☆ 4.5 Article

Evodiamine inhibits adipogenesis via the EGFR-PKCα-ERK signaling pathway

FEBS LETTERS (2009)

Journal

FEBS LETTERS

Volume 583, Issue 22, Pages 3655-3659

Publisher

WILEY

DOI: 10.1016/j.febslet.2009.10.046

Keywords

Evodiamine; Adipogenesis; Epidermal growth factor receptor; Protein kinase C alpha; Extracellularly regulated kinase

Categories

Biochemistry & Molecular Biology Biophysics Cell Biology

Funding

MEXT

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Abstract

The molecular mechanism of the anti-adipogenic effect of evodiamine (which has several capsaicin-like pharmacological actions) was investigated. The evodiamine effect was not blocked by the specific TRPV1 antagonist capsazepine in 3T3-L1 preadipocytes, whereas its effect was greatly curtailed by inhibitors of protein kinase C (PKC) and epidermal growth factor receptor (EGFR). Signal analyses showed that evodiamine stimulated the phosphorylation of EGFR, PKC alpha, and ERK, all of which were reduced by an EGFR inhibitor. Silencing experiments of EGFR mRNA supported the involvement of these signaling molecules in the inhibitory effect of evodiamine. An unidentified mechanism whereby evodiamine inhibits adipogenesis via the EGFR-PKC alpha-ERK signaling pathway was revealed. (C) 2009 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.

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