Anticalins: Exploiting a non-Ig scaffold with hypervariable loops for the engineering of binding proteins

Anticalins: An emerging class of novel biologics to treat cancer and other severe diseases

(2014) A. Skerra   DRUGS OF THE FUTURE

Tumor-Targeting Antibody–Anticalin Fusion Proteins for in Vivo Pretargeting Applications

(2013) Martina Steiner et al.   BIOCONJUGATE CHEMISTRY

VEGF in Tumor Progression and Targeted Therapy

(2013) Vladimir P. Chekhonin et al.   CURRENT CANCER DRUG TARGETS

A Highly Potent and Specific MET Therapeutic Protein Antagonist with Both Ligand-Dependent and Ligand-Independent Activity

(2013) Shane A. Olwill et al.   MOLECULAR CANCER THERAPEUTICS

PASylation: a biological alternative to PEGylation for extending the plasma half-life of pharmaceutically active proteins

(2013) M. Schlapschy et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Construction of ribosome display library based on lipocalin scaffold and screening anticalins with specificity for estradiol

(2012) Jianqing Liu et al.   ANALYST

The future of antibodies as cancer drugs

(2012) Janice M. Reichert et al.   DRUG DISCOVERY TODAY

Combinatorial Design of an Anticalin Directed against the Extra-Domain B for the Specific Targeting of Oncofetal Fibronectin

(2012) Michaela Gebauer et al.   JOURNAL OF MOLECULAR BIOLOGY

Abstract A212: First in human phase I study of PRS-050 (Angiocal), a VEGF-A targeting anticalin, in patients with advanced solid tumors: Results of a dose escalation study.

(2012) K. Mross et al.   MOLECULAR CANCER THERAPEUTICS

Intravenous application of an anticalin dramatically lowers plasma digoxin levels and reduces its toxic effects in rats

(2012) Florian Eyer et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Therapeutic antibodies: Market considerations, disease targets and bioprocessing

(2011) John G. Elvin et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

High-throughput Sorting of an Anticalin Library via EspP-mediated Functional Display on the Escherichia coli Cell Surface

(2010) Uli Binder et al.   JOURNAL OF MOLECULAR BIOLOGY

A new crystal form of human tear lipocalin reveals high flexibility in the loop region and induced fit in the ligand cavity

(2009) Daniel A. Breustedt et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

High-Affinity Recognition of Lanthanide(III) Chelate Complexes by a Reprogrammed Human Lipocalin 2

(2009) Hyun Jin Kim et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Single domain antibodies: promising experimental and therapeutic tools in infection and immunity

(2009) Janusz Wesolowski et al.   MEDICAL MICROBIOLOGY AND IMMUNOLOGY

An engineered lipocalin specific for CTLA-4 reveals a combining site with structural and conformational features similar to antibodies

(2009) D. Schonfeld et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Camelid immunoglobulins and nanobody technology

(2008) S. Muyldermans et al.   VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY