Article
Chemistry, Multidisciplinary
Katarzyna Jastrzebska, Anna Maciaszek, Rafal Dolot, Agnieszka Tomaszewska-Antczak, Barbara Mikolajczyk, Piotr Guga
Summary: This study synthesized and investigated Oxathiaphospholane derivatives of ribonucleosides, and demonstrated that their specific configurations have no correlation with the thermal stability of DNA and RNA duplexes.
Review
Infectious Diseases
Dana Holger, Razieh Kebriaei, Taylor Morrisette, Katherine Lev, Jose Alexander, Michael Rybak
Summary: Pseudomonas aeruginosa is a common pathogen causing healthcare-associated diseases and is highly resistant to many antibiotics, posing challenges in treatment. Bacteriophages, as viruses targeting and infecting bacterial cells, offer promise as an alternative therapy for multidrug-resistant P. aeruginosa infections. Further studies on phage pharmacokinetics and pharmacodynamics are needed to guide successful phage therapy for these infections.
Article
Chemistry, Multidisciplinary
Shi-Jie Hao, Ya-Xuan Zhu, Fu -Gen Wu
Summary: Researchers developed a membrane fusion liposome (MFL) loaded with a small-molecule tyrosine kinase inhibitor (TKI) and doxorubicin (Dox) to achieve tumor cell membrane fusion-mediated drug delivery and enhanced chemotherapy of drug-resistant tumor.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Microbiology
Luke Diorio-Toth, Sidra Irum, Robert F. Potter, Meghan A. Wallace, Muhammad Arslan, Tehmina Munir, Saadia Andleeb, Carey-Ann D. Burnham, Gautam Dantas
Summary: This study used whole-genome sequencing to determine the genotypic mechanisms of beta-lactam resistance in Pseudomonas aeruginosa clinical isolates from three hospitals in Pakistan. The study found that carbapenem resistance was associated with the acquisition of metallo-beta-lactamases or extended-spectrum beta-lactamases and mutations in the porin gene. Furthermore, isolates with multiple resistance mechanisms showed significantly higher levels of imipenem resistance compared to isolates with a single resistance mechanism.
MICROBIOLOGY SPECTRUM
(2022)
Article
Infectious Diseases
James A. Karlowsky, Sibylle H. Lob, Fakhar Siddiqui, Brune Akrich, C. Andrew DeRyke, Katherine Young, Mary R. Motyl, Stephen P. Hawser, Daniel F. Sahm
Summary: The study found that most Pseudomonas aeruginosa isolates in Western Europe (93.3%) were susceptible to ceftolozane/tazobactam, indicating it as an important treatment option for multidrug-resistant infections.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2023)
Article
Infectious Diseases
Pilar Hernandez-Jimenez, Francisco Lopez-Medrano, Mario Fernandez-Ruiz, Jose T. Silva, Laura Corbella, Rafael San-Juan, Maria Ruiz-Ruigomez, Manuel Lizasoain, Isabel Rodriguez-Goncer, Jazmin Diaz-Reganon, Diego Lopez-Mendoza, Esther Viedma, Jose Maria Aguado
Summary: Infections caused by multidrug-resistant Pseudomonas aeruginosa (MDR-PSA) have a poorer prognosis compared to non-MDR-PSA infections. Our score can guide empirical therapy for MDR-PSA when P. aeruginosa is isolated.
JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE
(2022)
Review
Infectious Diseases
Frank Jones, Yanmin Hu, Anthony Coates
Summary: The study found that combination therapies may be more effective than monotherapies, but the clinical studies were limited in number and lacked statistical significance, indicating a need for further research.
