Journal
FEBS LETTERS
Volume 588, Issue 3, Pages 401-407Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2013.12.010
Keywords
DR6; Agonist antibody; Death domain; TRADD
Funding
- National Natural Science Foundation of China [31370911]
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Death receptor 6 (DR6) is a member of the death domain-containing receptors that belong to the TNFR superfamily. To date, the ligand for DR6 is still not clearly defined. Here, we developed a functional agonist monoclonal antibody (DQM3) against DR6, which bound to the first cysteine-rich domain. Importantly, DR6 signaling could be clearly activated by DQM3, which was dependent on its intracellular death domain. In addition, we demonstrated that the association between DR6 and TRADD was enhanced upon DQM3 stimulation and TRADD was involved in DR6-induced signaling activation. Taken together, our findings provide new insight into a novel mechanism by which DR6 induces downstream signaling in response to an agonist antibody. Structured summary of protein interactions: DR6 physically interacts with TRADD by anti bait coimmunoprecipitation (View interaction) (C) 2013 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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