Journal
FEBS LETTERS
Volume 588, Issue 17, Pages 3160-3169Publisher
WILEY
DOI: 10.1016/j.febslet.2014.05.068
Keywords
Phosphatase 2A; PPP2R5E; miR-23a; Gastric cancer; Tumorigenesis; Apoptosis
Funding
- National Natural Science Foundation of China [91029714, 31270818, 31101000]
- Natural Science Foundation of Tianjin [12JCZDJC25100]
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PPP2R5E belongs to the phosphatase 2A regulatory subunit B family and acts as a tumor suppressor in human cancer. However, the role of PPP2R5E in the tumorigenesis of gastric cancer is unclear. Here, we declare that PPP2R5E is downregulated by miR-23a and induces cell growth inhibition and apoptosis in gastric cancer cells. Furthermore, ASO-miR-23a suppresses tumor growth derived from MGC803 cells in vivo. PPP2R5E is identified as a new target of miR-23a. Moreover, overexpression of PPP2R5E reversed the negative effects of miR-23a. We highlight the significance of miR-23a and PPP2R5E in the proliferation and apoptosis of gastric cancer cells. (C) 2014 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
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