Journal
FEMS MICROBIOLOGY LETTERS
Volume 279, Issue 1, Pages 92-102Publisher
OXFORD UNIV PRESS
DOI: 10.1111/j.1574-6968.2007.01013.x
Keywords
dendritic cells; CD11b; CD51; Leishmania donovani; phagocytosis; adhesion
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The protective immune response against the parasite, including the role of dendritic cells (DC) in the course of infection, plays a fundamental role. This study shows that wild-type (WT) Leishmania promastigotes and specifically the phosphoglycans family of virulence-associated antigens inhibit human monocyte-derived dendritic cells (MoDC) maturation and detachment to distinct surfaces. Immature phagocytosis of Leishmania donovani promastigotes by immature MoDC results in the increased expression of CD11b and CD51, and inhibition of cell detachment to distinct surfaces, which was dependent on the presence of phosphoglycans. These findings demonstrate that phosphoglycans of WT L. donovani might also inhibit human DC migration to lymphoid organs.
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