Article
Cardiac & Cardiovascular Systems
Liqun Li, Qiang Liu, Tongyao Shang, Wei Song, Dongmei Xu, Thaddeus D. Allen, Xia Wang, James Jeong, Corrinne G. Lobe, Ju Liu
Summary: The study established a transgenic mouse model with aberrant activation of the Notch1 signaling pathway, revealing that activated Notch1 signaling resulted in decreased VE-cadherin expression, dysfunction of the glomerular filtration barrier, and induction of albuminuria.
CIRCULATION RESEARCH
(2021)
Article
Medicine, Research & Experimental
Mohamed A. Saleh, Ahmed A. Shaaban, Iman M. Talaat, Atef Elmougy, Saryia F. Adra, Firdos Ahmad, Rizwan Qaisar, Adel B. Elmoselhi, Eman Abu-Gharbieh, Waseem El-Huneidi, Mohamed A. Eladl, George Shehatou, Hoda E. Kafl
Summary: This study investigated the potential role of ET-1 receptors in kidney diseases and found that ET-1 increases glomerular permeability and albuminuria by modulating the activity of the ETA-RhoA/ROCK-1/2 pathway. Selective ETA receptor blockade may represent a potential therapeutic strategy to limit glomerular injury and albuminuria.
Article
Biochemistry & Molecular Biology
Ki Ryang Na, Jin Young Jeong, Jin Ah Shin, Yoon-Kyung Chang, Kwang-Sun Suh, Kang Wook Lee, Dae Eun Choi
Summary: Recent studies have shown that mitochondrial disruption in podocytes can lead to glomerular diseases, particularly diabetic nephropathy. Deficiency of CRIF1 gene results in podocyte dysfunction and progressive glomerular sclerosis and tubulointerstitial diseases in mice. The study demonstrates a link between podocyte mitochondrial dysfunction and the development of glomerular diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Urology & Nephrology
Linus Butt, David Unnersjoe-Jess, Martin Hoehne, Robert Hahnfeldt, Dervla Reilly, Markus M. Rinschen, Ingo Plagmann, Paul Diefenhardt, Sebastian Braehler, Paul T. Brinkkoetter, Hjalmar Brismar, Hans Blom, Bernhard Schermer, Thomas Benzing
Summary: This study demonstrated the pathogenic effect of podocin R231Q on its own, supporting the notion of podocin R229Q contributing to genetic predisposition in adult patients.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Article
Medicine, General & Internal
Ping Liu, Rob R. Quinn, Ngan N. Lam, Huda Al-Wahsh, Manish M. Sood, Navdeep Tangri, Marcello Tonelli, Pietro Ravani
Summary: This study found that with advancing age, CKD regression and death were more likely than CKD progression or kidney failure. These findings have important implications for patient care and for assessing the potential effect of population aging on the burden of CKD.
Article
Medicine, General & Internal
Maggie Wang, Samson S. Peter, Chi D. Chu, Delphine S. Tuot, Jonathan H. Chen
Summary: The findings of this study suggest that nearly half of patients with CKD at high risk of progressing to kidney failure do not have a nephrologist visit within 1 year of established risk.
Article
Cardiac & Cardiovascular Systems
Yelena Drexler, Julien Tremblay, Robert A. Mesa, Bailey Parsons, Efren Chavez, Gabriel Contreras, Alessia Fornoni, Leopoldo Raij, Samuel Swift, Tali Elfassy
Summary: This study found a strong association between albuminuria and mortality risk, even at mildly increased levels. The association persisted across different demographic and comorbidity factors, with some subtle differences.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Microbiology
Alexandra I. Wells, Kalena A. Grimes, Kenneth Kim, Emilie Branche, Christopher J. Bakkenist, William H. DePas, Sujan Shresta, Carolyn B. Coyne
Summary: The expression of human neonatal Fc receptor (hFcRn) and the ablation of type I interferon signaling were identified as key host determinants involved in echovirus pathogenesis. While hFcRn expression alone is insufficient to confer susceptibility to echovirus infections in mice, expression of hFcRn in mice deficient in type I interferon signaling results in echovirus pathogenesis similar to that observed in humans, including a robust systemic immune response and liver damage. This study establishes in vivo models that recapitulate echovirus disease in humans, providing valuable insights into the pathogenesis of echovirus infections.
