Review
Biotechnology & Applied Microbiology
Dibyendu Ghosh, M. Malavika, Supriya Chakraborty
Summary: Plant viruses have devastating impact on global agriculture, especially in cases of synergistic infections. Despite plants having a robust antiviral immune reaction, viruses counter with viral suppressors of RNA silencing.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2021)
Article
Multidisciplinary Sciences
Xin Tong, Jia-Jia Zhao, Ya-Lan Feng, Jing-Ze Zou, Jian Ye, Junfeng Liu, Chenggui Han, Dawei Li, Xian-Bing Wang
Summary: Symptom recovery is achieved through a balanced arms race between viruses and plants. A small peptide called VISP1 can mediate the autophagic degradation of viral silencing suppressors, thus maintaining the balance between virus pathogenicity and plant immunity.
NATURE COMMUNICATIONS
(2023)
Review
Biochemistry & Molecular Biology
Wan -Xiang Li, Shou-Wei Ding
Summary: The antiviral defense directed by the RNAi pathway employs distinct specificity and effector mechanisms compared with other immune responses. The specificity of antiviral RNAi is programmed by siRNAs processed from virus-derived double-stranded RNA by Dicer endonuclease. Argonaute-containing RNA-induced silencing complex loaded with the viral siRNAs acts as the effector to mediate specific virus clearance by RNAi. Recent studies have provided evidence for the production and antiviral function of virus-derived siRNAs in both undifferentiated and differentiated mammalian cells infected with a range of RNA viruses when the cognate virus-encoded suppressor of RNAi (VSR) is rendered nonfunctional. In this review, we discuss the function, mechanism, and evolutionary origin of the validated mammalian VSRs and cell culture assays for their identification.
TRENDS IN BIOCHEMICAL SCIENCES
(2022)
Article
Microbiology
Yaqin Wang, Hui Liu, Zhanqi Wang, Yushuang Guo, Tao Hu, Xueping Zhou
Summary: This study found that the P25 and P37 proteins of FLRaV play important roles in overcoming host RNA silencing and aggravating the symptoms and titer of virus infection, providing key insights into the molecular mechanisms underlying FLRaV infection.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Plant Sciences
Florence Jay, Florian Brioudes, Olivier Voinnet
Summary: Transient transgenic expression is a useful tool for pharming and protein studies in plants. However, post-transcriptional gene silencing (PTGS) impedes gene expression during 'agro-infiltration'. Co-expression of the tombusvirus-encoded P19 protein can suppress PTGS and enhance transient gene expression. This study investigates the mechanisms and limitations of the P19 system, providing insights for its optimization and application.
Review
Biochemistry & Molecular Biology
Courtney F. Jungers, Sergej Djuranovic
Summary: This review summarizes our current knowledge on gene expression regulation through interactions of miRNAs and RBPs.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Robert Pertermann, Ralph Peter Golbik, Selvaraj Tamilarasan, Torsten Gursinsky, Selma Gago-Zachert, Vitantonio Pantaleo, Iris Thondorf, Sven-Erik Behrens
Summary: Plant viruses can produce suppressor proteins that inhibit RNA silencing, a mechanism of antiviral plant immunity. These proteins can bind to virus-derived siRNAs and miRNAs, influencing cellular gene expression. The study found that a specific viral suppressor protein, p19, can bind to different miRNAs with varying affinities due to specific features in the RNA and protein molecules. These findings provide important insights into the efficiency and adaptability of the plant antiviral immune response.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Letter
Plant Sciences
Florian Brioudes, Florence Jay, Olivier Voinnet
Summary: This comment discusses the study by Garnelo Gomez et al. (2021) which reveals that the viral silencing suppressor P19 interacts with receptor-like kinases BAM1 and BAM2 to suppress the cell-to-cell movement of RNA silencing, independent of its ability to bind sRNA.
Article
Plant Sciences
Ying Zhai, Anirban Roy, Hao Peng, Daniel L. Mullendore, Gurpreet Kaur, Bikash Mandal, Sunil Kumar Mukherjee, Hanu R. Pappu
Summary: This study identifies four silencing suppressors encoded by Croton yellow vein mosaic virus (CYVMV) and its cognate betasatellite, and investigates their subcellular localizations, interaction behavior, and roles in symptom induction and intercellular virus movement.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Biochemical Research Methods
Song Zhang, Kuerbannisha Amahong, Chenyang Zhang, Fengcheng Li, Jianqing Gao, Yunqing Qiu, Feng Zhu
Summary: This study demonstrates that the genomic RNA of SARS-CoV-2 can absorb host miRNAs that regulate immune-related genes, suggesting that this may be a crucial mechanism for the virus to survive and develop in the host. By analyzing miRNA datasets and identifying enriched immune-related pathways and protein-protein interactions, the study reveals an imbalance in the host immune response caused by the absorption of SARS-CoV-2 to host miRNAs, with implications for infection and pathogenesis. Additionally, the study finds that the absorption of host miRNAs by SARS-CoV-2 may contribute to the increased infectivity and pathogenicity of certain mutant strains.
