Journal
FEMS MICROBIOLOGY LETTERS
Volume 338, Issue 1, Pages 86-94Publisher
OXFORD UNIV PRESS
DOI: 10.1111/1574-6968.12032
Keywords
toxin-antitoxin; Burkholderia pseudomallei; melioidosis; persister cell; antibiotic resistance; expression and screening system
Categories
Funding
- Wellcome Trust [WT085162AIA] Funding Source: Medline
Ask authors/readers for more resources
Type II toxinantitoxin (TA) systems are believed to be widely distributed amongst bacteria although their biological functions are not clear. We have identified eight candidate TA systems in the genome of the human pathogen Burkholderia pseudomallei. Five of these were located in genome islands. Of the candidate toxins, BPSL0175 (RelE1) or BPSS1060 (RelE2) caused growth to cease when expressed in Escherichia coli, whereas expression of BPSS0390 (HicA) or BPSS1584 (HipA) (in an E. coli Delta hipBA background) caused a reduction in the number of culturable bacteria. The cognate antitoxins could restore growth and culturability of cells.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available