‘Drugs from Bugs’: bacterial effector proteins as promising biological (immune-) therapeutics

IL-8 as Antibody Therapeutic Target in Inflammatory Diseases: Reduction of Clinical Activity in Palmoplantar Pustulosis

(2014) L. Skov et al.   JOURNAL OF IMMUNOLOGY

NleB, a Bacterial Effector with Glycosyltransferase Activity, Targets GAPDH Function to Inhibit NF-κB Activation

(2013) Xiaofei Gao et al.   Cell Host & Microbe

Autonomous translocation and intracellular trafficking of the cell-penetrating and immune-suppressive effector protein YopM

(2013) Julia Scharnert et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Pathogen blocks host death receptor signalling by arginine GlcNAcylation of death domains

(2013) Shan Li et al.   NATURE

A type III effector antagonizes death receptor signalling during bacterial gut infection

(2013) Jaclyn S. Pearson et al.   NATURE

Identification of tissue-specific targeting peptide

(2012) Eunkyoung Jung et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

A type III effector protease NleC from enteropathogenic Escherichia coli targets NF-κB for degradation

(2011) Jaclyn S. Pearson et al.   MOLECULAR MICROBIOLOGY

Cysteine methylation disrupts ubiquitin-chain sensing in NF-κB activation

(2011) Li Zhang et al.   NATURE

IKKβ phosphorylation regulates RPS3 nuclear translocation and NF-κB function during infection with Escherichia coli strain O157:H7

(2011) Fengyi Wan et al.   NATURE IMMUNOLOGY

Delineation of Regions of the Yersinia YopM Protein Required for Interaction with the RSK1 and PRK2 Host Kinases and Their Requirement for Interleukin-10 Production and Virulence

(2010) J. B. McPhee et al.   INFECTION AND IMMUNITY

A newly identified bacterial cell-penetrating peptide that reduces the transcription of pro-inflammatory cytokines

(2010) C. Ruter et al.   JOURNAL OF CELL SCIENCE

The Type III Effectors NleE and NleB from Enteropathogenic E. coli and OspZ from Shigella Block Nuclear Translocation of NF-κB p65

(2010) Hayley J. Newton et al.   PLoS Pathogens

Translocated effectors of Yersinia

(2009) Hiroyuki Matsumoto et al.   CURRENT OPINION IN MICROBIOLOGY

A bacterial E3 ubiquitin ligase IpaH9.8 targets NEMO/IKKγ to dampen the host NF-κB-mediated inflammatory response

(2009) Hiroshi Ashida et al.   NATURE CELL BIOLOGY

Bacterial Effector Binding to Ribosomal Protein S3 Subverts NF-κB Function

(2009) Xiaofei Gao et al.   PLoS Pathogens

Regulation of Expression and Secretion of NleH, a New Non-Locus of Enterocyte Effacement-Encoded Effector in Citrobacter rodentium

(2008) V. A. Garcia-Angulo et al.   JOURNAL OF BACTERIOLOGY

Autoimmune and inflammatory disorders and risk of malignant lymphomas - an update

(2008) K. E. Smedby et al.   JOURNAL OF INTERNAL MEDICINE

Natural killer cell–directed therapies: moving from unexpected results to successful strategies

(2008) Magali Terme et al.   NATURE IMMUNOLOGY

Cell-penetrating peptides as delivery vehicles for biology and medicine

(2008) Kelly M. Stewart et al.   ORGANIC & BIOMOLECULAR CHEMISTRY