☆ 4.5 Article

IFNγ enhances IL-23 production during Francisella infection of human monocytes

FEBS LETTERS (2008)

Journal

FEBS LETTERS

Volume 582, Issue 7, Pages 1044-1048

Publisher

WILEY

DOI: 10.1016/j.febslet.2008.02.058

Keywords

host response; IL-23; monocytes; Francisella

Categories

Biochemistry & Molecular Biology Biophysics Cell Biology

Funding

NCI NIH HHS [P01 CA095426-060002, T32 CA090223, P01 CA095426, T32CA090223, T32 CA090223-05] Funding Source: Medline
NIAID NIH HHS [U54 AI057153, R01 AI059406, R01 AI059406-03, 1-U54-AI-057153, U54 AI057153-05] Funding Source: Medline

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Abstract

We previously demonstrated that monocytes produce IL-23 during Francisella infection, and that IL-23 induces IFN gamma from NK cells. Here, we demonstrate that IFN gamma-priming of monocytes enhances IL-23 production during Francisella infection. This effect was seen on the IL12/23 p40 subunit. Induction of IL-12/23 p40 is reported to be enhanced by IRF-1 and IRF-8. Consistently, microarray analysis of IFN gamma-treated monocytes revealed a significant induction of the IRFs. Interestingly, IFN gamma-primed monocytes produced IL-12 p70, a more potent inducer of IFN gamma than IL-23. We propose that there exists an amplification loop between monocyte IL-23 and NK/T cell IFN gamma that leads to IL-12 p70 production. (C) 2008 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

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