Article
Medicine, General & Internal
Tyler S. Saunders, Natalie Jenkins, Kaj Blennow, Craig Ritchie, Graciela Muniz-Terrera
Summary: The relationship between APOE status and CSF p-tau may be mediated by the interaction between sex and cerebrospinal fluid Al3. These findings suggest that tau accumulation may be independent of Al3 in females, but not in males.
Article
Clinical Neurology
Young Ju Kim, Alice Hahn, Yu Hyun Park, Duk L. Na, Juhee Chin, Sang Won Seo
Summary: This study developed a composite score that can sensitively detect the amyloid-beta (A beta)-related cognitive trajectory of preclinical AD using Korean data. The score may contribute to reduction in time and financial burden when monitoring A beta-related cognitive decline and therapeutic efficacy of the disease-modifying agents specifically targeting A beta in secondary prevention trials.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Multidisciplinary Sciences
Gesa Fee Komar, Laura Mieth, Axel Buchner, Raoul Bell
Summary: The cognitive mechanisms underlying the animacy effect on free recall have not been determined. According to the attentional-prioritization account, animate words are better recalled because they receive more attention during encoding. This study aimed to investigate whether list composition or pair composition can modulate the animacy effect. The results showed that the animacy effect was equally large in mixed and pure lists or pairs, contradicting the attentional-prioritization account.
SCIENTIFIC REPORTS
(2023)
Article
Neurosciences
Jenna N. Adams, Soyun Kim, Batool Rizvi, Mithra Sathishkumar, Lisa Taylor, Alyssa L. Harris, Abanoub Mikhail, David B. Keator, Liv McMillan, Michael A. Yassa
Summary: This study examined the relationship between functional connectivity (FC) within the entorhinal-hippocampal circuit, mnemonic discrimination, and amyloid-P (AP) pathology. The findings suggest that low object mnemonic discrimination performance is associated with increased FC between the anterior-lateral entorhinal cortex (alEC) and dentate gyrus (DG)/CA3, which is related to AP pathology and decreased entorhinal cortex volume. In contrast, spatial mnemonic discrimination is not associated with altered FC.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Medicine, General & Internal
Katarzyna Wachowska, Janusz Szemraj, Janusz Smigielski, Piotr Galecki
Summary: This study found that levels of IL-1 and IL-6 in the serum were increased in depressed patients, and their episodic memory was impaired. However, these two dysfunctions do not seem to covary in the present study.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Behavioral Sciences
Philippe Blonde, Jean-Charles Girardeau, Marco Sperduti, Pascale Piolino
Summary: In the field of cognitive neuroscience, mind wandering has gained increasing interest in the past two decades. However, its effect on episodic memory encoding has only recently been studied and there is currently no systematic synthesis on this topic. This systematic review examined the literature on mind wandering and episodic memory, finding that stimulus-independent mind wandering negatively affects the encoding of both words and audio-visual stimuli. However, some studies suggest a potential positive effect of stimulus-dependent mind wandering on episodic memory encoding. Theoretical explanations, limitations of existing research, and possible future research directions are discussed.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Article
Geriatrics & Gerontology
Geoffroy Gagliardi, Patrizia Vannini
Summary: This study investigates the mechanisms of awareness loss in Alzheimer's Disease, and finds that dysfunction in episodic memory is primarily responsible for the effect of amyloid on awareness.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Medicine, Research & Experimental
Luka Rejc, Vanessa Gomez-Vallejo, Ana Joya, Oscar Moreno, Ander Egimendia, Pilar Castellnou, Xabier Rios-Anglada, Unai Cossio, Zurine Baz, Rossana Passannante, Ignacio Tobalina-Larrea, Pedro Ramos-Cabrer, Albert Giralt, Magdalena Sastre, Estibaliz Capetillo-Zarate, Urban Kosak, Damijan Knez, Stanislav Gobec, Mariel Marder, Abraham Martin, Jordi Llop
Summary: The study investigated the potential of butyrylcholinesterase (BChE) as an early biomarker for Alzheimer's disease (AD) by analyzing its abundance in the brains of AD model animals and controls. The results suggested that BChE accumulation in the brain is associated with amyloid beta deposition, indicating its promising role as an early biomarker for AD.
