Article
Endocrinology & Metabolism
Benjamin Brustolin, Nina Touly, Marine Maillefer, Lola Parisot, Elisa Di Pillo, Marc Derive, Sebastien Gibot
Summary: This study demonstrates that TREM-1 plays a significant role in obesity and its associated complications. In the mouse model of high-fat diet-induced obesity, suppressing TREM-1 reduces weight gain, insulin resistance, and inflammation in white adipose tissue and liver. Therefore, TREM-1 could be a potential therapeutic target for obesity.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Pharmacology & Pharmacy
Syota Kagawa, Katsuya Tanabe, Makoto Hiromura, Kakuyou Ogawa, Takayuki Koga, Takahiro Maeda, Kikuko Amo-Shiinoki, Hiroyuki Ochi, Yui Ichiki, Shogo Fukuyama, Saori Suzuki, Natsuki Suizu, Takaaki Ohmine, Sakurako Hamachi, Hiroshi Tsuneki, Shigeru Okuya, Toshiyasu Sasaoka, Yukio Tanizawa, Fumihiro Nagashima
Summary: Hachimijiogan (HJG) was originally used to alleviate symptoms associated with low ambient temperatures, but its metabolic effects remained unclear. This study found that HJG modulates adipocyte function, reduces adipocyte size, and improves insulin sensitivity, potentially providing therapeutic benefits against obesity and insulin resistance.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Shih-Yi Lin, Ya-Yu Wang, Pin-Ho Pan, Jiaan-Der Wang, Ching-Ping Yang, Wen-Ying Chen, Yu-Hsiang Kuan, Su-Lan Liao, Yu-Li Lo, Yih-Hsin Chang, Chun-Jung Chen
Summary: This study investigated the effects of DHA on obesity-related inflammation and adipose tissue browning in obese mice. The results showed that DHA improved obesity phenotypes, including insulin resistance, inflammation, and macrophage polarization in the liver and adipose tissues. Furthermore, DHA alleviated dysregulated adipokines and impaired thermogenic and browning molecules, along with ER stress and mitochondrial dysfunction.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Article
Nutrition & Dietetics
Beegum Noorjahan Shijina, Achuthan Radhika, Sainulabdeen Sherin, Prabath Gopalakrishnan Biju
Summary: The indole alkaloid vindoline from Catharanthus roseus was found to have significant improvements in insulin resistance, oxidative stress, and inflammatory responses. It enhanced glucose metabolism and increased the expression of insulin receptors, alleviating symptoms of insulin resistance.
Article
Endocrinology & Metabolism
Hao Xie, Yu-han Wang, Xin Liu, Jia Gao, Chunliang Yang, Teng Huang, Lu Zhang, Xi Luo, Zhichao Gao, Ting Wang, Tong Yan, Yanjun Liu, Ping Yang, Qilin Yu, Shiwei Liu, Yi Wang, Fei Xiong, Shu Zhang, Qing Zhou, Cong-Yi Wang
Summary: This study revealed that the deficiency of Ubc9 in adipocytes can protect mice from obesity, insulin resistance, and hepatosteatosis induced by a high-fat diet. The lack of Ubc9 reduces endoplasmic reticulum stress and inflammatory response. Mechanistically, Ubc9 deficiency enhances the degradation of ERp44 and promotes Ero1 alpha secretion to alleviate endoplasmic reticulum stress.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2023)
Article
Biochemistry & Molecular Biology
Julian Roos, Meike Dahlhaus, Jan-Bernd Funcke, Monika Kustermann, Gudrun Strauss, Daniel Halbgebauer, Elena Boldrin, Karlheinz Holzmann, Peter Moeller, Bernadette M. Trojanowski, Bernd Baumann, Klaus-Michael Debatin, Martin Wabitsch, Pamela Fischer-Posovszky
Summary: The study revealed that miR-146a regulates adipose tissue inflammation by suppressing the NPR3 gene, thereby impacting the development of obesity and insulin resistance.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Multidisciplinary Sciences
Bingyang Dai, Jiankun Xu, Xu Li, Le Huang, Chelsea Hopkins, Honglian Wang, Hao Yao, Jie Mi, Lizhen Zheng, Jiali Wang, Wenxue Tong, Dick Ho-Kiu Chow, Ye Li, Xuan He, Peijie Hu, Ziyi Chen, Haiyue Zu, Yixuan Li, Yao Yao, Qing Jiang, Ling Qin
Summary: This study found that osteopontin secreted by epididymal white adipose tissue activates osteoclasts and promotes bone matrix degradation. It also modulates macrophages to engulf lipid droplets released from adipocytes. Surgical removal of adipose tissue or injection of antibodies can alleviate high-fat diet-induced bone loss.