Article
Cell Biology
Eun Young Kim, Stuart E. Dryer
Summary: Canonical transient receptor potential-6 (TRPC6) channels play a role in various glomerular diseases, but their involvement in the proteinuric state is still unclear. In this study, TRPC6 knockout was found to attenuate albumin overload-induced proteinuria in rats, although its protective effect on tubulointerstitial compartments depends on the disease model.
Article
Multidisciplinary Sciences
Dirk den Braanker, Rutger Maas, Naomi Parr, Jeroen Deegens, Bart Smeets, Jack Wetzels, Johan van der Vlag, Tom Nijenhuis
Summary: In this study, a Thy-1.1 transgenic mouse model prone to FSGS was developed to accelerate proteinuria after injection of samples from FSGS patients. It was found that different genetic backgrounds in mice resulted in varying onset and severity of proteinuria. The experiment demonstrated that presumably CPF-containing plasmapheresis effluent induced proteinuria, but not serum. This model can be used to study CPFs, but lacks sensitivity for predicting FSGS recurrence in a clinical setting.
Review
Biochemistry & Molecular Biology
Wataru Fujii, Shigeru Shibata
Summary: This article reviews the extensive research conducted over the past 80 years on the regulation and action of the mineralocorticoid receptor (MR). It highlights the role of MR and the steroid hormone aldosterone in integrating responses of tubular cells and maintaining fluid homeostasis, as well as their dysregulation in kidney diseases. Experimental studies have shown the pathological consequences of MR overactivity and the mechanisms of enhanced MR signaling, while clinical studies have demonstrated the renoprotective effects of MR blockade. The article also discusses future areas of investigation, including the use of non-steroidal MR antagonists in non-diabetic kidney disease patients and the search for downstream mediators of renoprotection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
John M. Basgen, Jenny S. Wong, Justina Ray, Susanne B. Nicholas, Kirk N. Campbell
Summary: The study showed that 2-week old WT and Cd2ap KO mice have similar levels of albuminuria, glomerular and mesangial volume, but Cd2ap KO mice have more extensive podocyte foot process effacement. This suggests that podocyte injury may be the initiating event leading to mesangial expansion and albuminuria in this model.
FRONTIERS IN MEDICINE
(2021)
Article
Engineering, Biomedical
Dan Wang, Snehal Sant, Nicholas Ferrell
Summary: This study explores the roles of GBM and podocytes in the glomerular filtration barrier, and develops a 3D cell culture model to evaluate their effects on molecular diffusion. The results indicate that GBM alone provides a stringent barrier, while podocytes further restrict molecular diffusion.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Chemistry, Analytical
Chathura S. Abeywickrama, Yonghao Li, Ashweni Ramanah, Dilani N. Owitipana, Kaveesha J. Wijesinghe, Yi Pang
Summary: A series of fluorescent probes based on [4-(diphenylamino)]styrylbenzothiazolium were synthesized to investigate their binding properties with albumin. One of the probes exhibited significant fluorescence turn ON upon addition of serum albumin, showing high sensitivity for detecting albumin in aqueous solution with a low limit of detection. Spectrometric fluorescence titrations were conducted to study the selectivity, sensitivity, and stability of the probe-albumin complex, and the probe's binding specificity was further explored through competitive displacement method.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Endocrinology & Metabolism
Ofri Mosenzon, Stephen D. Wiviott, Hiddo J. L. Heerspink, Jamie P. Dwyer, Avivit Cahn, Erica L. Goodrich, Aliza Rozenberg, Meir Schechter, Ilan Yanuv, Sabina A. Murphy, Thomas A. Zelniker, Ingrid A. M. Gause-Nilsson, Anna Maria Langkilde, Martin Fredriksson, Peter A. Johansson, Deepak L. Bhatt, Lawrence A. Leiter, Darren K. McGuire, John P. H. Wilding, Marc S. Sabatine, Itamar Raz
Summary: In the DECLARE-TIMI 58 trial, dapagliflozin showed a positive impact on urinary albumin-to-creatinine ratio and renal-specific outcomes, improving across baseline UACR categories; indicating a potential role for SGLT2i in the primary prevention of diabetic kidney disease.