Article
Clinical Neurology
HyunChul Youn, Won Seok William Hyung, Junhyung Kim, Eun Seong Lee, Jae Seon Eo, Cheol E. Han, Changsu Han, Seung-Hyun Kim, Hyun-Ghang Jeong
Summary: This study investigated the 1-year changes in neuropsychological test results in older adults with late-life depression and mild cognitive impairment, based on the presence or absence of brain amyloidopathy. The findings showed differences in the extent of change depending on the severity of depressive symptoms and amyloidopathy status. Clinicians should consider exploring neuropathology when assessing older adults with depression and cognitive impairment.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Geriatrics & Gerontology
Noora Lindgren, Jaakko Kaprio, Tomi Karjalainen, Laura Ekblad, Semi Helin, Mira Karrasch, Jarmo Teuho, Juha O. Rinne, Eero Vuoksimaa
Summary: In twins, there is an association between episodic memory and cortical amyloid pathology, and this relationship is not confounded by genetic effects.
NEUROBIOLOGY OF AGING
(2021)
Article
Medicine, General & Internal
Eun-Young Lee
Summary: This study investigated the mechanisms underlying memory deficits in Parkinson's disease (PD) and their relationship with brain structural metrics. The findings showed that PD patients had lower memory capacity scores compared to controls in both memory experiments. Additionally, PD patients exhibited reduced cortical thickness in the left superior temporal gyrus, which was associated with lower memory scores.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Psychology, Multidisciplinary
Karine Lebreton, Joelle Malvy, Laetitia Bon, Alice Hamel-Desbrueres, Geoffrey Marcaggi, Patrice Clochon, Fabian Guenole, Edgar Moussaoui, Dermot M. Bowler, Frederique Bonnet-Brilhault, Francis Eustache, Jean-Marc Baleyte, Berengere Guillery-Girard
Summary: This study found that individuals with Autism Spectrum Disorder (ASD) tend to process information with a bias towards local details, impacting their memory performance in recognition tasks and leading to confusion between explicit memories that share common details.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Geriatrics & Gerontology
Nicole S. McKay, Aylin Dincer, Vidushri Mehrotra, Andrew J. Aschenbrenner, David Balota, Russ C. Hornbeck, Jason Hassenstab, John C. Morris, Tammie L. S. Benzinger, Brian A. Gordon
Summary: This study found that many older adults possess Alzheimer's disease (AD) pathologies such as beta-amyloid (A beta) deposition, despite being asymptomatic. The presence of preclinical AD pathology was found to alter the behavior-structure relationship observed in later life. The results suggest that preclinical AD has a significant impact on cognitive aging in a cognitively normal adult population.
NEUROBIOLOGY OF AGING
(2022)
Article
Neuroimaging
Carlos Platero, M. Carmen Tobar
Summary: This study aimed to develop predictive models using longitudinal data from MRI-based markers and neuropsychological tests for predicting conversion from MCI to AD. The models achieved a 77% accuracy at baseline (AUC = 0.855), and improved to 84% accuracy as more visits were available (AUC = 0.912).
BRAIN IMAGING AND BEHAVIOR
(2021)
Article
Geriatrics & Gerontology
Binyin Li, Miao Zhang, Ikbeom Jang, Guanyu Ye, Liche Zhou, Guiying He, Xiaozhu Lin, Hongping Meng, Xinyun Huang, Wangxi Hai, Shengdi Chen, Biao Li, Jun Liu
Summary: In early stages of Alzheimer's disease (AD), patients exhibit decreased connectivity in specific networks during the memory retrieval phase, with impaired functional connectivity mediating the adverse effect of beta-amyloid on memory performance. These findings help elucidate the role of cortical beta-amyloid (A beta) in memory performance in AD.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Clinical Neurology
Jessica Nicosia, Andrew J. Aschenbrenner, David A. Balota, Martin J. Sliwinski, Marisol Tahan, Sarah Adams, Sarah S. Stout, Hannah Wilks, Brian A. Gordon, Tammie L. S. Benzinger, Anne M. Fagan, Chengjie Xiong, Randall J. Bateman, John C. Morris, Jason Hassenstab
Summary: This study confirms the reliability and validity of the ARC smartphone application as a feasible tool for assessing cognitive changes associated with early stages of Alzheimer's disease in older adults. The ARC tasks are reliable and correlated with conventional cognitive measures and AD biomarker burden. The intensive 7-day cycle of ARC testing was feasible and well tolerated by older adult participants, receiving favorable ratings.
JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY
(2023)
Article
Clinical Neurology
Pratishtha Chatterjee, Lisa Vermunt, Brian A. Gordon, Steve Pedrini, Lynn Boonkamp, Nicola J. Armstrong, Chengjie Xiong, Abhay K. Singh, Yan Li, Hamid R. Sohrabi, Kevin Taddei, Mark Molloy, Tammie L. S. Benzinger, John C. Morris, Celeste Karch, Sarah Berman, Jasmeer Chhatwal, Carlos Cruchaga, Neill R. Graff-Radford, Gregory S. Day, Martin Farlow, Nick Fox, Alison Goate, Jason Hassenstab, Jae-Hong Lee, Johannes Levin, Eric McDade, Hiroshi Mori, Richard Perrin, Raquel Sanchez-Valle, Peter R. Schofield, Allan Levey, Mathias Jucker, Colin L. Masters, Anne M. Fagan, Randall J. Bateman, Ralph N. Martins, Charlotte Teunissen
Summary: This study found that plasma GFAP levels increase a decade before symptom onset in AD and are associated with Aβ load, neurodegeneration, and cognitive decline.
ALZHEIMERS & DEMENTIA
(2023)
Article
Clinical Neurology
Chengjie Xiong, Lena M. McCue, Virginia Buckles, Elizabeth Grant, Folasade Agboola, Dean Coble, Randall J. Bateman, Anne M. Fagan, Tammie L. S. Benzinger, Jason Hassenstab, Suzanne E. Schindler, Eric McDade, Krista Moulder, Brian A. Gordon, Carlos Cruchaga, Gregory S. Day, Takeshi Ikeuchi, Kazushi Suzuki, Ricardo F. Allegri, Jonathan Voeglein, Johannes Levin, John C. Morris
Summary: This study compared biomarkers of late-onset Alzheimer's disease (LOAD) and autosomal dominant AD (ADAD). The results showed that at baseline, ADAD mutation carriers (MCs) had lower CSF A beta 42 levels and higher levels of total and phosphorylated tau-181, and PiB uptake compared to LOAD participants with a positive family history (FH+). Longitudinally, MCs had a similar increase in PiB uptake to FH+, but a much faster decline in hippocampal volume, and were the only group showing cognitive decline.
ALZHEIMERS & DEMENTIA
(2023)
Letter
Clinical Neurology
P. M. Cogswell, C. R. Jack Jr, J. A. Barakos, F. Barkhof, T. S. Benzinger, C. A. Raji, T. Y. Poussaint, V. K. Ramanan, C. T. Whitlow
AMERICAN JOURNAL OF NEURORADIOLOGY
(2023)
Article
Clinical Neurology
Julie K. Wisch, Omar H. Butt, Brian A. Gordon, Suzanne E. Schindler, Anne M. Fagan, Rachel L. Henson, Chengran Yang, Anna H. Boerwinkle, Tammie L. S. Benzinger, David M. Holtzman, John C. Morris, Carlos Cruchaga, Beau M. Ances
Summary: Heterogeneity in progression to Alzheimer's disease poses challenges for prognosis and clinical trials. By analyzing CSF proteomics, researchers identified early differences in biomarkers and assessed patterns of preclinical AD development. These findings have important implications for participant selection and potential therapies in clinical trials.
