Longitudinal measures of proteostasis in live neurons: Features that determine fate in models of neurodegenerative disease

Autophagy activation ameliorates neuronal pathogenesis of FTLD-U mice

(2012) I-Fang Wang et al.   Autophagy

Induced Pluripotent Stem Cells from Patients with Huntington's Disease Show CAG-Repeat-Expansion-Associated Phenotypes

(2012) The HD iPSC Consortium   Cell Stem Cell

Disease-specific phenotypes in dopamine neurons from human iPS-based models of genetic and sporadic Parkinson's disease

(2012) Adriana Sánchez-Danés et al.   EMBO Molecular Medicine

Microglia and neurodegeneration: The role of systemic inflammation

(2012) Colm Cunningham   GLIA

Loss of leucine-rich repeat kinase 2 causes age-dependent bi-phasic alterations of the autophagy pathway

(2012) Youren Tong et al.   Molecular Neurodegeneration

Sustained translational repression by eIF2α-P mediates prion neurodegeneration

(2012) Julie A. Moreno et al.   NATURE

Mutant induced pluripotent stem cell lines recapitulate aspects of TDP-43 proteinopathies and reveal cell-specific vulnerability

(2012) B. Bilican et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Profile of Inflammatory Mediators in Gestational Diabetes Mellitus: Phenotype and Genotype

(2011) Bárbara Yasmin Gueuvoghlanian-Silva et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

LRRK2 Mutant iPSC-Derived DA Neurons Demonstrate Increased Susceptibility to Oxidative Stress

(2011) Ha Nam Nguyen et al.   Cell Stem Cell

From Systems Biology to Systems Biomedicine

(2011) Paul MA Antony et al.   CURRENT OPINION IN BIOTECHNOLOGY

Direct Membrane Association Drives Mitochondrial Fission by the Parkinson Disease-associated Protein α-Synuclein

(2011) Ken Nakamura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identifying polyglutamine protein species in situ that best predict neurodegeneration

(2011) Jason Miller et al.   Nature Chemical Biology

Firefly luciferase mutants as sensors of proteome stress

(2011) Rajat Gupta et al.   NATURE METHODS

A handle on neurodegenerative disease complexity

(2011) Erika Pastrana   NATURE METHODS

LRRK2 expression in idiopathic and G2019S positive Parkinson's disease subjects: a morphological and quantitative study

(2011) S. Sharma et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Neuronal circuitry regulates the response of Caenorhabditis elegans to misfolded proteins

(2011) V. Prahlad et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Physical limits of cells and proteomes

(2011) K. A. Dill et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cell-autonomous and non-cell-autonomous toxicity in polyglutamine diseases

(2011) Fabio Sambataro et al.   PROGRESS IN NEUROBIOLOGY

Ageing, neurodegeneration and Parkinson's disease

(2010) J. V. Hindle   AGE AND AGEING

Mechanisms of Synapse and Dendrite Maintenance and Their Disruption in Psychiatric and Neurodegenerative Disorders

(2010) Yu-Chih Lin et al.   Annual Review of Neuroscience

Cellular Proteomes Have Broad Distributions of Protein Stability

(2010) Kingshuk Ghosh et al.   BIOPHYSICAL JOURNAL

Regression modeling of competing risk using R: an in depth guide for clinicians

(2010) L Scrucca et al.   BONE MARROW TRANSPLANTATION

Conformation Sensors that Distinguish Monomeric Proteins from Oligomers in Live Cells

(2010) Yasmin M. Ramdzan et al.   CHEMISTRY & BIOLOGY

Diseases as network perturbations

(2010) Antonio del Sol et al.   CURRENT OPINION IN BIOTECHNOLOGY

Protein homeostasis and synaptic plasticity

(2010) Iván J Cajigas et al.   EMBO JOURNAL

Protein homeostasis and aging in neurodegeneration

(2010) Peter M. Douglas et al.   JOURNAL OF CELL BIOLOGY

Quantitative Relationships between Huntingtin Levels, Polyglutamine Length, Inclusion Body Formation, and Neuronal Death Provide Novel Insight into Huntington's Disease Molecular Pathogenesis

(2010) J. Miller et al.   JOURNAL OF NEUROSCIENCE

Cytoplasmic Mislocalization of TDP-43 Is Toxic to Neurons and Enhanced by a Mutation Associated with Familial Amyotrophic Lateral Sclerosis

(2010) S. J. Barmada et al.   JOURNAL OF NEUROSCIENCE

Monitoring protein aggregation and toxicity in Alzheimer’s disease mouse models using in vivo imaging

(2010) Tara L. Spires-Jones et al.   METHODS

Studying protein degradation pathways in vivo using a cranial window-based approach

(2010) Vivek K. Unni et al.   METHODS

Autophagy gone awry in neurodegenerative diseases

(2010) Esther Wong et al.   NATURE NEUROSCIENCE

Prion-like transmission of protein aggregates in neurodegenerative diseases

(2010) Patrik Brundin et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Review: Autophagy and neurodegeneration: survival at a cost?

