Journal
FEBS LETTERS
Volume 584, Issue 18, Pages 3891-3895Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2010.08.010
Keywords
Simian virus 40; DJ-1; Transformation; p53
Funding
- Ministry of Education, Science, Culture and Sports
- National Institute of Biomedical Innovation (NIBIO) in Japan
- Nagai Foundation Tokyo
- Grants-in-Aid for Scientific Research [21390014] Funding Source: KAKEN
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Simian virus 40 (SV40) is a tumor virus and its early gene product large T-antigen (LT) is responsible for the transforming activity of SV40. Parkinson's disease causative gene DJ-1 is also a ras-dependent oncogene, but the mechanism of its oncogene function is still not known. In this study, we found that there were no transformed foci when fibroblasts from DJ-1-knockout mice were transfected with LT. We also found that DJ-1 directly bound to LT and that the expression level of c-Myc in transformed cells was parallel to that of DJ-1. These findings indicate that DJ-1 is essential for SV40 transformation. Structured summary: MINT-7988969: DJ-1 (uniprotkb:Q99497) binds (MI:0407) to LT SV40 (uniprotkb:P03070) by pull down (MI:0096) MINT-7988948: LT SV40 (uniprotkb:P03070) physically interacts (MI:0914) with DJ-1 (uniprotkb:Q99LX0) and p53 (uniprotkb:P02340) by anti bait coimmunoprecipitation (MI:0006) (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
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