NATURE COMMUNICATIONS
(2022)
Article
Cell Biology
R. Guzman-Ruiz, C. Tercero-Alcazar, J. Lopez-Alcala, J. Sanchez-Ceinos, M. M. Malagon, A. Gordon
Summary: The discovery of adipose tissue as a major source of signaling molecules led to the identification of metabolic organs as endocrine organs. Adipokines produced by adipocytes play a role in intercellular communication and systemic responses, with novel adipokines like HMGB1 showing potential implications in obesity and related conditions. HMGB1, originally known for its inflammatory function, has been found to also play a role in tissue remodeling and fibrosis, suggesting it as a potential target in obesity treatment.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2021)
Article
Multidisciplinary Sciences
Dong-Keon Lee, Taesam Kim, Junyoung Byeon, Minsik Park, Suji Kim, Joohwan Kim, Seunghwan Choi, Gihwan Lee, Chanin Park, Keun Woo Lee, Yong Jung Kwon, Jeong-Hyung Lee, Young-Guen Kwon, Young-Myeong Kim
Summary: The REDD1-NF-kappa B axis plays a crucial role in metabolic inflammation and dysregulation, with Redd1 deficiency inhibiting diet-induced obesity, inflammation, insulin resistance, and hepatic steatosis.
NATURE COMMUNICATIONS
(2022)
Article
Endocrinology & Metabolism
Wen Dai, Mayank Choubey, Sonal Patel, Harold A. Singer, Lale Ozcan
Summary: The study found that increased CAMK2 activity in obese adipose tissue, removal of CAMK2 in adipocytes in adult mice improved glucose intolerance and insulin resistance without affecting body weight. Mechanistically, activation of CAMK2 disrupted adipocyte insulin signaling and decreased the amount of insulin receptor.
MOLECULAR METABOLISM
(2021)
Review
Cell Biology
Regine Asen Jersin, Laura Roxana Jonassen, Simon Nitter Dankel
Summary: SLC7A10 is highly expressed in adipocytes and is inversely correlated with insulin resistance, adipocyte size, and components of the metabolic syndrome. It has been found to increase mitochondrial activity and reduce reactive oxygen species in white adipocytes.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Medicine, General & Internal
Jelena Nesic, Biljana Ljujic, Vesna Rosic, Aleksandar Djukic, Milenko Rosic, Ivica Petrovic, Nenad Zornic, Ivan P. Jovanovic, Sara Petrovic, Svetlana Djukic
Summary: Adiponectin and interleukin-33 are associated in patients with metabolic syndrome, with adiponectin potentially serving as an early marker and interleukin-33 being a potential predictor of inflammatory status in the early stage.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Jocelyne Magre, Xavier Prieur
Summary: Obesity is associated with increasing global cardiometabolic diseases, with dysfunctional adipocytes playing a central role. Rare syndromes like Berardinelli-Seip congenital lipodystrophy (BSCL) are considered primary adipocyte dysfunction diseases. Mutations in the BSCL2 gene cause BSCL, with seipin deficiency leading to severe lipodystrophy and cardiometabolic complications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Xi Pu, Deyu Chen
Summary: Obesity is a global epidemic and closely related to the occurrence and development of various tumors, adipokines secreted by adipocytes and insulin/IGF play important roles in tumors.
FRONTIERS IN ONCOLOGY
(2021)
Article
Cell Biology
Hahn Nahmgoong, Yong Geun Jeon, Eun Seo Park, Yoon Ha Choi, Sang Mun Han, Jeu Park, Yul Ji, Jee Hyung Sohn, Ji Seul Han, Ye Young Kim, Injae Hwang, Yun Kyung Lee, Jin Young Huh, Sung Sik Choe, Tae Jung Oh, Sung Hee Choi, Jong Kyoung Kim, Jae Bum Kim
Summary: This study characterized adipose stem cells (ASCs) in two different types of white adipose tissues (EAT and IAT) and investigated the effects of intrinsic and tissue micro-environmental factors on ASC features. The results showed that ASC subpopulations in EAT and IAT exhibited different molecular features and adipogenic potential. Furthermore, ASCs in these two depots responded differently to obesogenic stimuli, influencing the characteristics of the adipose tissues.
Article
Geosciences, Multidisciplinary
M. J. Stumvoll, E. M. Schmaltz, R. Kanta, H. Roth, B. Grall, J. Luhn, A. Flores-Orozco, T. Glade
Summary: This study investigates a complex and slow-moving landslide-earth flow system in the Flysch Zone of Lower Austria. By conducting long-term measurements on surface and subsurface parameters, the study examines the interrelations between hydrometeorological input data, subsurface hydrology, subsurface dynamics, and surface dynamics. The results show overall marginal dynamics, but reveal several relationships between the present state and the known former dynamics.