Article
Clinical Neurology
Ganesh M. Babulal, Ling Chen, David B. Carr, Ann M. Johnson, Joshua S. Shimony, Jason Doherty, Samantha Murphy, Alexis Walker, Hailee Domash, Russ Hornbeck, Sarah Keefe, Shaney Flores, Cyrus A. Raji, John C. Morris, Beau M. Ances, Tammie L. S. Benzinger
Summary: This study found that older drivers with mild or moderate cortical atrophy and aging-related changes experienced a decrease in the number of monthly trips, particularly within a one-to-five-mile range from their residence, over a two-and-a-half-year period. Drivers with cerebral small vessel disease (CSVD) showed a larger reduction in daily driving behaviors compared to those without CSVD, indicating it as an early neurobehavioral marker for functional decline. The findings suggest that magnetic resonance imaging can be used to identify high-risk elderly drivers to ensure driving safety and community mobility.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2023)
Article
Clinical Neurology
Jingqin Luo, Yinjiao Ma, Folasade Jane Agboola, Elizabeth C. Grant, John Morris, Eric M. McDade, Anne Fagan, Tammie L. S. Benzinger, Jason J. Hassenstab, Randall J. Bateman, Richard A. Perrin, Brian Gordon, Manu F. Goyal, Jeremy Strain, Igor S. Yakushev, Gregory Day, Chengjie Xiong
Summary: White matter hyperintensities (WMH) are correlated with Alzheimer disease (AD) biomarkers and modulate AD pathogenesis. This study analyzed the longitudinal data of WMH volume and established AD biomarkers in cognitively normal individuals. The results showed that longitudinal increases in WMH volume were associated with changes in PET amyloid uptake, MRI structural outcomes, and cognition. The inflection point of baseline age in WMH volume was identified at 60.46 years.
Article
Cell Biology
Aura L. Ferreiro, JooHee Choi, Jian Ryou, Erin P. Newcomer, Regina Thompson, Rebecca M. Bollinger, Carla Hall-Moore, I. Malick Ndao, Laurie Sax, Tammie L. S. Benzinger, Susan L. Stark, David M. Holtzman, Anne M. Fagan, Suzanne E. Schindler, Carlos Cruchaga, Omar H. Butt, John C. Morris, Phillip I. Tarr, Beau M. Ances, Gautam Dantas
Summary: The gut microbiome of symptomatic patients with Alzheimer's disease (AD) has an altered composition compared to healthy individuals. However, little is known about changes in the gut microbiome before the onset of symptomatic AD. In this study, researchers compared the gut microbiome of cognitively normal individuals with and without biomarker evidence of early preclinical AD. They found distinct differences in the gut microbial composition and identified specific bacterial taxa associated with preclinical AD. These findings may improve our understanding of AD and help identify gut-derived markers of AD risk.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Article
Cell Biology
Nicolas R. Barthelemy, Benjamin Saef, Yan Li, Brian A. Gordon, Yingxin He, Kanta Horie, Erik Stomrud, Gemma Salvado, Shorena Janelidze, Chihiro Sato, Vitaliy Ovod, Rachel L. Henson, Anne M. Fagan, Tammie L. S. Benzinger, Chengjie Xiong, John C. Morris, Oskar Hansson, Randall J. Bateman, Suzanne E. Schindler
Summary: CSF tau phosphorylation at T217 and T205 sites is a better marker for Alzheimer's disease pathology than current tests.
