Anti-cancer drug KP1019 modulates epigenetics and induces DNA damage response inSaccharomyces cerevisiae

An ebselen like catalyst with enhanced GPx activity via a selenol intermediate

(2014) Shah Jaimin Balkrishna et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Ebselen induces reactive oxygen species (ROS)-mediated cytotoxicity in Saccharomyces cerevisiae with inhibition of glutamate dehydrogenase being a target

(2014) Gajendra Kumar Azad et al.   FEBS Open Bio

Mad1 mediates hypoxia-induced doxorubicin resistance in colon cancer cells by inhibiting mitochondrial function

(2013) Kumsun Cho et al.   FREE RADICAL BIOLOGY AND MEDICINE

Cigarette Smoke Component Acrolein Modulates Chromatin Assembly by Inhibiting Histone Acetylation

(2013) Danqi Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Depletion of Cellular Iron by Curcumin Leads to Alteration in Histone Acetylation and Degradation of Sml1p in Saccharomyces cerevisiae

(2013) Gajendra Kumar Azad et al.   PLoS One

Sen1p Contributes to Genomic Integrity by Regulating Expression of Ribonucleotide Reductase 1 (RNR1) in Saccharomyces cerevisiae

(2013) Upendarrao Golla et al.   PLoS One

Drug-induced histone eviction from open chromatin contributes to the chemotherapeutic effects of doxorubicin

(2013) Baoxu Pang et al.   Nature Communications

Identification of a novel histone H3 specific protease activity in nuclei of chicken liver

(2012) Papita Mandal et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Distinct cellular fates for KP1019 and NAMI-A determined by X-ray fluorescence imaging of single cells

(2012) Jade B. Aitken et al.   Metallomics

Mutagenesis of pairwise combinations of histone amino-terminal tails reveals functional redundancy in budding yeast

(2012) J.-A. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multifunctional Ebselen drug functions through the activation of DNA damage response and alterations in nuclear proteins

(2011) Gajendra K. Azad et al.   BIOCHEMICAL PHARMACOLOGY

A Ruthenium Antimetastasis Agent Forms Specific Histone Protein Adducts in the Nucleosome Core

(2011) Bin Wu et al.   CHEMISTRY-A EUROPEAN JOURNAL

Transcriptional Regulation by Asf1

(2010) Laura V. Minard et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Intracellular protein binding patterns of the anticancer ruthenium drugs KP1019 and KP1339

(2010) Petra Heffeter et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

The ribonucleotide reductase inhibitor, Sml1, is sequentially phosphorylated, ubiquitylated and degraded in response to DNA damage

(2010) Bethany L. Andreson et al.   NUCLEIC ACIDS RESEARCH

Analysis of Saccharomyces cerevisiae histone H3 mutants reveals the role of the αN helix in nucleosome function

(2008) Ja-Hwan Seol et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Acetylation of Histone H3 Lysine 56 Regulates Replication-Coupled Nucleosome Assembly

(2008) Qing Li et al.   CELL

KP1019, A New Redox-Active Anticancer Agent - Preclinical Development and Results of a Clinical Phase I Study in Tumor Patients

(2008) Christian G. Hartinger et al.   CHEMISTRY & BIODIVERSITY

Resistance against novel anticancer metal compounds: Differences and similarities

(2008) P HEFFETER et al.   DRUG RESISTANCE UPDATES

Anthracycline Cardiotoxicity: From Bench to Bedside

(2008) Luca Gianni et al.   JOURNAL OF CLINICAL ONCOLOGY

Transcription-coupled DNA repair: two decades of progress and surprises

(2008) Philip C. Hanawalt et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY