Journal
FEBS LETTERS
Volume 588, Issue 23, Pages 4390-4397Publisher
WILEY
DOI: 10.1016/j.febslet.2014.10.008
Keywords
Muscle-specific RING finger family; Novel MuRF: MuRF4; Striated muscle; E3-ubiquitin ligase; Evolution; Retrotransposition
Funding
- Marine Alliance for Science and Technology for Scotland [VF20]
- University of Aberdeen
- FONDAP project - CONICYT-Chile [15110027]
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Muscle-specific RING finger (MuRF) proteins are E3-ubiquitin ligases and key regulators of muscle growth and turnover. Here, using a range of phylogenomic approaches, we established the complete-definitive MuRF family of vertebrates. Adding to recognized MuRF1, 2 and 3, we describe a novel family member, hereafter MuRF4, which was independently lost during placental mammal and bird evolution, but is otherwise conserved. MuRF4 transcripts were expressed in heart and skeletal muscles of zebrafish, but were barely detectable in striated muscles of adult anole lizards. We also demonstrate that MuRF1 underwent retrotransposition in the teleost fish ancestor, before the retrogene fully replaced the original gene and muscle-specific function. (C) 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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