Journal
FEBS LETTERS
Volume 586, Issue 17, Pages 2780-2786Publisher
WILEY
DOI: 10.1016/j.febslet.2012.04.028
Keywords
SPOT synthesis; Protein interaction domains; SH3 domains; WW domains; PDZ domains; Peptide arrays
Funding
- Deutsche Forschungsgemeinschaft
- FEBS federation
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Synthetic peptide array technology was first developed in the early 1990s by Ronald Frank. Since then the technique has become a powerful tool for high throughput approaches in biology and biochemistry. Here, we focus on peptide arrays applied to investigate the binding specificity of protein interaction domains such as WW, SH3, and PDZ domains. We describe array-based methods used to reveal domain networks in yeast, and briefly review rules as well as ideas about the synthesis and application of peptide arrays. We also provide initial results of a study designed to investigate the nature and evolution of SH3 domain interaction networks in eukaryotes. (C) 2012 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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