Journal
FEBS LETTERS
Volume 588, Issue 9, Pages 1644-1651Publisher
WILEY
DOI: 10.1016/j.febslet.2014.03.002
Keywords
REarranged during Transfection proto-oncogene; MiR-129-5p; Cell growth; Cell apoptosis; Cell migration; Medullary thyroid carcinoma
Funding
- National Natural Science Foundation of China [81201281]
- Natural Science Foundation of Hebei Province of China [C2012401037, H2013209180]
- project of Science and Technology from Government of Tangshan City of Hebei Province [12140209A-4]
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Dysregulation of the REarranged during Transfection proto-oncogene (RET) pathway and microRNA (miRNAs) are crucial for the development of medullary thyroid carcinomas (MTC). Here we demonstrate that miR-129-5p is down-regulated in MTC tissues and cell lines and inhibits RET expression by directly binding its 30 untranslated regions. Ectopic expression of miR-129-5p significantly decreases cell growth, induces apoptosis and suppresses migration ability in MTC cells through decreasing the phosphorylated AKT, thus functioning as a tumor suppressor. These findings give new clues for understanding MTC carcinogenesis and may help in developing a therapeutic approach for the treatment of RET-activated MTC. (C) 2014 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
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