Article
Immunology
Atila Duque Rossi, Luiza Mendonca Higa, Alice Laschuk Herlinger, Marcelo Ribeiro-Alves, Mariane Talon de Menezes, Ana Lucia Moraes Giannini, Cynthia Chester Cardoso, Andrea T. T. Da Poian, Amilcar Tanuri, Renato Santana Aguiar
Summary: An analysis of the expression levels of 754 human microRNAs in DENV-infected THP-1 cells revealed differential expression of 11 human microRNAs, with gene ontology and enrichment analysis highlighting potential biological processes affected by these molecules.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Medicine, Research & Experimental
Jeffrey O. Adoga, Mahendra L. Channa, Anand Nadar
Summary: This study investigated the effect of kolaviron on gene expression related to insulin signaling pathway and metabolism regulation in the heart of type-2 diabetic rats. The results showed that kolaviron modulated the expression profile of these genes, potentially offering a therapeutic approach for vascular dysfunction and complications in type-2 diabetes through the activation of the NRF-2/AKT-1/eNOS signaling pathway and suppression of the NF-kB/PKC signaling pathway.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Irina Gilyazova, Elizaveta Ivanova, Himanshu Gupta, Artur Mustafin, Ruslan Ishemgulov, Adel Izmailov, Gulshat Gilyazova, Elena Pudova, Valentin Pavlov, Elza Khusnutdinova, Bo-Ying Bao, Yung-Hsiang Chen
Summary: This study aimed to investigate the miRNA profile in tissue samples obtained from patients with prostate cancer (PCa) and find potential markers for diagnosis and prognosis. The study found that certain miRNAs were downregulated in early-stage cancer patients, which may be useful for diagnosing and predicting PCa.
Article
Biochemistry & Molecular Biology
Carlos Roma-Mateo, Sheila Lorente-Pozo, Lucia Marquez-Thibaut, Mireia Moreno-Estelles, Concepcion Garces, Dayme Gonzalez, Marcos Lahuerta, Carmen Aguado, Jose Luis Garcia-Gimenez, Pascual Sanz, Federico V. V. Pallardo
Summary: Lafora disease is a rare, fatal form of progressive myoclonus epilepsy characterized by intracellular accumulation of abnormal polyglucosan granules. Experimental mouse models deficient in laforin or malin proteins provide evidence of molecular and cellular alterations in neural tissue. Overexpression of miR-155 and miR-146a in an age-dependent manner and altered gene expression in brain extracts indicate their potential role as biomarkers for disease progression in LD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Julie Weidner, Carina Malmhall, Vahid Arabkari, Aidan Barrett, Emma Boberg, Linda Ekerljung, Madeleine Radinger
Summary: The polarization of CD4+ T cells into different T helper subsets is a crucial process in many diseases, including asthma. miR-19a has been identified as a regulator in T cell polarization by negatively controlling the expression of the SGK1 gene, therefore affecting T cell development. Thus, miR-19a plays an important role in the binding and regulation of SGK1 transcript levels during T cell development.
Article
Multidisciplinary Sciences
Mohamed K. Hassan, Amr A. Waly, Waheba Elsayed, Sarah Keshk, Walaa Ramadan Allam, Sherif F. El-khamisy
Summary: This study identified 157 downregulated miRNAs in PTX-resistant ovarian cancer cells compared to parental controls. Five miRNAs were restored after epigenetic modulation, targeting the PI3K-AKT pathway associated with cell cycle progression and survival. Upregulated genes in PTX-resistant cells mainly involved in cell cycle and survival were also confirmed.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Stella B. Somiari, Susan Shuss, Jianfang Liu, Kimberly Mamula, Amy O'Donnell, Brenda Deyarmin, Jennifer Kane, Amber Greenawalt, Caroline Larson, Sean Rigby, Hai Hu, Craig D. Shriver
Summary: This study evaluated the impact of prolonged exposure to room temperature on RNA quality in non-diseased breast tissue. The results showed that up to 190 minutes after excision, higher RNA Integrity Numbers (RINs) were obtained. Further exposure of up to 180 minutes had no significant effect on RIN values. This study strengthens the rationale for assessing RIN and specific gene transcript levels as an objective method for determining RNA suitability for research purposes.
