Journal
FEBS LETTERS
Volume 583, Issue 8, Pages 1226-1230Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2009.03.017
Keywords
Glutamate; Lipid raft; Hippocampus; Rat; Neuron
Funding
- National Institute on Deafness and Other Communication Disorders (NIDCD)
- National Institute of General Medical Sciences (NIGMS)
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N-Methyl-D-aspartate receptors (NMDARs) mediate excitatory synaptic transmission in the brain. Here we demonstrate interactions between the NR2A and NR2B subunits of NMDARs with flotillin-1 (flot-1), a lipid raft-associated protein. When mapped, analogous regions in the far distal C-termini of NR2A and NR2B mediate binding to flot-1, and the prohibitin homology domain of flot-1 contains binding sites for NR2A and NR2B. Although NR2B can also directly bind to flot-2 via a separate region of its distal C-terminus, NMDARs were significantly more colocalized with flot-1 than flot-2 in cultured hippocampal neurons. Overall, this study defines a novel interaction between NMDARs and flotillins.
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