Article
Biochemistry & Molecular Biology
Chang Sun, Franz Forster, Beate Gutsmann, Yusef Moulla, Christine Stroh, Arne Dietrich, Michael R. Schoen, Daniel Gaertner, Tobias Lohmann, Miriam Dressler, Michael Stumvoll, Matthias Blueher, Peter Kovacs, Jana Breitfeld, Esther Guiu-Jurado
Summary: The GRB14/COBLL1 locus is associated with body fat distribution and metabolic diseases, particularly involving lipid metabolism and glucose homeostasis, likely mediated by AT GRB14 transcript levels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Ireen Klemp, Anne Hoffmann, Luise Mueller, Tobias Hagemann, Kathrin Horn, Kerstin Rohde-Zimmermann, Anke Toenjes, Joachim Thiery, Markus Loeffler, Ralph Burkhardt, Yvonne Boettcher, Michael Stumvoll, Matthias Blueher, Knut Krohn, Markus Scholz, Ronny Baber, Paul W. Franks, Peter Kovacs, Maria Keller
Summary: The study found that lifestyle factors have an impact on blood DNA methylation, which can help distinguish individuals with a healthy or unhealthy lifestyle, and may even mask methylation differences caused by obesity.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Anja Saalbach, Ulf Anderegg, Ralph Wendt, Joachim Beige, Anette Bachmann, Nora Kloeting, Matthias Blueher, Ming-Zhi Zhang, Raymond C. Harris, Michael Stumvoll, Anke Toenjes, Thomas Ebert
Summary: Kidney fibrosis, a major factor in chronic kidney disease (CKD), leads to irreversible organ function loss. This study investigated the association of the soluble form of Thymocyte differentiation antigen-1 (sThy-1) with clinical parameters in CKD patients receiving hemodialysis. The study also examined Thy-1 tissue expression in a mouse model of diabetic CKD. The results showed that sThy-1 levels increased with worsening renal function, regardless of the presence of diabetes. Serum creatinine was found to be a major predictor of sThy-1 levels. Additionally, sThy-1 was found to be an independent predictor of markers of renal function. The study suggests that Thy-1 may have a role in controlling kidney fibrosis and could potentially be used as a renal antifibrotic factor.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Genetics & Heredity
Janine Molder, Esther Guiu-Jurado, Yusef Moulla, Christine Stroh, Arne Dietrich, Michael R. Schoen, Daniel Gaertner, Tobias Lohmann, Miriam Dressler, Michael Stumvoll, Peter Kovacs, Matthias Blueher, Nora Kloeting
Summary: This study aimed to investigate the influence of SNP rs10487505 on leptin mRNA expression and obesity-related parameters. The researchers found that rs10487505 is associated with lower leptin levels in women and a lower mean BMI in women carrying the C allele. However, no association was found between rs10487505 and leptin mRNA expression in adipose tissue.
Article
Endocrinology & Metabolism
Noa Ofir, Yuval Mizrakli, Yariv Greenshpan, Yftach Gepner, Omri Sharabi, Gal Tsaban, Hila Zelicha, Anat Yaskolka Meir, Uta Ceglarek, Michael Stumvoll, Matthias Blueher, Yoash Chassidim, Assaf Rudich, Anat Reiner-Benaim, Iris Shai, Ilan Shelef, Roi Gazit
Summary: In this study, the researchers found that long-term weight loss can temporarily reduce bone marrow adipose tissue (BMAT) in adults, with more prominent effects in younger adults. The storage and dynamics of BMAT are largely independent of other fat depots or cardio-metabolic risk markers, highlighting its unique functions.
Review
Medicine, General & Internal
Lara Heuft, Jenny Voigt, Lars Selig, Michael Stumvoll, Haiko Schloegl, Thorsten Kaiser
Summary: This study investigates the role of clinical decision support systems (CDSS) in the diagnosis of refeeding syndrome (RFS) and highlights the importance of identifying high-risk patients. The literature review reveals that malnourished patients with RFS have higher mortality rates and an increased risk of ICU admission compared to those without RFS. The use of CDSS significantly improves the detection and diagnosis of RFS.