(2010) S. J. Cherra III et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

In Vivo Imaging of α-Synuclein in Mouse Cortex Demonstrates Stable Expression and Differential Subcellular Compartment Mobility

(2010) Vivek K. Unni et al.   PLoS One

A small-molecule scaffold induces autophagy in primary neurons and protects against toxicity in a Huntington disease model

(2010) A. S. Tsvetkov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Efficient Generation of Functional Dopaminergic Neurons from Human Induced Pluripotent Stem Cells Under Defined Conditions

(2010) Andrzej Swistowski et al.   STEM CELLS

The Unfolded Protein Response Is Activated in Pretangle Neurons in Alzheimer's Disease Hippocampus

(2009) Jeroen J.M. Hoozemans et al.   AMERICAN JOURNAL OF PATHOLOGY

The virtual cell--a candidate co-ordinator for 'middle-out' modelling of biological systems

(2009) D. C. Walker et al.   BRIEFINGS IN BIOINFORMATICS

Transient Non-native Hydrogen Bonds Promote Activation of a Signaling Protein

(2009) Alexandra K. Gardino et al.   CELL

Parkinson's Disease Patient-Derived Induced Pluripotent Stem Cells Free of Viral Reprogramming Factors

(2009) Frank Soldner et al.   CELL

High-content screening of primary neurons: ready for prime time

(2009) Aaron Daub et al.   CURRENT OPINION IN NEUROBIOLOGY

Stochastic variation: From single cells to superorganisms

(2009) Maria L. Kilfoil et al.   HFSP Journal

A systems approach to prion disease

(2009) Daehee Hwang et al.   Molecular Systems Biology

An expanding arsenal of experimental methods yields an explosion of insights into protein folding mechanisms

(2009) Alice I Bartlett et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Role of Intrinsically Unstructured Proteins in Neurodegenerative Diseases

(2009) Swasti Raychaudhuri et al.   PLoS One

Collapse of proteostasis represents an early molecular event in Caenorhabditis elegans aging

(2009) A. Ben-Zvi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Network strategies to understand the aging process and help age-related drug design

(2009) Gábor I Simkó et al.   Genome Medicine

Destabilizing Protein Polymorphisms in the Genetic Background Direct Phenotypic Expression of Mutant SOD1 Toxicity

(2009) Tali Gidalevitz et al.   PLoS Genetics

Use of Penalized Splines in Extended Cox-Type Additive Hazard Regression to Flexibly Estimate the Effect of Time-varying Serum Uric Acid on Risk of Cancer Incidence: A Prospective, Population-Based Study in 78,850 Men

(2008) Alexander M. Strasak et al.   ANNALS OF EPIDEMIOLOGY

Mistranslation-Induced Protein Misfolding as a Dominant Constraint on Coding-Sequence Evolution

(2008) D. Allan Drummond et al.   CELL

Macromolecular Crowding Compacts Unfolded Apoflavodoxin and Causes Severe Aggregation of the Off-pathway Intermediate during Apoflavodoxin Folding

(2008) Ruchira Engel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Residue-Level Interrogation of Macromolecular Crowding Effects on Protein Stability

(2008) Lisa M. Charlton et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Survival analysis: time-dependent effects and time-varying risk factors

(2008) Friedo W. Dekker et al.   KIDNEY INTERNATIONAL

The analysis of survival data: the Kaplan–Meier method

(2008) Kitty J. Jager et al.   KIDNEY INTERNATIONAL

The analysis of survival data in nephrology: basic concepts and methods of Cox regression

(2008) Paul C. van Dijk et al.   KIDNEY INTERNATIONAL

Comparative Proteomic Phenotyping of Cell Lines and Primary Cells to Assess Preservation of Cell Type-specific Functions

(2008) Cuiping Pan et al.   MOLECULAR & CELLULAR PROTEOMICS

Crowded, cell-like environment induces shape changes in aspherical protein

(2008) D. Homouz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chaperone-dependent amyloid assembly protects cells from prion toxicity

(2008) P. M. Douglas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neurons derived from reprogrammed fibroblasts functionally integrate into the fetal brain and improve symptoms of rats with Parkinson's disease

(2008) M. Wernig et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of the Cellular Heat Shock Response in Caenorhabditis elegans by Thermosensory Neurons

(2008) V. Prahlad et al.   SCIENCE

Adapting Proteostasis for Disease Intervention

(2008) William E. Balch et al.   SCIENCE