BRIEFINGS IN BIOINFORMATICS
(2022)
Review
Genetics & Heredity
Lili Jiang, Zunhe Du, Guizhi Zhang, Teng Wang, Guanghui Jin
Summary: This article introduces the mechanisms and progress of using RNA interference technology to enhance potato's resistance to viruses, and discusses the challenges in overcoming RNAi.
Article
Virology
Zena Cai, Ping Fu, Lihua Xu, Li Deng, Yousong Peng
Summary: Virus-encoded small RNAs (vsRNAs) play an important role in viral infections. This study systematically characterized and provided a resource of 19,734 high-confidence vsRNAs, including 2,746 microRNAs (miRNAs), from 64 viral species. Plant viruses exhibited a larger and higher expression level of vsRNAs compared to animal viruses. Additionally, vsRNAs showed specificity in their expression patterns among different strains of a virus, different hosts, cells, or tissues infected by the same virus. This study enhances our understanding of vsRNA diversity and complexity, and provides a valuable resource for further vsRNA studies.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Cell Biology
Tian-Jing Yang, Mu-Di Yao, Ya-Nan Sun, Xiu-Miao Li, Qin Jiang, Biao Yan
Summary: In this study, IPW was found to play a role in the progression of choroidal neovascularization (CNV) and could be a potential target for the treatment of neovascular ocular diseases. Silencing IPW led to reduced CNV formation and altered endothelial cell angiogenic phenotypes through upregulation of miR-370. These findings suggest that IPW silencing may be a promising therapeutic strategy for neovascular ocular diseases.
Review
Cell Biology
Carlos Gorbea, Abdalla Elhakiem, Demian Cazalla
Summary: Just like host cells, viruses also express different classes of noncoding RNAs (ncRNAs) to control the cellular environment. These viral ncRNAs have diverse functions, including regulating viral replication, latency/reactivation decision, immune evasion, and cellular transformation. Studying the ncRNAs expressed by adenoviruses and herpesviruses has provided insights into RNA-based mechanisms in host cells.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2023)
Article
Behavioral Sciences
James S. Brown Jr
Summary: The risk of cancer in schizophrenia has been debated, with confounders such as smoking and antipsychotic medications. In this study, the author compared schizophrenia with cancer and found that both tumor-suppressive and tumor-promoting characteristics exist in schizophrenia. Additionally, schizophrenia shares more oncogenic similarity with asbestos-related lung cancer and mesothelioma.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Article
Biochemistry & Molecular Biology
Dana C. Danielson, Roxana Filip, Megan H. Powdrill, Shifawn O'Hara, John P. Pezacki
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2015)
Article
Medicine, Research & Experimental
Dana C. Danielson, Natalie Sachrajda, Wei Wang, Roxana Filip, John Paul Pezacki
MOLECULAR THERAPY-NUCLEIC ACIDS
(2016)
Article
Biochemistry & Molecular Biology
Jenny Cheng, Dana C. Danielson, Neda Nasheri, Ragunath Singaravelu, John Paul Pezacki
Article
Chemistry, Multidisciplinary
Craig S. McKay, Jessie A. Blake, Jenny Cheng, Dana C. Danielson, John Paul Pezacki
CHEMICAL COMMUNICATIONS
(2011)
Article
Chemistry, Multidisciplinary
David C. Kennedy, Craig S. McKay, Marc C. B. Legault, Dana C. Danielson, Jessie A. Blake, Adrian F. Pegoraro, Albert Stolow, Zoltan Mester, John Paul Pezacki
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2011)
Review
Biochemistry & Molecular Biology
John Paul Pezacki, Jessie A. Blake, Dana C. Danielson, David C. Kennedy, Rodney K. Lyn, Ragunath Singaravelu
NATURE CHEMICAL BIOLOGY
(2011)
Editorial Material
Biochemistry & Molecular Biology
Dana V. Foss, Ross C. Wilson
TRENDS IN MOLECULAR MEDICINE
(2018)
Article
Biochemical Research Methods
Noreen Ahmed, Joanna Frderique De Graaf, Nadine Ahmed, Dana V. Foss, Julie Delcorde, Peter G. Schultz, John Paul Pezacki
BIOCONJUGATE CHEMISTRY
(2018)
Review
Hematology
Dana V. Foss, Megan L. Hochstrasser, Ross C. Wilson
Article
Biochemistry & Molecular Biology
Dana V. Foss, Nicole T. Schirle, Ian J. MacRae, John Paul Pezacki
Article
Biochemistry & Molecular Biology
Noreen Ahmed, Dana Foss, Megan H. Powdrill, John Paul Pezacki
Meeting Abstract
Biotechnology & Applied Microbiology
Ross Wilson, Lorena de Onate, Dana Foss, Rima Mendonsa
Meeting Abstract
Chemistry, Multidisciplinary
Dana C. Danielson, Jenny Cheng, Roger Koukiekolo, Zygmunt Jakubek, John P. Pezacki
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2011)
Meeting Abstract
Biochemistry & Molecular Biology
Noreen Ahmed, Nadine Ahmed, Dana Foss, John Pezacki