Molecular mechanisms of tumor suppression by LKB1

Impaired Gastric Gland Differentiation in Peutz-Jeghers Syndrome

(2010) Lina Udd et al.   AMERICAN JOURNAL OF PATHOLOGY

Integrative Genomic and Proteomic Analyses Identify Targets for Lkb1-Deficient Metastatic Lung Tumors

(2010) Julian Carretero et al.   CANCER CELL

SIK2 Is a Centrosome Kinase Required for Bipolar Mitotic Spindle Formation that Provides a Potential Target for Therapy in Ovarian Cancer

(2010) Ahmed Ashour Ahmed et al.   CANCER CELL

Fyn-Dependent Regulation of Energy Expenditure and Body Weight Is Mediated by Tyrosine Phosphorylation of LKB1

(2010) Eijiro Yamada et al.   Cell Metabolism

Polarity protein alterations in carcinoma: a focus on emerging roles for polarity regulators

(2010) Ling Huang et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Differential requirements for STRAD in LKB1-dependent functions in C. elegans

(2010) P. Narbonne et al.   DEVELOPMENT

Lkb1 inactivation is sufficient to drive endometrial cancers that are aggressive yet highly responsive to mTOR inhibitor monotherapy

(2010) C. M. Contreras et al.   Disease Models & Mechanisms

LKB1 Haploinsufficiency Cooperates With Kras to Promote Pancreatic Cancer Through Suppression of p21-Dependent Growth Arrest

(2010) Jennifer P. Morton et al.   GASTROENTEROLOGY

Lung Adenocarcinoma From East Asian Never-Smokers Is a Disease Largely Defined by Targetable Oncogenic Mutant Kinases

(2010) Yihua Sun et al.   JOURNAL OF CLINICAL ONCOLOGY

Spectrum of LKB1, EGFR, and KRAS Mutations in Chinese Lung Adenocarcinomas

(2010) Bin Gao et al.   Journal of Thoracic Oncology

Involvement of LKB1 in epithelial–mesenchymal transition (EMT) of human lung cancer cells

(2010) Badal C. Roy et al.   LUNG CANCER

AID-Induced Genotoxic Stress Promotes B Cell Differentiation in the Germinal Center via ATM and LKB1 Signaling

(2010) Mara H. Sherman et al.   MOLECULAR CELL

Diverse somatic mutation patterns and pathway alterations in human cancers

(2010) Zhengyan Kan et al.   NATURE

AMPK controls the speed of microtubule polymerization and directional cell migration through CLIP-170 phosphorylation

(2010) Atsushi Nakano et al.   NATURE CELL BIOLOGY

Primary cilia regulate mTORC1 activity and cell size through Lkb1

(2010) Christopher Boehlke et al.   NATURE CELL BIOLOGY

 -Subunit myristoylation is the gatekeeper for initiating metabolic stress sensing by AMP-activated protein kinase (AMPK)

(2010) J. S. Oakhill et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

LKB1 inhibits lung cancer progression through lysyl oxidase and extracellular matrix remodeling

(2010) Y. Gao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Signaling Kinase AMPK Activates Stress-Promoted Transcription via Histone H2B Phosphorylation

(2010) D. Bungard et al.   SCIENCE

The cytoskeleton and cancer

(2009) Alan Hall   CANCER AND METASTASIS REVIEWS

LKB1 Regulates Pancreatic β Cell Size, Polarity, and Function

(2009) Zvi Granot et al.   Cell Metabolism

Loss of Lkb1 in Adult β Cells Increases β Cell Mass and Enhances Glucose Tolerance in Mice

(2009) Accalia Fu et al.   Cell Metabolism

Regulation of ploidy and senescence by the AMPK-related kinase NUAK1

(2009) Nicolas Humbert et al.   EMBO JOURNAL

AMPK: Lessons from transgenic and knockout animals

(2009) Benoit Viollet   Frontiers in Bioscience-Landmark

Oral rapamycin reduces tumour burden and vascularization inLkb1+/−mice

(2009) James Robinson et al.   JOURNAL OF PATHOLOGY

Conditional deletion of theLkb1gene in the mouse mammary gland induces tumour formation

