Journal
FEBS LETTERS
Volume 586, Issue 20, Pages 3753-3760Publisher
WILEY
DOI: 10.1016/j.febslet.2012.09.010
Keywords
hRIP alpha; RPA; Nuclear transport; Cervical cancer; Cell proliferation
Funding
- National Research Foundation of Korea
- Korean Government [2010-0009567]
- National R&D Program for Cancer Control, Ministry for Health and Welfare, Republic of Korea [1120280]
- Korea Health Promotion Institute [1120280] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- National Research Foundation of Korea [2010-0009567] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Replication protein A (RPA) is a eukaryotic single-stranded DNA binding protein that is essential for DNA replication, repair, and recombination, and human RPA interacting protein alpha (hRIP alpha) is the nuclear transporter of RPA. Here, we report the regulatory role of hRIP alpha protein in cell proliferation. Western blot analysis revealed that the level of hRIP alpha was frequently elevated in cervical tumors tissues and hRIP alpha knockdown by siRNA inhibited cellular proliferation through deregulation of the cell cycle. In addition, overexpression of hRIP alpha resulted in increased clonogenicity. These results indicate that hRIP alpha is involved in cell proliferation through regulation of RPA transport. (C) 2012 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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