Journal
FEBS LETTERS
Volume 585, Issue 8, Pages 1243-1248Publisher
WILEY
DOI: 10.1016/j.febslet.2011.03.058
Keywords
Cdk5; Gsk-3 beta; Amyloid beta; Phosphorylation; Alzheimer's disease
Funding
- MSHE [N N401 014635]
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The aim of the present study was to analyse the alterations of Cyclin dependent kinase 5 (Cdk5) expression and phosphorylation in PC12 cells overexpressing Amyloid precursor protein (APP). Our results demonstrated enhanced cell death and increased levels of mRNA for the Cdk5 gene in APP-transfected cells. Significantly decreased phosphorylation of Cdk5 at Tyr15 was observed in APPsw cells, which is responsible for a reduction in Cdk5 activity. Cdk5-dependent phosphorylation of Glycogen synthase kinase-3 beta (Gsk-3 beta) at Ser9 was also decreased, which can lead to the increase of Gsk-3 beta activity and hyperphosphorylation of MAP tau. Our results demonstrate for the first time, a deregulation of Cdk5 phosphorylation in APP-transfected cells. (C) 2011 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
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