B. Kirma, Peter A. Binkley, Shantha Kumar, Robert S. Schenken, Rajeshwar Rao Tekmal
FERTILITY AND STERILITY
(2012)
Article
Oncology
Poornachand Veerapaneni, Nameer Kirma, Hareesh B. Nair, Luciano S. Hammes, Kevin L. Hall, Rajeshwar Rao Tekmal
GYNECOLOGIC ONCOLOGY
(2009)
Article
Chemistry, Multidisciplinary
Hareesh B. Nair, Steven Huffman, Poornachand Veerapaneni, Nameer B. Kirma, Peter Binkley, Rao P. Perla, Dean B. Evans, Rajeshwar R. Tekmal
JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
(2011)
Article
Oncology
Shylesh Bhaskaran, Kalarikkal V. Dileep, Sathyaseelan S. Deepa, Chittalakkottu Sadasivan, Mitch Klausner, Naveen K. Krishnegowda, Rajeshwar R. Tekmal, John L. VandeBerg, Hareesh B. Nair
MOLECULAR CANCER THERAPEUTICS
(2013)
Article
Endocrinology & Metabolism
Rajib Rajhans, Hareesh B. Nair, Sujit S. Nair, Valerie Cortez, Kijima Ikuko, Nameer B. Kirma, Dujin Zhou, Alan E. Holden, Darrell W. Brann, Shiuan Chen, Rajeshwar Rao Tekmal, Ratna K. Vadlamudi
MOLECULAR ENDOCRINOLOGY
(2008)
Article
Developmental Biology
Ya-guang Liu, Rajeshwar R. Tekmal, Peter A. Binkley, Hareesh B. Nair, Robert S. Schenken, Nameer B. Kirma
MOLECULAR HUMAN REPRODUCTION
(2009)
Article
Biochemistry & Molecular Biology
C-R Pradeep, W. J. Koestler, M. Lauriola, R. Z. Granit, F. Zhang, J. Jacob-Hirsch, G. Rechavi, H. B. Nair, B. T. Hennessy, A. M. Gonzalez-Angulo, R. R. Tekmal, I. Ben-Porath, G. B. Mills, E. Domany, Y. Yarden
Letter
Oncology
Hareesh B. Nair, Allen Ford, Edward J. Dick, Ralph H. Hill, John L. VandeBerg
PIGMENT CELL & MELANOMA RESEARCH
(2014)
Article
Biochemistry & Molecular Biology
Hareesh B. Nair, Nameer B. Kirma, Manonmani Ganapathy, Ratna K. Vadlamudi, Rajeshwar Rao Tekmal
Article
Biochemistry & Molecular Biology
Klaus Nickisch, Hareesh B. Nair, Narkunan Kesavaram, Baishakhi Das, Robert Garfield, Shao-Qing Shi, Shylesh S. Bhaskaran, Sandra L. Grimm, Dean P. Edwards
Article
Oncology
Hareesh B. Nair, Rao P. Perla, Nameer B. Kirma, Naveen K. Krishnegowda, Manonmani Ganapathy, Rajib Rajhans, Sujit S. Nair, Pothana Saikumar, Ratna K. Vadlamudi, Rajeshwar Rao Tekmal
Article
Oncology
Joseph K. Agyin, Bindu Santhamma, Hareesh B. Nair, Sudipa S. Roy, Rajeshwar R. Tekmal
BREAST CANCER RESEARCH
(2009)