Article
Biochemistry & Molecular Biology
Xiuli Shao, Xiaolin Zhang, Lei Yang, Ruijia Zhang, Rongli Zhu, Rui Feng
Summary: Cardiac remodelling is a common characteristic of heart diseases, especially heart failure. MicroRNA and mRNA are potential diagnostic markers and therapeutic targets for heart failure. MicroRNA-mRNA interaction network analysis identified miR-542-3p-CILP as a potential new mechanism in ischaemic cardiomyopathy-induced heart failure.
Letter
Medicine, General & Internal
Pratishtha Mehra, Vimal Mehta, Jamal Yusuf, Rishi Sukhija, Wilbert S. Aronow
Summary: This study found that ET-1 and ETA gene polymorphisms are more prevalent in patients with pulmonary hypertension associated with rheumatic mitral valve disease (PH-MVD), suggesting that these genes may predispose individuals to the development of PH.
ARCHIVES OF MEDICAL SCIENCE
(2022)
Article
Multidisciplinary Sciences
Michiyo Maruyama, Yuko Furukawa, Masato Kinoshita, Atsushi Mukaiyama, Shuji Akiyama, Takashi Yoshimura
Summary: This study established a model using medaka fish to investigate the role of adenylate kinase (Ak) in environmental adaptation. The findings suggest that Ak can modulate locomotor activity by regulating cellular energy balance.
Article
Multidisciplinary Sciences
Paula Gutierrez-Perez, Emilio M. Santillan, Thomas Lendl, Jingkui Wang, Anna Schrempf, Thomas L. Steinacker, Mila Asparuhova, Marlene Brandstetter, David Haselbach, Luisa Cochella
Summary: The study reveals the vulnerability of muscle cells by miR-1, which represses multiple subunits of the V-ATPase complex, impacting muscle function. This sheds light on a previously unknown role for microRNAs in regulating protein complexes and V-ATPase assembly as a conserved muscle cell vulnerability.
Article
Oncology
Yuchen Liu, Pengxiang Chen, Tianyu Liu, Bo Cheng, Changhua Sun, Huixian Xin, Zhihua Wen, Yufeng Cheng
Summary: This study aimed to explore the roles of endothelin-1 (ET-1) in radiation-induced myocardial fibrosis (RIMF) and the potential of docosahexaenoic acid (DHA) in preventing RIMF. The results showed that radiation increased ET-1 expression and secretion, promoting the activation of cardiac fibroblasts. DHA effectively inhibited fibroblast activation by targeting the p38/ET-1 pathway and attenuated cardiac fibrosis caused by radiation.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2023)
Article
Multidisciplinary Sciences
Yuting Jiang, Xiao Yang, Linlin Li, Xin Lv, Ruixue Wang, Hongguo Zhang, Ruizhi Liu
Summary: By studying the differentially expressed genes (DEGs) in patients with Sertoli cell-only syndrome (SCOS), potential biomarkers related to SCOS were identified, which may have clinical relevance in the diagnosis and treatment of SCOS.
SCIENTIFIC REPORTS
(2023)
Article
Cardiac & Cardiovascular Systems
Su Ern Yeoh, Kieran F. Docherty, Ross T. Campbell, Pardeep S. Jhund, Ann Hammarstedt, Hiddo J. L. Heerspink, Petr Jarolim, Lars Kober, Mikhail N. Kosiborod, Felipe A. Martinez, Piotr Ponikowski, Scott D. Solomon, Mikaela Sjoestrand, Olof Bengtsson, Peter J. Greasley, Naveed Sattar, Paul Welsh, Marc S. Sabatine, David A. Morrow, John J. V. McMurray
Summary: ET-1 is implicated in heart failure and renal disease. This study investigated the relationship between ET-1 and clinical outcomes, as well as the efficacy of dapagliflozin in heart failure patients. Higher baseline ET-1 was associated with worse outcomes and decline in kidney function, while dapagliflozin showed consistent benefits across different ET-1 levels and reduced serum ET-1 concentration.
Article
Biochemistry & Molecular Biology
Simone S. Riedel, Congcong Lu, Hongbo M. Xie, Kevin Nestler, Marit W. Vermunt, Alexandra Lenard, Laura Bennett, Nancy A. Speck, Ichiro Hanamura, Julie A. Lessard, Gerd A. Blobel, Benjamin A. Garcia, Kathrin M. Bernt
Summary: MN1 overexpression in AML results in destabilization of enhancer chromatin by interacting with the myeloid progenitor specific BAF complex, leading to impaired myeloid differentiation and leukemia. The study also shows that overexpression of a polyQ protein, without coding sequence mutation, can be sufficient to cause malignant transformation.
