Journal
FEBS LETTERS
Volume 586, Issue 19, Pages 3142-3149Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2012.08.015
Keywords
Bcl-rambo; Bcl-2; Permeability transition; ANT; Apoptosis
Funding
- Kyung Hee University [KHU-20100136]
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The Bcl-2 family proteins plays a central role in apoptosis. The pro- or anti-apoptotic activities of Bcl-2 family are dependent on the Bcl-2 homology (BH) regions. Bcl-rambo, a new pro-apoptotic member, is unusual in that its pro-apoptotic activity is independent of its BH domains. However, the mechanism underlying Bcl-rambo-induced apoptosis is largely unknown. Mitochondrial localization is indispensable for the pro-apoptotic function of Bcl-rambo. Bcl-rambo interacts physically with the adenine nucleotide translocator (ANT), suppresses the ADT/ATP-dependent translocation activity of ANT. Collectively, our data indicate Bcl-rambo is a pro-apoptotic member of the Bcl-2 family, induces the permeability transition via interaction with ANT. Structured summary of protein interactions: Bcl-Rambo and HSP60 colocalize by fluorescence microscopy (View interaction) Bcl-rambo binds to ANTI by pull down (View interaction) (C) 2012 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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