(2009) Afshan McCarthy et al.   JOURNAL OF PATHOLOGY

Oncogenic B-RAF Negatively Regulates the Tumor Suppressor LKB1 to Promote Melanoma Cell Proliferation

(2009) Bin Zheng et al.   MOLECULAR CELL

SADB phosphorylation of γ-tubulin regulates centrosome duplication

(2009) María Alvarado-Kristensson et al.   NATURE CELL BIOLOGY

Lkb1 Deficiency Alters Goblet and Paneth Cell Differentiation in the Small Intestine

(2009) Boris Y. Shorning et al.   PLoS One

Somatic LKB1 Mutations Promote Cervical Cancer Progression

(2009) Shana N. Wingo et al.   PLoS One

mTOR and HIF-1 -mediated tumor metabolism in an LKB1 mouse model of Peutz-Jeghers syndrome

(2009) D. B. Shackelford et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

LKB1 regulates polarity remodeling and adherens junction formation in the Drosophila eye

(2009) N. Amin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of the LKB1-STRAD-MO25 Complex Reveals an Allosteric Mechanism of Kinase Activation

(2009) E. Zeqiraj et al.   SCIENCE

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Important role of the LKB1–AMPK pathway in suppressing tumorigenesis in PTEN-deficient mice

(2008) Xu Huang et al.   BIOCHEMICAL JOURNAL

Control of AMPK-related kinases by USP9X and atypical Lys29/Lys33-linked polyubiquitin chains

(2008) Abdallah K. Al-Hakim et al.   BIOCHEMICAL JOURNAL

Mutations in the LKB1 tumour suppressor are frequently detected in tumours from Caucasian but not Asian lung cancer patients

(2008) J P Koivunen et al.   BRITISH JOURNAL OF CANCER

Loss of Lkb1 Provokes Highly Invasive Endometrial Adenocarcinomas

(2008) C. M. Contreras et al.   CANCER RESEARCH

Lkb1 Deficiency Causes Prostate Neoplasia in the Mouse

(2008) H. B. Pearson et al.   CANCER RESEARCH

LKB1 Deficiency Sensitizes Mice to Carcinogen-Induced Tumorigenesis

(2008) S. Gurumurthy et al.   CANCER RESEARCH

Regulation of LKB1/STRAD Localization and Function by E-Cadherin

(2008) Michael Sebbagh et al.   CURRENT BIOLOGY

LKB1 in endothelial cells is required for angiogenesis and TGF -mediated vascular smooth muscle cell recruitment

(2008) A. Londesborough et al.   DEVELOPMENT

Osteogenic tumours in Lkb1-deficient mice

(2008) James Robinson et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Myosin light chains are not a physiological substrate of AMPK in the control of cell structure changes

(2008) Laurent Bultot et al.   FEBS LETTERS

TheCaenorhabditis elegansAMP-activated Protein Kinase AAK-2 Is Phosphorylated by LKB1 and Is Required for Resistance to Oxidative Stress and for Normal Motility and Foraging Behavior

(2008) Hyojin Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TGFβ induces SIK to negatively regulate type I receptor kinase signaling

(2008) Marcin Kowanetz et al.   JOURNAL OF CELL BIOLOGY

Lkb1 is required for TGF -mediated myofibroblast differentiation

(2008) K. Vaahtomeri et al.   JOURNAL OF CELL SCIENCE

Pancreatic Lkb1 Deletion Leads to Acinar Polarity Defects and Cystic Neoplasms

(2008) A. F. Hezel et al.   MOLECULAR AND CELLULAR BIOLOGY

Somatic mutations affect key pathways in lung adenocarcinoma

(2008) Li Ding et al.   NATURE

LKB1 signaling in mesenchymal cells required for suppression of gastrointestinal polyposis

(2008) Pekka Katajisto et al.   NATURE GENETICS

Integrated network analysis platform for protein-protein interactions

(2008) Jianmin Wu et al.   NATURE METHODS