Review
Immunology
R. Fredi Langendonk, Daniel R. Neill, Joanne L. Fothergill
Summary: P. aeruginosa, a priority one pathogen according to the WHO, is in urgent need of new drugs due to the emergence of multidrug-resistant strains. Antimicrobial stewardship faces challenges during the COVID-19 pandemic, with increased use of antibiotics and sanitizers likely accelerating the development of resistance. Developing anti-resistance adjuvant therapies targeting multiple resistance mechanisms may offer promise in combating multidrug resistant P. aeruginosa and extending the effectiveness of traditional antimicrobials.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Microbiology
Michael Y. T. Chow, Rachel Yoon Kyung Chang, Mengyu Li, Yuncheng Wang, Yu Lin, Sandra Morales, Andrew J. McLachlan, Elizabeth Kutter, Jian Li, Hak-Kim Chan
Summary: Inhaled bacteriophage therapy shows potential as an alternative to combat MDR Pseudomonas aeruginosa infections. Studies on the PK and PD profiles of phage PEV31 delivered by the pulmonary route in mice demonstrated a potential reduction in MDR bacterial burden through lung delivery.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Infectious Diseases
Elena Sendra, Inmaculada Lopez Montesinos, Alicia Rodriguez-Alarcon, Juan Du, Ana Siverio-Pares, Mar Arenas-Miras, Esperanza Canas-Ruano, Nuria Prim, Xavier Duran-Jorda, Fabiola Blasco-Hernando, Enric Garcia-Alzorriz, Francesc Cots, Olivia Ferrandez, Silvia Gomez-Zorrilla
Summary: This study compared the clinical characteristics, outcomes, and economic differences between complicated urinary tract infections caused by extensively drug-resistant Pseudomonas aeruginosa and extended-spectrum beta-lactamase-producing Klebsiella pneumoniae. The results showed that patients with XDR P. aeruginosa cUTI more frequently received inappropriate empirical therapy, while ESBL-K. pneumoniae cUTI was associated with worse eradication rates, higher recurrence, and higher infection-related readmission. XDR P. aeruginosa cUTI was associated with worse early clinical cures and more antibiotic side effects, but no differences in mortality or hospitalization costs were observed.
Review
Infectious Diseases
Anusha Gauba, Khondaker Miraz Rahman
Summary: Multidrug-resistant Gram-negative bacterial infections pose a serious global healthcare and economic threat. The lack of new therapies and the increasing resistance levels call for urgent research and development of novel targeted therapies. Efforts have been made to combat antibiotic resistance by targeting specific mechanisms, but further research is needed to understand the precise mechanisms and explore narrow-spectrum targeted therapies.
Article
Infectious Diseases
Longyin Zhu, Huan Xu, Youmin Pu, Chunxiao Fu, Qianguang Pan, Hongwen Zhao
Summary: We report a case of pneumocystis jiroveci pneumonia in a kidney transplant recipient. Metagenomics next-generation sequencing (mNGS) and sulfonamide desensitization were used to identify and control the disease, while combined treatment effectively alleviated symptoms of other infections.
INFECTION AND DRUG RESISTANCE
(2023)
Review
Microbiology
Mahmood Al-Orphaly, Hamad Abdel Hadi, Faiha Kamaleldin Eltayeb, Hissa Al-Hail, Bincy Gladson Samuel, Ali A. Sultan, Sini Skariah
Summary: The prevalence, antimicrobial characteristics, and genetic profiles of MDR P. aeruginosa in the MENA region vary significantly among countries, with high prevalence seen in most countries and similarities found between neighboring countries. Isolates from critical care units show high resistance levels, particularly in countries like Saudi Arabia, Egypt, Libya, Syria, and Lebanon, with resistance to cephalosporins, carbapenems, and aminoglycosides. Colistin susceptibility remains high overall, except in countries with high-level antibiotic resistance such as Saudi Arabia, Syria, and Egypt.
Review
Biology
Luca Gregorio Giaccari, Maria Caterina Pace, Maria Beatrice Passavanti, Francesca Gargano, Caterina Aurilio, Pasquale Sansone
Summary: Ceftolozane/tazobactam (C/T) may be a valid therapeutic option for treating multidrug-resistant Pseudomonas aeruginosa infections, with high clinical success rates and good tolerability, making it feasible to use in various comorbidities.
