Crystal structure of the HIV-1 integrase core domain in complex with sucrose reveals details of an allosteric inhibitory binding site

Non-nucleoside reverse transcriptase inhibitors (NNRTIs), their discovery, development, and use in the treatment of HIV-1 infection: A review of the last 20 years (1989–2009)

(2009) Marie-Pierre de Béthune   ANTIVIRAL RESEARCH

Potent Inhibitors of HIV-1 Integrase Display a Two-Step, Slow-Binding Inhibition Mechanism Which Is Absent in a Drug-Resistant T66I/M154I Mutant

(2009) Edward P. Garvey et al.   BIOCHEMISTRY

Structural basis for HIV-1 DNA integration in the human genome, role of the LEDGF/P75 cofactor

(2009) Fabrice Michel et al.   EMBO JOURNAL

Treatment of HIV infection with raltegravir

(2009) Lisa M Chirch et al.   EXPERT OPINION ON PHARMACOTHERAPY

Raltegravir, Etravirine, and Ritonavir-Boosted Darunavir: A Safe and Successful Rescue Regimen for Multidrug-Resistant HIV-1 Infection

(2009) Arkaitz Imaz et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Identifying and Characterizing a Functional HIV-1 Reverse Transcriptase-binding Site on Integrase

(2009) Thomas A. Wilkinson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Integrase Interacts with Nucleoporin NUP153 To Mediate the Nuclear Import of Human Immunodeficiency Virus Type 1

(2009) C. L. Woodward et al.   JOURNAL OF VIROLOGY

An Allosteric Mechanism for Inhibiting HIV-1 Integrase with a Small Molecule

(2009) J. J. Kessl et al.   MOLECULAR PHARMACOLOGY

Inhibition of HIV-1 integrase nuclear import and replication by a peptide bearing integrase putative nuclear localization signal

(2009) Aviad Levin et al.   Retrovirology

A Novel Co-Crystal Structure Affords the Design of Gain-of-Function Lentiviral Integrase Mutants in the Presence of Modified PSIP1/LEDGF/p75

(2009) Stephen Hare et al.   PLoS Pathogens

Structural Basis for Functional Tetramerization of Lentiviral Integrase

(2009) Stephen Hare et al.   PLoS Pathogens

Symmetrical 1-pyrrolidineacetamide showing anti-HIV activity through a new binding site on HIV-1 integrase1

(2008) Li DU et al.   ACTA PHARMACOLOGICA SINICA

Comparison of Raltegravir and Elvitegravir on HIV-1 Integrase Catalytic Reactions and on a Series of Drug-Resistant Integrase Mutants†

(2008) Jessica Marinello et al.   BIOCHEMISTRY

Integrase, LEDGF/p75 and HIV replication

(2008) E. M. Poeschla   CELLULAR AND MOLECULAR LIFE SCIENCES

Discovery of Raltegravir, a Potent, Selective Orally Bioavailable HIV-Integrase Inhibitor for the Treatment of HIV-AIDS Infection

(2008) Vincenzo Summa et al.   JOURNAL OF MEDICINAL CHEMISTRY

Identification and Characterization of PWWP Domain Residues Critical for LEDGF/p75 Chromatin Binding and Human Immunodeficiency Virus Type 1 Infectivity

(2008) M.-C. Shun et al.   JOURNAL OF VIROLOGY

In search of small molecules blocking interactions between HIV proteins and intracellularcofactors

(2008) Katrien Busschots et al.   Molecular BioSystems

Identification of Host Proteins Required for HIV Infection Through a Functional Genomic Screen

(2008) Abraham L. Brass et al.   SCIENCE

Mapping of immunogenic and protein-interacting regions at the surface of the seven-bladed beta-propeller domain of the HIV-1 cellular interactor EED

(2008) Dina Rakotobe et al.   Virology Journal

The Lentiviral Integrase Binding Protein LEDGF/p75 and HIV-1 Replication

(2008) Alan Engelman et al.   PLoS Pathogens