Specific nitration of tyrosines 46 and 48 makes cytochromecassemble a non-functional apoptosome

Nitration of tyrosines 46 and 48 induces the specific degradation of cytochrome c upon change of the heme iron state to high-spin

(2011) Irene Díaz-Moreno et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Tyrosine phosphorylation turns alkaline transition into a biologically relevant process and makes human cytochrome c behave as an anti-apoptotic switch

(2011) José M. García-Heredia et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

The multiple functions of cytochrome c and their regulation in life and death decisions of the mammalian cell: From respiration to apoptosis

(2011) Maik Hüttemann et al.   MITOCHONDRION

Phosphomimetic Substitution of CytochromecTyrosine 48 Decreases Respiration and Binding to Cardiolipin and Abolishes Ability to Trigger Downstream Caspase Activation

(2010) Petr Pecina et al.   BIOCHEMISTRY

Nitration of tyrosine 74 prevents human cytochrome c to play a key role in apoptosis signaling by blocking caspase-9 activation

(2010) José M. García-Heredia et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Mechanisms of Peroxynitrite Interactions with Heme Proteins

(2010) Jia Su et al.   INORGANIC CHEMISTRY

Mammalian liver cytochrome c is tyrosine-48 phosphorylated in vivo, inhibiting mitochondrial respiration

(2008) Hong Yu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS