Journal
FEBS LETTERS
Volume 585, Issue 1, Pages 261-265Publisher
WILEY
DOI: 10.1016/j.febslet.2010.11.056
Keywords
Coxsackievirus B3; Tripeptidyl peptidase II; Ubiquitin/proteasome system; Virus replication
Funding
- Canadian Institutes of Health Research (CIHR)
- Heart and Stroke Foundation of British Columbia and Yukon
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The ubiquitin-proteasome system is known to be utilized by coxsackievirus to facilitate its propagation within the host cells. The present study explores the role of tripeptidyl peptidase II (TPPII), a serine peptidase contributing to protein turnover by acting downstream of the proteasome, in regulating coxsackievirus infection. Inhibition of TPPII does not affect virus replication in cells with functional proteasome. However, when the proteasome is impaired, TPPII appears to serve as an alternative to maintain low levels of virus infection. Our results suggest an important function of TPPII in the maintenance of viral growth and may have implications for anti-viral therapy. (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
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