Article
Oncology
Zhipeng Li, Zeyu Zhu, Yanjun Wang, Ying Wang, Weibing Li, Zhigang Wang, Xinyuan Zhou, Yuhua Bao
Summary: Colon carcinoma is a common cancer with unsatisfactory treatment strategies, especially for advanced cases. Dysregulated miRNAs are believed to impact tumor development, with has-miR-15a-5p found to inhibit proliferation and migration of colon cancer cells by targeting the CCND1 gene. This study suggests that has-miR-15a-5p could serve as a potential molecular target for the diagnosis and treatment of colon cancer.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Immunology
Katharina Hutter, Thomas Rulicke, Tamas G. Szabo, Lill Andersen, Andreas Villunger, Sebastian Herzog
Summary: MicroRNAs (miRNAs) are small non-coding RNAs that play important roles in the development and function of immune cells. The miR-15 family has been shown to suppress tumors in chronic lymphocytic leukemia. However, its physiological functions are not well understood. This study reveals that the miR-15 family restricts the expansion of progenitor B cells by inhibiting cell cycle regulators and IL-7 receptor expression.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Hematology
Tomasz Sewastianik, Juerg R. Straubhaar, Jian-Jun Zhao, Mehmet K. Samur, Keith Adler, Helen E. Tanton, Vignesh Shanmugam, Omar Nadeem, Peter S. Dennis, Vinodh Pillai, Jianli Wang, Meng Jiang, Jianhong Lin, Ying Huang, Daniel Brooks, Mary Bouxsein, David M. Dorfman, Geraldine S. Pinkus, Davide F. Robbiani, Irene M. Ghobrial, Bogdan Budnik, Petr Jarolim, Nikhil C. Munshi, Kenneth C. Anderson, Ruben D. Carrasco
Summary: The deletion of miR-15a/16-1 cluster in murine GC B cells induces moderate but widespread molecular and functional changes, leading to the development of mature B-cell neoplasms resembling human extramedullary plasmacytoma and lymphoma. The low expression levels of miR-15a/16 in human primary EP, primarily associated with del(13q) loss, highlights the tumor-suppressor role of this cluster in plasma cell and B-cell malignancies.
Article
Oncology
Jiangfeng Du, Ji Li, Jianjun Tan, Yi Yan
Summary: This study investigated the effect of scutellarin on the proliferation of glioma cells and found that it works by regulating the expression of miR-15a.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2023)
Article
Medicine, Research & Experimental
Qingling Zheng, Jin Zhang, Ting Zhang, Yanxiang Liu, Xiuluan Du, Xin Dai, Donghua Gu
Summary: The study found that hsa_circ_0000520 and CDK2 were highly expressed in cervical cancer tissues, and hsa_circ_0000520 could competitively bind to miR-1296 to affect CDK2 expression, thereby inhibiting cell proliferation and promoting apoptosis.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Endocrinology & Metabolism
Nicola Murgia, Yuan Ma, Syeda Sadia Najam, Yu Liu, Joanna Przybys, Chenkai Guo, Witold Konopka, Ilya A. Vinnikov
Summary: In this study, the researchers demonstrate the protective effect of miR-15a-5p against obesity using an in vivo reductionist approach. They also identify Bace1 as a direct target of miR-15a-5p, a gene previously linked to energy metabolism imbalance. This research provides important insights into the non-coding RNA-mediated regulation of energy homeostasis and its potential contribution to the development of novel therapeutic approaches for metabolic diseases.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Emeline Bollaert, Melissa Claus, Virginie Vandewalle, Sandrine Lenglez, Ahmed Essaghir, Jean-Baptiste Demoulin, Violaine Havelange
Summary: The study found that miR-15a-5p induces chemoresistance in AML cells by inhibiting daunorubicin-induced autophagy, suggesting that this miRNA could be a promising therapeutic target for chemoresistant AML patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Vanessa M. Diaz Almanzar, Kunal Shah, Joseph F. LaComb, Aisharja Mojumdar, Hetvi R. Patel, Jacky Cheung, Meiyi Tang, Jingfang Ju, Agnieszka B. Bialkowska