Correction
Urology & Nephrology
A. H. J. Kim, H. Suleiman, A. S. Shaw
CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION
(2016)
Review
Urology & Nephrology
Alfred H. J. Kim, Hani Suleiman, Andrey S. Shaw
CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION
(2016)
Article
Urology & Nephrology
Sebastian Brahler, Haiyang Yu, Hani Suleiman, Gokul M. Krishnan, Brian T. Saunders, Jeffrey B. Kopp, Jeffrey H. Miner, Bernd H. Zinselmeyer, Andrey S. Shaw
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2016)
Article
Cell Biology
S. Kuusela, H. Wang, A. A. Wasik, H. Suleiman, S. Lehtonen
CELL DEATH & DISEASE
(2016)
Article
Multidisciplinary Sciences
Christoph Schell, Manuel Rogg, Martina Suhm, Martin Helmstaedter, Dominik Sellung, Mako Yasuda-Yamahara, Oliver Kretz, Victoria Kuettner, Hani Suleiman, Laxmikanth Kollipara, Rene P. Zahedi, Albert Sickmann, Stefan Eimer, Andrey S. Shaw, Albrecht Kramer-Zucker, Mariko Hirano-Kobayashi, Takaya Abe, Shinichi Aizawa, Florian Grahammer, Bjoern Hartleben, Joern Dengjel, Tobias B. Huber
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2017)
Article
Multidisciplinary Sciences
Kenji Tsuji, Teodor G. Paunescu, Hani Suleiman, Dongping Xie, Fahmy A. Mamuya, Jeffrey H. Miner, Hua A. Jenny Lu
SCIENTIFIC REPORTS
(2017)
Article
Urology & Nephrology
Meei-Hua Lin, Joseph B. Miller, Yamato Kikkawa, Hani Y. Suleiman, Karl Tryggvason, Bradley L. Hodges, Jeffrey H. Miner
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2018)
Article
Multidisciplinary Sciences
Kenji Tsuji, Hani Suleiman, Jeffrey H. Miner, James M. Daley, Diane E. Capen, Teodor G. Paunescu, Hua A. Jenny Lu
SCIENTIFIC REPORTS
(2017)
Article
Urology & Nephrology
Liang Ning, Hani Y. Suleiman, Jeffrey H. Miner
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2020)
Article
Urology & Nephrology
Michael J. Randles, Franziska Lausecker, Qingyang Kong, Hani Suleiman, Graeme Reid, Maria Kolatsi-Joannou, Bernard Davenport, Pinyuan Tian, Sara Falcone, Paul Potter, Tom Van Agtmael, Jill T. Norman, David A. Long, Martin J. Humphries, Jeffrey H. Miner, Rachel Lennon
Summary: Ultrastructural changes in basement membranes are associated with altered cell adhesion and metabolic processes, and distinct matrix proteomes were identified in aging and kidney disease progression in mice. Basement membrane components were reduced while interstitial matrix proteins were increased, a pattern also observed in human kidney aging and disease datasets. This study provides insight into mechanisms of response to kidney injury and repair.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Article
Urology & Nephrology
Chengqing Qu, Robyn Roth, Pongpratch Puapatanakul, Charles Loitman, Dina Hammad, Guy M. Genin, Jeffrey H. Miner, Hani Y. Suleiman
Summary: A new visualization technique has been developed to reveal the detailed three-dimensional organization of actin networks in healthy podocytes, providing insights into how podocytes respond to mechanical cues from their surrounding environment.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Article
Physiology
Liang Ning, Hani Y. Suleiman, Jeffrey H. Miner
Summary: In a study investigating the impact of Synaptopodin (Synpo) deficiency on Alport syndrome (AS) in mice, it was found that lack of Synpo accelerated disease progression, leading to more severe proteinuria and glomerulosclerosis. The absence of Synpo also affected the distribution of myosin IIA in podocytes, suggesting that the actin cytoskeleton of podocytes could be a potential therapeutic target in AS.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2021)
Meeting Abstract
Surgery
D. Hammad, J. H. Miner, T. Alhamad, H. Suleiman
AMERICAN JOURNAL OF TRANSPLANTATION
(2019)
Article
Urology & Nephrology
Sebastian Brahler, Bernd H. Zinselmeyer, Saravanan Raju, Maximilian Nitschke, Hani Suleiman, Brian T. Saunders, Michael W. Johnson, Alexander M. C. Boehner, Susanne F. Viehmann, Derek J. Theisen, Nicole M. Kretzer, Carlos G. Briseno, Konstantin Zaitsev, Olga Ornatsky, Qing Chang, Javier A. Carrero, Jeffrey B. Kopp, Maxim N. Artyomov, Christian Kurts, Kenneth M. Murphy, Jeffrey H. Miner, Andrey S. Shaw
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2018)
Article
Medicine, Research & Experimental
Hani Y. Suleiman, Robyn Roth, Sanjay Jain, John E. Heuser, Andrey S. Shaw, Jeffrey H. Miner