Article
Medicine, General & Internal
Dilshad Ahmed, Hasnain Javed, Wajiha Kanwal, Warda Fatima, Nida Abdul Qadir
Summary: This study aimed to determine the rate of multidrug-resistant (MDR) and extended drug-resistant (XDR) Pseudomonas aeruginosa and to assess the effectiveness of different antimicrobial agents against clinically isolated bacterial samples. The results showed that MDR and XDR Pseudomonas aeruginosa infections were more common among males and the 31-45 age group. Doripenem exhibited the highest sensitivity among carbapenems, while polymyxin B showed the highest activity against multi and extensively drug-resistant strains of Pseudomonas aeruginosa.
ANNALS OF KING EDWARD MEDICAL UNIVERSITY LAHORE PAKISTAN
(2023)
Article
Biochemical Research Methods
Rui Meng, Wen-Ke Cai, Wen-Mang Xu, Qiang Feng, Ping Wang, Yan-hua Huang, Yu-Xin Fan, Tao Zhou, Qin Yang, Zhi-Ran Li, Gong-Hao He
Summary: The study successfully generated endothelial cell-specific knockout mice with deleted HRH2 gene, which provided insights into the role of HRH2 in endothelial cells. The knockout mice were normal, healthy, and fertile, presenting new possibilities for exploring the development and treatment of related diseases.
TRANSGENIC RESEARCH
(2021)
Article
Clinical Neurology
Gui-Xin Zhao, Zheng Zhang, Wen-Ke Cai, Ming-Li Shen, Ping Wang, Gong-Hao He
Summary: This meta-analysis revealed that CYP3A4 rs2242480, CYP3A5 rs776746, and SCN1A rs3812718 polymorphisms are associated with carbamazepine metabolism and resistance in epilepsy patients, while SCN1A rs2298771 polymorphism is not. These findings could potentially impact personalized therapy for epileptic patients.
Article
Medicine, Research & Experimental
Yan-Hua Huang, Sun-Jun Yin, Yuan-Yuan Gong, Zhi-Ran Li, Qin Yang, Yu-Xin Fan, Tao Zhou, Rui Meng, Ping Wang, Gong-Hao He
Summary: The comprehensive meta-analysis confirms a significant association between high PARP1 expression and poor clinical outcomes in various cancers. Additionally, increased PARP1 expression is related to clinicopathological features.
BIOMARKERS IN MEDICINE
(2021)
Article
Clinical Neurology
Yu-Xin Fan, Zheng Zhang, Jing-Ru Meng, Sun-Jun Yin, Ping Wang, Tao Zhou, Yan-Hua Huang, Rui Meng, Gong-Hao He
Summary: This meta-analysis revealed that ABCB1 gene polymorphisms rs1045642 and rs2032582 were associated with carbamazepine metabolism in epilepsy, while rs1128503 was related to carbamazepine resistance. These findings could help in improving personalized therapy for epileptic patients.
Review
Immunology
Yu-Xin Fan, Jiang-Hai Wu, Sun-Jun Yin, Tao Zhou, Yan-Hua Huang, Rui Meng, Ping Wang, Gong-Hao He
Summary: This study investigates the association of FOXP3 single nucleotide polymorphisms (SNPs) with the risk of preeclampsia (PE) through a meta-analysis. The results demonstrate that FOXP3 rs3761548 and rs2232365 SNPs are related to PE susceptibility and may serve as potential biomarkers for predicting PE risk.
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Yan-Hua Huang, Wen-ke Cai, Sun-Jun Yin, Ping Wang, Zhi-Ran Li, Qin Yang, Tao Zhou, Rui Meng, Mei Yang, Yu Guo, Gong-Hao He
Summary: This study found that the use of histamine H2 receptor antagonists (H2RAs) was associated with lower mortality in critically ill patients with heart failure (HF), and ranitidine may be superior to famotidine in reducing mortality of these patients.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Tao Zhou, Kai Qian, Yun-Yun Li, Wen-Ke Cai, Sun-Jun Yin, Ping Wang, Gong-Hao He
Summary: This study systematically investigated the functions and clinical prognostic value of pyroptosis-related genes (PRGs) in acute myeloid leukemia (AML). The results showed that these genes were associated with AML prognosis and could serve as independent predictors. Furthermore, these genes were also associated with the tumor immune microenvironment and drug sensitivity.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Oncology
Man-Li Zhang, Yu-Xin Fan, Rui Meng, Wen-Ke Cai, Sun-Jun Yin, Tao Zhou, Yan-Hua Huang, Ping Wang, Fang-Fang Jiang, Mei Yang, Gong-Hao He
Summary: The umbrella review found that the use of PPIs is associated with an increased risk of certain cancers, including gastric, pancreatic, colorectal, and liver cancer, but is not associated with esophageal cancer. Additionally, PPI use is associated with a decreased risk of breast cancer.
AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS
(2022)
Review
Rheumatology
Ya-Jia Li, Li-Rong Chen, Zhong-Lei Yang, Ping Wang, Fang-Fang Jiang, Yu Guo, Kai Qian, Mei Yang, Sun-Jun Yin, Gong-Hao He
Summary: The network meta-analysis demonstrated that dotinurad is one of the most effective and safe drugs for treating gout or hyperuricemia patients. Verinurad could be considered as an alternative uricosuric therapeutic option to dotinurad.
CLINICAL RHEUMATOLOGY
(2023)
Review
Pharmacology & Pharmacy
Rui Meng, Li-Rong Chen, Man-Li Zhang, Wen-Ke Cai, Sun-Jun Yin, Yu-Xin Fan, Tao Zhou, Yan-Hua Huang, Gong-Hao He
Summary: This study systematically assessed the correlations between the use of histamine H2 receptor antagonists (H2RAs) and the risk of adverse outcomes. The findings confirmed significant associations of H2RA use with pneumonia, peritonitis, necrotizing enterocolitis, Clostridium difficile infection, liver cancer, gastric cancer, and hip fracture diseases. However, no associations were observed with colorectal cancer, melanoma, kidney cancer, lung cancer, or other system diseases.
JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Article
Oncology
Li-Rong Chen, Ya-Jia Li, Zheng Zhang, Ping Wang, Tao Zhou, Kai Qian, Yu-Xin Fan, Yu Guo, Gong-Hao He, Lei Shen
Summary: A meta-analysis on the cardiovascular toxicities of CAR-T cell therapy in cancer patients revealed that arrhythmias, cardiovascular dysfunction, and heart failure were the most common cardiovascular events, highlighting the need for rational and individualized use of CAR-T cells in clinical treatment.
FRONTIERS IN ONCOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Hui Zhao, Dan Nie, Yue Hu, Zhou Chen, Zheng Hou, Mingkai Li, Xiaoyan Xue
Summary: The emergence of antibiotic-resistant bacteria poses a serious public health threat, leading to an urgent need for the discovery of novel antibacterial agents. Phage display technology shows great potential for screening peptides or antibodies with high binding capacities for a wide range of targets. This paper summarizes the recent progress of phage display in the discovery of therapeutic agents, identification of bacterial target protein action sites, and rapid detection of different pathogens, while also discussing several problems that need to be solved for further development and application of this technology in the biomedical field.
Review
Biochemistry & Molecular Biology
Yu-Xin Fan, Li -Rong Chen, Run-Xin Gan, Sun-Jun Yin, Ping Wang, Rui Meng, Yan-Hua Huang, Fang-Fang Jiang, Gong-Hao He
Summary: This meta-analysis found that IL-10 polymorphisms, specifically rs1800896 and rs1800872, were associated with increased risk of acute leukemia.
Article
Pharmacology & Pharmacy
Xue-Sha Zhang, Wen-Ke Cai, Ping Wang, Ran Xu, Sun-Jun Yin, Yan-Hua Huang, Yu Guo, Fang-Fang Jiang, Jian-Mei Pan, Yi-Hua Li, Gong-Hao He
Summary: This study compared the effects of H2RAs and beta-blockers on mortality of critically ill patients with heart failure, finding that H2RAs had a similar mortality-decreasing effect as beta-blockers and that the combination of the two showed improved survival outcomes.
FRONTIERS IN PHARMACOLOGY
(2023)
Correction
Cardiac & Cardiovascular Systems
Yan Hua Huang, Wen Ke Cai, Sun Jun Yin, Ping Wang, Zhi Ran Li, Qin Yang, Tao Zhou, Rui Meng, Mei Yang, Yu Guo, Gong Hao He
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2022)