Summary: Chronic pancreatitis is characterized by inflammation and fibrosis, which are worsened by activated pancreatic stellate cells (PSCs). Recent research shows that miR-15a, which targets YAP1 and BCL-2, is significantly downregulated in patients with chronic pancreatitis. We demonstrated that 5-FU-miR-15a can effectively inhibit PSC viability, proliferation, and migration, as well as reduce the invasion of pancreatic cancer cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Pan Jiang, Lianghao Mao, Xuan Lei, Chunshan Luo, Yiming Zhang, Xinyu Zhong, Zhenyu Yin, Xiaofeng Xu, Dapeng Li, Qiping Zheng
Summary: The present study demonstrated that miR-1297 inhibited proliferation and tumor growth in osteosarcoma by directly targeting CCND2.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Article
Oncology
Pan Jiang, Lianghao Mao, Xuan Lei, Chunshan Luo, Yiming Zhang, Xinyu Zhong, Zhenyu Yin, Xiaofeng Xu, Dapeng Li, Qiping Zheng
Summary: The study revealed that miR-1297 can inhibit proliferation and tumor growth in osteosarcoma by directly targeting CCND2. Overexpression of miR-1297 significantly suppressed CCND2 protein expression and resulted in similar phenotypic effects as CCND2 downregulation. Therefore, miR-1297 may represent a novel therapeutic target for osteosarcoma.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Article
Oncology
Thomas J. Kalantzakos, Travis B. Sullivan, Luke E. Sebel, David Canes, Eric J. Burks, Alireza Moinzadeh, Kimberly M. Rieger-Christ
Summary: The dysregulation of miR-15a-5p and -26a-5p cooperatively contribute to the proliferation of ccRCC through their regulation of OGT. These findings provide insight into the pathogenesis of aggressive early stage ccRCC and suggest potential therapeutic targets for future research.
Article
Biochemistry & Molecular Biology
Paulina Kober, Beata Joanna Mossakowska, Natalia Rusetska, Szymon Baluszek, Emilia Grecka, Ryszard Konopinski, Ewa Matyja, Artur Ozieblo, Tomasz Mandat, Mateusz Bujko
Summary: This study reveals the involvement of MIR193B gene hypermethylation in the pathogenesis of meningiomas, leading to downregulation of two miRNAs and subsequent inhibition of meningioma cell proliferation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Meghali Joshi, Syed Waseem Andrabi, Ranjeet Kumar Yadav, Satya Narayan Sankhwar, Gopal Gupta, Singh Rajender
Summary: Three miRNAs (hsa-miR-9-3p, hsa-miR-30b-5p, and hsa-miR-122-5p) have been found to have a strong linkage with infertility and high potential as sperm quality biomarkers.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2022)
Article
Oncology
Yiguan Qian, Yang Li, Luwei Xu, Ke Chen, Ning Liu, Xiaobing Yang, Qian Lv, Rongfei Li, Changcheng Zhou, Zheng Xu, Ruipeng Jia, Yu-Zheng Ge
Summary: In this study, a novel circRNA called circ-PRKCI was found to promote the proliferation of renal cell carcinoma (RCC) through the miR-545-3p/CCND1 signaling pathway. It was also discovered that tumor cell-derived exosomal circ-PRKCI could enhance the proliferation, migration, and invasion of RCC cells while inhibiting apoptosis. This study provides new insights into the molecular mechanisms of RCC progression.
Review
Cell Biology
Austin Bell-Hensley, Samarjit Das, Audrey McAlinden
Summary: MicroRNAs (miRNAs) are epigenetic regulators that can target and inhibit translation of multiple mRNAs within a given cell type. They are known to regulate various cellular processes including differentiation, proliferation, inflammation, and metabolism. This review focuses on the role of miR-181 family in regulating a range of activities in different cell types and tissues, and its potential therapeutic applications in treating human diseases and repair conditions.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)