Article
Chemistry, Medicinal
Lin Qiu, Hao Jiang, Charles Zhou, Jinzhi Wang, Yanbo Yu, Haiyang Zhao, Tianyu Huang, Robert Gropler, Joel S. Perlmutter, Tammie L. S. Benzinger, Zhude Tu
Summary: This study reported the design, synthesis, and evaluation of novel F-18 S1PR1 radioligands. Compound 6h showed high selectivity and potency for S1PR1 and exhibited favorable brain washout pharmacokinetics in PET study. [18F]6h is a promising radioligand for imaging S1PR1 and worthy of further clinical investigation in brain disorders.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Cell Biology
Jinbin Xu, Huifangjie L. Farsad, Yiran Hou, Kia Barclay, Ben Anthony Lopez, Shinnosuke Yamada, Ibrahim Olabayode Saliu, Yiming Shi, William C. Knight, Randall J. Bateman, Tammie L. S. Benzinger, Jason J. Yi, Qingyun Li, Ting Wang, Joel S. Perlmutter, John C. Morris, Guoyan Zhao
Summary: Zhao et al. discovered evolutionarily conserved astrocyte and microglia subpopulations shared across multiple brain regions, revealing similarities and differences in AD and PD glia and regional variance linked to AD pathology and neurodegeneration. Their analysis identified commonalities between AD and PD astrocytes and unique transcriptomic changes in microglia for each disorder. They also delineated undescribed subpopulations of medium spiny neurons (MSNs) and provided neuronal transcriptomic profiles suggesting disease-specific changes and selective vulnerability.
Article
Clinical Neurology
Julie K. Wisch, Brian A. Gordon, Anna H. Boerwinkle, Patrick H. Luckett, James G. Bollinger, Vitaliy Ovod, Yan Li, Rachel L. Henson, Tim West, Mathew R. Meyer, Kristopher M. Kirmess, Tammie L. S. Benzinger, Anne M. Fagan, John C. Morris, Randall J. Bateman, Beau M. Ances, Suzanne E. Schindler
Summary: This study investigated whether cerebrospinal fluid (CSF) and plasma levels of amyloid beta (A13)42/A1340 could predict continuous values for amyloid positron emission tomography (PET) burden. The results showed that CSF A1342/A1340 predicted a wider range of amyloid plaque burden and may be useful in staging Alzheimer's disease (AD).
ALZHEIMER'S & DEMENTIA: DIAGNOSIS, ASSESSMENT & DISEASE MONITORING
(2023)
Article
Clinical Neurology
Anna H. Boerwinkle, Brian A. Gordon, Julie Wisch, Shaney Flores, Rachel L. Henson, Omar H. Butt, Nicole McKay, Charles D. Chen, Tammie L. S. Benzinger, Anne M. Fagan, Benjamin L. Handen, Bradley T. Christian, Elizabeth Head, Mark Mapstone, Michael S. Rafii, Sid O'Bryant, Florence Lai, H. Diana Rosas, Joseph H. Lee, Wayne Silverman, Adam M. Brickman, Jasmeer P. Chhatwal, Carlos Cruchaga, Richard J. Perrin, Chengjie Xiong, Jason Hassenstab, Eric McDade, Randall J. Bateman, Beau M. Ances
Summary: Studying the timing and spatial distribution of amyloid accumulation in individuals with autosomal dominant Alzheimer's disease and Down syndrome can provide important insights into the early pathogenesis of Alzheimer's disease.
Article
Psychology, Developmental
Andrew J. Aschenbrenner, Joshua J. Jackson
Summary: Increased variability in cognitive scores, mood or personality traits may be indicative of underlying neurological disorders. Younger adults have higher variability in attention, agreeableness, openness and conscientiousness compared to older adults. Older adults and participants with cognitive impairment show increased variability in attention, openness and conscientiousness. Healthy aging leads to greater stability in personality traits over short intervals, which is not redundant with increased stability in cognitive scores.
AGING NEUROPSYCHOLOGY AND COGNITION
(2023)
Article
Psychology, Mathematical
Jessica Nicosia, Benjamin Wang, Andrew J. Aschenbrenner, Martin J. Sliwinski, Scott T. Yabiku, Nelson A. Roque, Laura T. Germine, Randall J. Bateman, John C. Morris, Jason Hassenstab
Summary: Studies using remote cognitive testing need to decide whether to allow participants to use their own devices or provide study-specific devices. BYOD studies offer advantages but lack control over device performance, which could affect results. This study found significant variations in display and touch latencies among different smartphones, highlighting the need to account for these differences.
BEHAVIOR RESEARCH METHODS
(2023)