DEUTSCHES ARZTEBLATT INTERNATIONAL
(2023)
Article
Health Care Sciences & Services
Maximiliane Chiara Hammel, Robert Stein, Juergen Kratzsch, Mandy Vogel, Alexander J. Eckert, Rima Destya Triatin, Marco Colombo, Christof Meigen, Ronny Baber, Juraj Stanik, Ulrike Spielau, Anette Stoltze, Kerstin Wirkner, Anke Toenjes, Harold Snieder, Reinhard W. Holl, Michael Stumvoll, Matthias Blueher, Wieland Kiess, Antje Koerner
Summary: The study aimed to establish reference ranges for fasting insulin indices across all age ranges and evaluate their clinical application in predicting glycemic deterioration in children. The results showed that insulin resistance in children with obesity doubled the risk for future glycemic deterioration, and insulin-based indices were better predictors of dysglycemia than fasting glucose alone.
LANCET REGIONAL HEALTH-EUROPE
(2023)
Article
Medicine, General & Internal
Anat Yaskolka Meir, Maria Keller, Anne Hoffmann, Ehud Rinott, Gal Tsaban, Alon Kaplan, Hila Zelicha, Tobias Hagemann, Uta Ceglarek, Berend Isermann, Ilan Shelef, Matthias Blueher, Michael Stumvoll, Jun Li, Sven-Bastian Haange, Beatrice Engelmann, Ulrike Rolle-Kampczyk, Martin von Bergen, Frank B. Hu, Meir J. Stampfer, Peter Kovacs, Liming Liang, Iris Shai
Summary: This study found that Mediterranean and green-MED diets with increased polyphenols intake are inversely associated with biological aging. To the best of our knowledge, this is the first clinical trial to indicate a potential link between polyphenol intake, urine polyphenols, and biological aging.
Article
Gastroenterology & Hepatology
Evelyn Medawar, Frauke Beyer, Ronja Thieleking, Sven-Bastiaan Haange, Ulrike Rolle-Kampczyk, Madlen Reinicke, Rima Chakaroun, Martin von Bergen, Michael Stumvoll, Arno Villringer, A. Veronica Witte
Summary: This study investigated the effects of high-dosed prebiotic fiber on reward-related food decision-making in overweight young adults. The results showed that prebiotic intake decreased brain activation towards high-caloric food stimuli and caused shifts in gut microbiota.
Article
Endocrinology & Metabolism
Jana Breitfeld, Katrin Horn, Diana Le Duc, Akhil Velluva, Carola Marzi, Harald Grallert, Nele Friedrich, Maik Pietzner, Uwe Voelker, Henry Voelzke, Emma Ahlqvist, Dina Mansour Aly, Tiinamaija Tuomi, Ronny Baber, Juergen Kratzsch, Joachim Thiery, Berend Isermann, Markus Loeffler, Nora Kloeting, Matthias Blueher, Michael Stumvoll, John T. Heiker, Anke Toenjes, Markus Scholz, Peter Kovacs
Summary: This study found a correlation between genetic variants of the Vaspin gene and serum Vaspin levels, and further revealed the causal role of Vaspin in lipid metabolism.
Meeting Abstract
Ophthalmology
Yan Luo, Franziska G. Rauscher, Tobias Elze, Yu Tian, Min Shi, Saber Kazeminasab Hashemabad, Mohammad Eslami, Kerstin Wirkner, Thomas Peschel, Michael Stumvoll, Berend Isermann, Matthias Blueher, Markus Loeffler, Toralf Kirsten, Thomas Ebert, Mengyu Wang
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2023)
Article
Endocrinology & Metabolism
Diana Branco Vieira, Jochen Antel, Triinu Peters, Konstanze Miehle, Michael Stumvoll, Johannes Hebebrand, Haiko Schloegl
Summary: The study suggests that metreleptin may have an antidepressant effect in patients with lipodystrophy. The treatment resulted in a rapid reduction in depression scores within one week and this improvement persisted after three months of dosing.
Meeting Abstract
Endocrinology & Metabolism
H. Schloegl, A. Villringer, K. Miehle, M. Stumvoll, K. Mueller
Article
Peripheral Vascular Disease
Cornelia Then, Chaterina Sujana, Christian Herder, Holger Then, Margit Heier, Christa Meisinger, Annette Peters, Wolfgang Koenig, Wolfgang Rathmann, Haifa Maalmi, Katrin Ritzel, Michael Roden, Michael Stumvoll, Barbara Thorand, Jochen Seissler
Summary: This study found that CT-proET-1 is associated with cardiovascular disease and mortality, but not with cardiovascular events. CT-proET-1 also showed associations with subclinical inflammation and adipokines. These results emphasize the complex actions and/or indicator functions of CT-proET-1.
VASCULAR HEALTH AND RISK MANAGEMENT
(2022)
