Journal
FEBS LETTERS
Volume 587, Issue 12, Pages 1779-1786Publisher
WILEY
DOI: 10.1016/j.febslet.2013.04.029
Keywords
Retinoblastoma; PAX6; MicroRNA-365b-3p; Cell cycle; Cell apoptosis
Funding
- Heilongjiang Natural Science Foundation for Young Scientists [QC07C94]
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miR-365b-3p inhibits cell growth, induces cell cycle arrest and apoptosis by directly targeting PAX6, suggesting a potential therapeutic target for retinoblastoma.
PAX6 contributes to the development and progression of retinoblastoma (RB), but the molecular mechanism underlying the regulation of PAX6 expression is unclear. Here we found that microRNA-365b-3p (miR-365b-3p) is downregulated in human RB tissues. Ectopic expression of miR-365b-3p significantly attenuates cell growth, induces cell cycle arrest in G1 phase and cell apoptosis through inhibiting the expression of PAX6 by directly binding its 3' untranslated regions. Furthermore, overexpression of miR-365b-3p upregulates p21 and p27 but downregulates cdc2 and Cyclin D1 protein levels. Elucidating the regulatory mechanism of PAX6 by microRNAs may give new clues to the therapy against RB. (C) 2013 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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