Journal
FEBS LETTERS
Volume 586, Issue 19, Pages 3508-3521Publisher
WILEY
DOI: 10.1016/j.febslet.2012.08.007
Keywords
miR-518b; Esophageal squamous cell carcinoma; Proliferation; Invasion; Rap1b
Funding
- Chinese National Natural Science Foundation Projects [NSFC 81072053]
Ask authors/readers for more resources
MicroRNAs (miRNAs) represent a class of small non-coding RNAs that regulate gene expression at the post-transcriptional levels. Recent studies show that miRNAs may function as oncogenes or tumor suppressor genes. In this study, we demonstrated that miR-518b was down-regulated in esophageal squamous cell carcinoma (ESCC) tissues and correlated with metastasis and survival. miR-518b suppressed the proliferation by inducing apoptosis and repressed the invasion in ESCC cells, but had no effect on the cell cycle. Furthermore, Rap1b was revealed to be directly regulated by miR-518b. These findings indicate that miR-518b may function as a tumor suppressor by targeting Rap1b in the development of ESCC and has important clinical and prognostic value. (C) 2012 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available