Journal
FEBS LETTERS
Volume 588, Issue 20, Pages 3703-3712Publisher
WILEY
DOI: 10.1016/j.febslet.2014.08.016
Keywords
miR-204; SIX1; Proliferation; Invasion; Epithelial-to-mesenchymal transition; Non-small cell lung cancer
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The involvement of miR-204 in lung cancer development is unclear. In our study, we analyzed the expression of miR-204 in tumor- and adjacent-tissue samples from 141 patients with non-small cell lung cancer (NSCLC). MiR-204 expression was decreased in tumor samples compared with noncancerous tissue-derived controls. Moreover, miR-204 expression negatively correlated with homeobox protein SIX1 expression, tumor size and metastasis. MiR-204 silencing in miR-204-positive NSCLC cell lines promoted cell invasion and proliferation. Concomitantly, MiR-204 overexpression resulted in reduced cell proliferation and invasion, upregulated E-cadherin and downregulated N-cadherin and Vimentin expression. SIX1 was identified as a potential target of miR-204, and SIX1 silencing partially compromised the invasive and proliferative capacity of miR-204-deficient cells. Thus, miR-204 may be involved in the NSCLC development. (C) 2014 Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies.
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